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Targeted electrical stimulation of the brain perturbs neural networks and modulates their rhythmic activity both at the site of stimulation and at remote brain regions. Understanding, or even predicting, this neuromodulatory effect is…

Neurons and Cognition · Quantitative Biology 2021-06-29 Christoforos Papasavvas , Peter Neal Taylor , Yujiang Wang

Cognitive neuroscience explores the mechanisms of cognition by studying its structural and functional brain correlates. Here, we report the first systematic review that assesses how information from structural and functional neuroimaging…

Neurons and Cognition · Quantitative Biology 2022-02-07 Marta Czime Litwińczuk , Nelson Trujillo-Barreto , Nils Muhlert , Lauren Cloutman , Anna Woollams

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

Understanding the intricate architecture of brain networks and its connection to brain function is essential for deciphering the underlying principles of cognition and disease. While traditional graph-theoretical measures have been widely…

Chaotic Dynamics · Physics 2025-11-13 Anca Radulescu , Eva Kaslik , Alexandru Fikl , Johan Nakuci , Sarah Muldoon , Michael Anderson

Functional connectivity (FC) between brain regions tracks symptom severity in many neuropsychiatric disorders. Transcranial magnetic stimulation (TMS) directly alters regional activity and indirectly alters FC. Predicting how FC will change…

Neurons and Cognition · Quantitative Biology 2022-08-25 Andrew C. Murphy , Romain Duprat , Theodore D. Satterthwaite , Desmond J. Oathes , Dani S. Bassett

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Brain connectomics is a developing field in neurosciences which strives to understand cognitive processes and psychiatric diseases through the analysis of interactions between brain regions. However, in the high-dimensional, low-sample, and…

Applications · Statistics 2019-11-15 Claire Donnat , Leonardo Tozzi , Susan Holmes

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

Machine Learning · Computer Science 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

Neurons and Cognition · Quantitative Biology 2013-04-16 Gaël Varoquaux , R. C. Craddock

Functional magnetic resonance imaging (fMRI) has been widely utilized to study the motor deficits and rehabilitation following stroke. In particular, functional connectivity(FC) analyses with fMRI at rest can be employed to reveal the…

Neurons and Cognition · Quantitative Biology 2023-01-19 Kaichao Wu , Beth Jelfs , Katrina Neville , John Q. Fang

Unraveling how macroscopic cognitive phenotypes emerge from microscopic neuronal connectivity remains one of the core pursuits of neuroscience. To this end, researchers typically leverage multi-modal information from structural connectivity…

Artificial Intelligence · Computer Science 2026-02-03 Tianhao Huang , Guanghui Min , Zhenyu Lei , Aiying Zhang , Chen Chen

Objective motor skill assessment plays a critical role in fields such as surgery, where proficiency is vital for certification and patient safety. Existing assessment methods, however, rely heavily on subjective human judgment, which…

Neurons and Cognition · Quantitative Biology 2025-02-20 Anil Kamat , Rahul Rahul , Anirban Dutta , Lora Cavuoto , Uwe Kruger , Harry Burke , Matthew Hackett , Jack Norfleet , Steven Schwaitzberg , Suvranu De

Contemporary neuroscience has embraced network science to study the complex and self-organized structure of the human brain; one of the main outstanding issues is that of inferring from measure data, chiefly functional Magnetic Resonance…

Optimization and Control · Mathematics 2017-03-31 Giulia Prando , Mattia Zorzi , Alessandra Bertoldo , Alessandro Chiuso

We consider the challenges in extracting stimulus-related neural dynamics from other intrinsic processes and noise in naturalistic functional magnetic resonance imaging (fMRI). Most studies rely on inter-subject correlations (ISC) of…

Neurons and Cognition · Quantitative Biology 2021-02-23 Chee-Ming Ting , Jeremy I. Skipper , Steven L. Small , Hernando Ombao

Predicting disease states from functional brain connectivity is critical for the early diagnosis of severe neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. Existing studies commonly employ Graph Neural…

Machine Learning · Computer Science 2025-04-22 David Yang , Mostafa Abdelmegeed , John Modl , Minjeong Kim

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

The brain is often studied from a network perspective, where functional activity is assessed using functional Magnetic Resonance Imaging (fMRI) to estimate connectivity between predefined neuronal regions. Functional connectivity can be…

Applications · Statistics 2025-07-22 Olivier Bisson , Yanis Aeschlimann , Samuel Deslauriers-Gauthier , Xavier Pennec
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