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Neural biomarkers that can classify or predict disease are of broad interest to the neurological and psychiatric communities. Such biomarkers can be informative of disease state or treatment efficacy, even before there are changes in…

Neurons and Cognition · Quantitative Biology 2024-10-10 Xiaoxiao Sun , Chongkun Zhao , Sharath Koorathota , Paul Sajda

We present a didactic introduction to spectral Dynamic Causal Modelling (DCM), a Bayesian state-space modelling approach used to infer effective connectivity from non-invasive neuroimaging data. Spectral DCM is currently the most widely…

Neurons and Cognition · Quantitative Biology 2023-09-07 Leonardo Novelli , Karl Friston , Adeel Razi

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

An important field of research in functional neuroimaging is the discovery of integrated, distributed brain systems and networks, whose different regions need to work in unison for normal functioning. The EEG is a non-invasive technique…

MRI-based modeling of brain networks has been widely used to understand functional and structural interactions and connections among brain regions, and factors that affect them, such as brain development and disease. Graph mining on brain…

Machine Learning · Computer Science 2022-05-18 Haoteng Tang , Xiyao Fu , Lei Guo , Yalin Wang , Scott Mackin , Olusola Ajilore , Alex Leow , Paul Thompson , Heng Huang , Liang Zhan

The anatomical structure of the brain can be observed via non-invasive techniques such as diffusion imaging. However, these are imperfect because they miss connections that are actually known to exist, especially long range…

Neurons and Cognition · Quantitative Biology 2015-02-25 Somwrita Sarkar , Sanjay Chawla , Donna Xu

Dynamic functional connectivity (DFC) analysis involves measuring correlated neural activity over time across multiple brain regions. Significant regional correlations among neural signals, such as those obtained from resting-state…

A central question in neuroscience is how self-organizing dynamic interactions in the brain emerge on their relatively static structural backbone. Due to the complexity of spatial and temporal dependencies between different brain areas,…

Neurons and Cognition · Quantitative Biology 2020-10-15 Simon Wein , Wilhelm Malloni , Ana Maria Tomé , Sebastian M. Frank , Gina-Isabelle Henze , Stefan Wüst , Mark W. Greenlee , Elmar W. Lang

Neuroscientific studies aim to find an accurate and reliable brain Effective Connectome (EC). Although current EC discovery methods have contributed to our understanding of brain organization, their performances are severely constrained by…

Machine Learning · Computer Science 2024-03-12 Abdolmahdi Bagheri , Mahdi Dehshiri , Yamin Bagheri , Alireza Akhondi-Asl , Babak Nadjar Araabi

Functional connectivity (FC) derived from resting-state fMRI plays a critical role in personalized predictions such as age and cognitive performance. However, applying foundation models(FM) to fMRI data remains challenging due to its high…

Neurons and Cognition · Quantitative Biology 2025-08-26 Yanwen Wang , Xinglin Zhao , Yijin Song , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Measuring transient functional connectivity is an important challenge in Electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high temporal resolution is…

Neurons and Cognition · Quantitative Biology 2025-02-11 Om Roy , Yashar Moshfeghi , Agustin Ibanez , Francisco Lopera , Mario A Parra , Keith M Smith

As the field of connectomics has matured, it has expanded from mapping the existence of connections between brain components to measuring the strength of connections. This information is increasingly accessible via methodologies such as…

Neurons and Cognition · Quantitative Biology 2021-03-30 Daniel Graham

In this work we use numerical simulation to investigate how the temporal length of the data affects the reliability of the estimates of brain connectivity from EEG time--series. We assume that the neural sources follow a stable MultiVariate…

Quantitative Methods · Quantitative Biology 2017-11-10 Sara Sommariva , Alberto Sorrentino , Michele Piana , Vittorio Pizzella , Laura Marzetti

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi

This paper proposes a novel approach of integrating different neuroimaging techniques to characterize an autistic brain. Different techniques like EEG, fMRI and DTI have traditionally been used to find biomarkers for autism, but there have…

Predicting cognition from neuroimaging data in healthy individuals offers insights into the neural mechanisms underlying cognitive abilities, with potential applications in precision medicine and early detection of neurological and…

Machine Learning · Computer Science 2025-07-29 Jagruti Patel , Mikkel Schöttner , Thomas A. W. Bolton , Patric Hagmann

This paper introduces a novel approach for modelling time-varying connectivity in neuroimaging data, focusing on the slow fluctuations in synaptic efficacy that mediate neuronal dynamics. Building on the framework of Dynamic Causal…

Neurons and Cognition · Quantitative Biology 2024-12-05 Johan Medrano , Karl J. Friston , Peter Zeidman

The literature manifests that schizophrenia is associated with alterations in brain network connectivity. We investigate whether large-scale Extended Granger Causality (lsXGC) can capture such alterations using resting-state fMRI data. Our…

Neurons and Cognition · Quantitative Biology 2021-01-27 Axel Wismüller , M. Ali Vosoughi

Large-scale neuroimaging studies often collect data from multiple scanners across different sites, where variations in scanners, scanning procedures, and other conditions across sites can introduce artificial site effects. These effects may…

Methodology · Statistics 2026-05-26 Rongqian Zhang , Elena Tuzhilina , Jun Young Park

This paper investigates prefrontal cortex (PFC) functional connectivity based on synchronized electrical and hemodynamic responses associated with mental stress. The electrical response was based on alpha rhythmic of Electroencephalography…

Neurons and Cognition · Quantitative Biology 2021-03-09 Fares Al-Shargie