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Multiple technologies that measure expression levels of protein mixtures in the human body offer a potential for detection and understanding the disease. The recent increase of these technologies prompts researchers to evaluate the…

Machine Learning · Computer Science 2026-05-12 Michal Valko , Richard Pelikan , Miloš Hauskrecht

This chapter deals with approaches for protein three-dimensional structure prediction, starting out from a single input sequence with unknown struc- ture, the 'query' or 'target' sequence. Both template based and template free modelling…

Biomolecules · Quantitative Biology 2017-12-04 Sanne Abeln , Jaap Heringa , K. Anton Feenstra

Point clouds are a general format for representing realistic 3D objects in diverse 3D applications. Since point clouds have large data sizes, developing efficient point cloud compression methods is crucial. However, excessive compression…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Ryosuke Watanabe , Shashank N. Sridhara , Haoran Hong , Eduardo Pavez , Keisuke Nonaka , Tatsuya Kobayashi , Antonio Ortega

A computationally-simplified and descriptor-richer Point Cloud Quality Assessment (PCQA) metric, namely PointPCA+, is proposed in this paper, which is an extension of PointPCA. PointPCA proposed a set of perceptually-relevant descriptors…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Xuemei Zhou , Evangelos Alexiou , Irene Viola , Pablo Cesar

Full-reference (FR) image quality assessment (IQA) models assume a high quality "pristine" image as a reference against which to measure perceptual image quality. In many applications, however, the assumption that the reference image is of…

Image and Video Processing · Electrical Eng. & Systems 2018-02-12 Xiangxu Yu , Christos G. Bampis , Praful Gupta , Alan C. Bovik

Deep learning has become a crucial tool in studying proteins. While the significance of modeling protein structure has been discussed extensively in the literature, amino acid types are typically included in the input as a default operation…

Quantitative Methods · Quantitative Biology 2024-07-01 Yang Tan , Lirong Zheng , Bozitao Zhong , Liang Hong , Bingxin Zhou

Process mining techniques can help organizations to improve their operational processes. Organizations can benefit from process mining techniques in finding and amending the root causes of performance or compliance problems. Considering the…

Machine Learning · Computer Science 2021-08-18 Mahnaz Sadat Qafari , Wil van der Aalst

Motivation: Mass spectrometry-based proteomics is among the most commonly used methods for scrutinizing proteomic profiles in different organs for biological or medical researches. All the proteomic analyses including peptide/protein…

Quantitative Methods · Quantitative Biology 2017-11-01 Chunwei Ma

Quality assessment and aesthetics assessment aim to evaluate the perceived quality and aesthetics of visual content. Current learning-based methods suffer greatly from the scarcity of labeled data and usually perform sub-optimally in terms…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Qizhi Xie , Kun Yuan , Yunpeng Qu , Mingda Wu , Ming Sun , Chao Zhou , Jihong Zhu

Proteins are complex molecules responsible for different functions in nature. Enhancing the functionality of proteins and cellular fitness can significantly impact various industries. However, protein optimization using computational…

Machine Learning · Computer Science 2024-05-30 Minji Lee , Luiz Felipe Vecchietti , Hyunkyu Jung , Hyun Joo Ro , Meeyoung Cha , Ho Min Kim

Background: The increasing volume and variety of genotypic and phenotypic data is a major defining characteristic of modern biomedical sciences. At the same time, the limitations in technology for generating data and the inherently…

Quantitative Methods · Quantitative Biology 2016-12-07 Yuxiang Jiang , Tal Ronnen Oron , Wyatt T Clark , Asma R Bankapur , Daniel D'Andrea , Rosalba Lepore , Christopher S Funk , Indika Kahanda , Karin M Verspoor , Asa Ben-Hur , Emily Koo , Duncan Penfold-Brown , Dennis Shasha , Noah Youngs , Richard Bonneau , Alexandra Lin , Sayed ME Sahraeian , Pier Luigi Martelli , Giuseppe Profiti , Rita Casadio , Renzhi Cao , Zhaolong Zhong , Jianlin Cheng , Adrian Altenhoff , Nives Skunca , Christophe Dessimoz , Tunca Dogan , Kai Hakala , Suwisa Kaewphan , Farrokh Mehryary , Tapio Salakoski , Filip Ginter , Hai Fang , Ben Smithers , Matt Oates , Julian Gough , Petri Törönen , Patrik Koskinen , Liisa Holm , Ching-Tai Chen , Wen-Lian Hsu , Kevin Bryson , Domenico Cozzetto , Federico Minneci , David T Jones , Samuel Chapman , Dukka B K. C. , Ishita K Khan , Daisuke Kihara , Dan Ofer , Nadav Rappoport , Amos Stern , Elena Cibrian-Uhalte , Paul Denny , Rebecca E Foulger , Reija Hieta , Duncan Legge , Ruth C Lovering , Michele Magrane , Anna N Melidoni , Prudence Mutowo-Meullenet , Klemens Pichler , Aleksandra Shypitsyna , Biao Li , Pooya Zakeri , Sarah ElShal , Léon-Charles Tranchevent , Sayoni Das , Natalie L Dawson , David Lee , Jonathan G Lees , Ian Sillitoe , Prajwal Bhat , Tamás Nepusz , Alfonso E Romero , Rajkumar Sasidharan , Haixuan Yang , Alberto Paccanaro , Jesse Gillis , Adriana E Sedeño-Cortés , Paul Pavlidis , Shou Feng , Juan M Cejuela , Tatyana Goldberg , Tobias Hamp , Lothar Richter , Asaf Salamov , Toni Gabaldon , Marina Marcet-Houben , Fran Supek , Qingtian Gong , Wei Ning , Yuanpeng Zhou , Weidong Tian , Marco Falda , Paolo Fontana , Enrico Lavezzo , Stefano Toppo , Carlo Ferrari , Manuel Giollo , Damiano Piovesan , Silvio Tosatto , Angela del Pozo , José M Fernández , Paolo Maietta , Alfonso Valencia , Michael L Tress , Alfredo Benso , Stefano Di Carlo , Gianfranco Politano , Alessandro Savino , Hafeez Ur Rehman , Matteo Re , Marco Mesiti , Giorgio Valentini , Joachim W Bargsten , Aalt DJ van Dijk , Branislava Gemovic , Sanja Glisic , Vladmir Perovic , Veljko Veljkovic , Nevena Veljkovic , Danillo C Almeida-e-Silva , Ricardo ZN Vencio , Malvika Sharan , Jörg Vogel , Lakesh Kansakar , Shanshan Zhang , Slobodan Vucetic , Zheng Wang , Michael JE Sternberg , Mark N Wass , Rachael P Huntley , Maria J Martin , Claire O'Donovan , Peter N Robinson , Yves Moreau , Anna Tramontano , Patricia C Babbitt , Steven E Brenner , Michal Linial , Christine A Orengo , Burkhard Rost , Casey S Greene , Sean D Mooney , Iddo Friedberg , Predrag Radivojac

Recurrence quantification analysis (RQA) is a widely used tool for studying complex dynamical systems, but its standard implementation requires computationally expensive calculations of recurrence plots (RPs) and line length histograms.…

Chaotic Dynamics · Physics 2026-01-06 Norbert Marwan

Enzyme engineering enables the modification of wild-type proteins to meet industrial and research demands by enhancing catalytic activity, stability, binding affinities, and other properties. The emergence of deep learning methods for…

Computation and Language · Computer Science 2024-10-29 Yang Tan , Ruilin Wang , Banghao Wu , Liang Hong , Bingxin Zhou

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

Machine-learning interatomic potentials are widely used as computationally efficient surrogates for density functional theory in atomistic simulations, enabling large-scale, long-time modeling of materials systems. We investigate how…

Materials Science · Physics 2026-04-13 Jonas Grandel , Philipp Benner , Janine George

This paper describes our contributions to the Shared Task of the 9th Workshop on Argument Mining (2022). Our approach uses Large Language Models for the task of Argument Quality Prediction. We perform prompt engineering using GPT-3, and…

Computation and Language · Computer Science 2022-10-06 Michiel van der Meer , Myrthe Reuver , Urja Khurana , Lea Krause , Selene Báez Santamaría

We present a proof of concept that machine learning techniques can be used to predict the properties of CNOHF energetic molecules from their molecular structures. We focus on a small but diverse dataset consisting of 109 molecular…

Materials Science · Physics 2018-06-14 Daniel C. Elton , Zois Boukouvalas , Mark S. Butrico , Mark D. Fuge , Peter W. Chung

Many important problems involving molecular property prediction from 3D structures have limited data, posing a generalization challenge for neural networks. In this paper, we describe a pre-training technique based on denoising that…

This paper proposes a novel training method to improve the robustness of Extractive Question Answering (EQA) models. Previous research has shown that existing models, when trained on EQA datasets that include unanswerable questions,…

Computation and Language · Computer Science 2024-10-01 Son Quoc Tran , Matt Kretchmar

This paper discusses an approach with machine-learning probability models to evaluate the difference between good and bad data quality in a dataset. A decision tree algorithm is used to predict data quality based on no domain knowledge of…

Machine Learning · Computer Science 2020-09-16 Allen ONeill