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In this essay we elaborate on recent evidence demonstrating the presence of a second order phase transition in human brain dynamics and discuss its consequences for theoretical approaches to brain function. We review early evidence of…

Neurons and Cognition · Quantitative Biology 2015-06-12 Enzo Tagliazucchi , Dante R. Chialvo

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

In recent years, human behavior simulation has drawn increasing attention from both academia and industry. The reasons fall into two aspects. First, simulation serves as a critical tool for understanding human behaviors, which has become…

Human-Computer Interaction · Computer Science 2024-12-12 Zhang Guozhen , Yu Zihan , Li Nian , Yu Fudan , Long Qingyue , Jin Depeng , Li Yong

A major challenge in neuroscience is posed by the need for relating the emerging dynamical features of brain activity with the underlying modular structure of neural connections, hierarchically organized throughout several scales. The…

Neurons and Cognition · Quantitative Biology 2016-06-03 Pablo Villegas , Jorge Hidalgo , Paolo Moretti , Miguel A. Muñoz

Mapping the functional connectome has the potential to uncover key insights into brain organisation. However, existing workflows for functional connectomics are limited in their adaptability to new data, and principled workflow design is a…

Neurons and Cognition · Quantitative Biology 2022-06-02 Rastko Ciric , Armin W. Thomas , Oscar Esteban , Russell A. Poldrack

The human connectome at the level of fiber tracts between brain regions has been shown to differ in patients with brain disorders compared to healthy control groups. Nonetheless, there is a potentially large number of different network…

Neurons and Cognition · Quantitative Biology 2013-10-16 Marcus Kaiser

The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…

The incorporation of neuroimaging techniques such as electroenchephalography (EEG) and functional near-infrared spectroscopy (fNIRS) has provided new opportunities for the analysis of dynamic brain processes involved in cognitive and motor…

Neurons and Cognition · Quantitative Biology 2026-03-25 Zaineb Ajra , Grégoire Vergotte , Stéphane Perrey , Lilian Evra , Simon Pla , Gérard Dray , Jacky Montmain , Binbin Xu

Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions, however it is unclear how this mechanism manifests over time. In this study, we use time-resolved network…

Learning about the causal structure of the world is a fundamental problem for human cognition. Causal models and especially causal learning have proved to be difficult for large pretrained models using standard techniques of deep learning.…

Artificial Intelligence · Computer Science 2026-04-16 Eunice Yiu , Kelsey Allen , Shiry Ginosar , Alison Gopnik

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…

From interacting cellular components to networks of neurons and neural systems, interconnected units comprise a fundamental organizing principle of the nervous system. Understanding how their patterns of connections and interactions give…

Neurons and Cognition · Quantitative Biology 2018-08-01 Danielle S. Bassett , Perry Zurn , Joshua I. Gold

This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models…

Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. Here, we first describe emerging tools and…

Neurons and Cognition · Quantitative Biology 2022-01-10 Anne E. Urai , Brent Doiron , Andrew M. Leifer , Anne K. Churchland

It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization…

Neurons and Cognition · Quantitative Biology 2017-01-11 R. Guevara Erra , D. M. Mateos , R. Wennberg , J. L. Perez Velazquez

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network structure does not entail that the brain actually works as a network. Asking whether the…

Neurons and Cognition · Quantitative Biology 2024-12-24 D. Papo , J. M. Buldú

Brain foundation models (BFMs) have emerged as a transformative paradigm in computational neuroscience, offering a revolutionary framework for processing diverse neural signals across different brain-related tasks. These models leverage…

Machine Learning · Computer Science 2025-07-22 Xinliang Zhou , Chenyu Liu , Zhisheng Chen , Kun Wang , Yi Ding , Ziyu Jia , Qingsong Wen

Recent studies in neuroscience highlight the significant potential of brain connectivity networks, which are commonly constructed from functional magnetic resonance imaging (fMRI) data for brain disorder diagnosis. Traditional brain…

The notion of causality assumes a paramount position within the realm of human cognition. Over the past few decades, there has been significant advancement in the domain of causal effect estimation across various disciplines, including but…

Machine Learning · Statistics 2024-05-24 Zongyu Li , Xiaobo Guo , Siwei Qiang