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Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

Methodology · Statistics 2018-05-07 Bochao Jia

Linear mixed-effects model (LMM) is a cornerstone of longitudinal data analysis, but is limited to adeptly make heterogeneous analyses predictable under both group-specific fixed effects and subject-specific random effects. To address this…

Methodology · Statistics 2026-03-10 Xinkai Yue , Xiaodong Yan , Haohui Han , Liya Fu

The problem of machine learning with missing values is common in many areas. A simple approach is to first construct a dataset without missing values simply by discarding instances with missing entries or by imputing a fixed value for each…

Machine Learning · Statistics 2018-03-02 Hiroyuki Hanada , Toshiyuki Takada , Jun Sakuma , Ichiro Takeuchi

Multivariate time series data play a pivotal role in a wide range of real-world applications. However, the presence of block missing data introduces significant challenges, often compromising the performance of predictive models.…

Machine Learning · Computer Science 2025-03-04 Jing Peng , Meiqi Yang , Qiong Zhang , Xiaoxiao Li

Image data are increasingly encountered and are of growing importance in many areas of science. Much of these data are quantitative image data, which are characterized by intensities that represent some measurement of interest in the…

Missing data are inevitable in longitudinal studies. Traditional methods, such as the full information maximum likelihood (FIML), are commonly used to handle ignorable missing data. However, they may lead to biased model estimation due to…

Applications · Statistics 2024-01-01 Dandan Tang , Xin Tong

Data for several applications in diverse fields can be represented as multiple matrices that are linked across rows or columns. This is particularly common in molecular biomedical research, in which multiple molecular "omics" technologies…

Machine Learning · Statistics 2024-08-02 Eric F. Lock

We illustrate a class of conditional models for the analysis of longitudinal data suffering attrition in random effects models framework, where the subject-specific random effects are assumed to be discrete and to follow a time-dependent…

Methodology · Statistics 2014-04-28 Antonello Maruotti

Missing values challenge data analysis because many supervised and unsupervised learning methods cannot be applied directly to incomplete data. Matrix completion based on low-rank assumptions are very powerful solution for dealing with…

Machine Learning · Statistics 2020-01-30 Aude Sportisse , Claire Boyer , Julie Josse

In longitudinal data a response variable is measured over time, or under different conditions, for a cohort of individuals. In many situations all intended measurements are not available which results in missing values. If the missing value…

Methodology · Statistics 2022-08-10 Ahmed M. Gad , Nesma M. Darwish

Electronic health record (EHR)-linked biobank data hold tremendous promise for large-scale discoveries via genome-wide association study (GWAS) on diverse phenotypic traits and biomarkers routinely captured in the EHR. However,…

Applications · Statistics 2026-04-14 Xingran Chen , Cheng-Han Yang , Zhenke Wu , Bhramar Mukherjee

The ultimate target of proteomics identification is to identify and quantify the protein in the organism. Mass spectrometry (MS) based on label-free protein quantitation has mainly focused on analysis of peptide spectral counts and ion peak…

Quantitative Methods · Quantitative Biology 2013-12-05 Biao He , Baochang Zhang , Yan Fu

Case-cohort studies are conducted within cohort studies, wherein collection of exposure data is limited to a subset of the cohort, leading to a large proportion of missing data by design. Standard analysis uses inverse probability weighting…

Spurred in part by the ever-growing number of sensors and web-based methods of collecting data, the use of Intensive Longitudinal Data (ILD) is becoming more common in the social and behavioural sciences. The ILD collected in this field are…

Methodology · Statistics 2022-01-25 Jasper Ginn , Sebastian Mildiner Moraga , Emmeke Aarts

Electronic health record (EHR) data is sparse and irregular as it is recorded at irregular time intervals, and different clinical variables are measured at each observation point. In this work, we propose a multi-view features integration…

Machine Learning · Computer Science 2021-01-27 Yurim Lee , Eunji Jun , Heung-Il Suk

For large-scale testing with graph-associated data, we present an empirical Bayes mixture technique to score local false discovery rates. Compared to empirical Bayes procedures that ignore the graph, the proposed method gains power in…

Methodology · Statistics 2019-11-26 TIen Vo , Vamsi Ithapu , Vikas Singh , Michael A. Newton

Clinical randomized controlled trials (RCTs) collect hundreds of measurements spanning various metric types (e.g., laboratory tests, cognitive/motor assessments, etc.) across 100s-1000s of subjects to evaluate the effect of a treatment, but…

Machine Learning · Computer Science 2024-06-25 Sayeri Lala , Niraj K. Jha

The time series cluster kernel (TCK) provides a powerful tool for analysing multivariate time series subject to missing data. TCK is designed using an ensemble learning approach in which Bayesian mixture models form the base models. Because…

Machine Learning · Computer Science 2019-07-12 Karl Øyvind Mikalsen , Cristina Soguero-Ruiz , Filippo Maria Bianchi , Arthur Revhaug , Robert Jenssen

Longitudinal data are essential for studying within subject change and between subject differences in change. However, missing data, especially when the observed variables are nonnormal, remain a significant challenge in longitudinal…

Methodology · Statistics 2025-04-21 Dandan Tang , Xin Tong , Jianhui Zhou

The Information bottleneck method is an unsupervised non-parametric data organization technique. Given a joint distribution P(A,B), this method constructs a new variable T that extracts partitions, or clusters, over the values of A that are…

Machine Learning · Computer Science 2013-01-14 Nir Friedman , Ori Mosenzon , Noam Slonim , Naftali Tishby
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