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Inferring the directionality of interactions between cellular processes is a major challenge in systems biology. Time-lagged correlations allow to discriminate between alternative models, but they still rely on assumed underlying…

Quantitative Methods · Quantitative Biology 2017-11-15 Sourabh Lahiri , Philippe Nghe , Sander J. Tans , Martin Luc Rosinberg , David Lacoste

Fluctuations strongly affect the dynamics and functionality of nanoscale thermal machines. Recent developments in stochastic thermodynamics have shown that fluctuations in many far-from-equilibrium systems are constrained by the rate of…

Quantum Physics · Physics 2021-01-29 Antoine Rignon-Bret , Giacomo Guarnieri , John Goold , Mark T. Mitchison

Fluctuation relations allow for the computation of equilibrium properties, like free energy, from an ensemble of non-equilibrium dynamics simulations. Computing them for quantum systems, however, can be difficult, as performing dynamic…

Quantum Physics · Physics 2021-09-07 Lindsay Bassman , Katherine Klymko , Diyi Liu , Norman M. Tubman , Wibe A. de Jong

Gibbs and Boltzmann definitions of temperature agree only in the macroscopic limit. The ambiguity in identifying the equilibrium temperature of a finite sized `small' system exchanging energy with a bath is usually understood as a…

Biological Physics · Physics 2015-03-09 Purushottam D. Dixit

Thermodynamics constrains changes to the energy of a system, both deliberate and random, via its first and second laws. When the system is not in equilibrium, fluctuation theorems such as the Jarzynski equality further restrict the…

The fundamental insight into Brownian motion by Einstein is that all substances exhibit continual fluctuations due to thermal agitation balancing with the frictional resistance. However, even at thermal equilibrium, biological activity can…

Soft Condensed Matter · Physics 2014-02-19 Soya Shinkai , Yuichi Togashi

Temperature of a finite-sized system fluctuates due to the thermal fluctuations. However, a systematic mathematical framework for measuring or estimating the temperature is still underdeveloped. Here, we incorporate the estimation theory in…

Statistical Mechanics · Physics 2026-03-17 Shaoyong Zhang , Zhaoyu Fei , Xiaoguang Wang

We review the consequences of intrinsic, nonstatistical temperature fluctuations as seen in observables measured in high energy collisions. We do this from the point of view of nonextensive statistics and Tsallis distributions. Particular…

High Energy Physics - Phenomenology · Physics 2015-06-04 Grzegorz Wilk , Zbigniew Wlodarczyk

Fluctuations play a central role in many fields of physics, from quantum electrodynamics to statistical mechanics. In active matter physics, most models focus on thermal fluctuations due to a surrounding solvent. An alternative but much…

Soft Condensed Matter · Physics 2025-04-17 Sebastian Fehlinger , Kai Cui , Arooj Sajjad , Heinz Koeppl , Benno Liebchen

The application of the conventional theory of macroparameter fluctuations has been shown to go beyond the framework of the thermodynamic description in a number of cases. The principles of the theory of quantum-thermal fluctuations of…

Statistical Mechanics · Physics 2011-12-09 A. D. Sukhanov , O. N. Golubjeva , V. G. Baryakhtar

In this perspective we consider how modern statistical mechanics and response theory can be applied to understand the response of polar molecules to an applied electric field and the fluctuations in these systems. Results that are…

Statistical Mechanics · Physics 2024-01-08 Debra J. Searles , Stephen Sanderson

We compare the fluctuation relations for work and entropy in underdamped and overdamped systems, when the friction coefficient of the medium is space-dependent. We find that these relations remain unaffected in both cases. However, for the…

Statistical Mechanics · Physics 2015-06-15 Sourabh Lahiri , Shubhashis Rana , A. M. Jayannavar

Recent advances in non-equilibrium statistical mechanics and single molecule technologies make it possible to extract free energy differences from irreversible work measurements in pulling experiments. To date, free energy recovery has been…

Biological Physics · Physics 2013-04-04 Anna Alemany , Alessandro Mossa , Ivan Junier , Felix Ritort

Mesoscopic systems -- small electric circuits working in quantum regime -- offer us a unique experimental stage to explorer quantum transport in a tunable and precise way. The purpose of this Review is to show how they can contribute to…

Mesoscale and Nanoscale Physics · Physics 2017-05-12 Kensuke Kobayashi

Thermodynamics is a highly successful macroscopic theory widely used across the natural sciences and for the construction of everyday devices, from car engines and fridges to power plants and solar cells. With thermodynamics predating…

Quantum Physics · Physics 2016-04-07 Philipp Kammerlander , Janet Anders

We experimentally demonstrate that highly structured distributions of work emerge during even the simple task of erasing a single bit. These are signatures of a refined suite of time-reversal symmetries in distinct functional classes of…

We study temperature fluctuations in mesoscopic $N$-body systems undergoing non-equilibrium processes from the perspective of stochastic thermodynamics. By introducing a stochastic differential equation, we describe the evolution of the…

Statistical Mechanics · Physics 2026-05-19 Zhaoyu Fei , Yu-Han Ma

The energy cost of computation has emerged as a central challenge at the intersection of physics and computer science. Recent advances in statistical physics -- particularly in stochastic thermodynamics -- enable precise characterizations…

Statistical Mechanics · Physics 2025-10-07 Jinghao Lyu , Kyle J. Ray , James P. Crutchfield

Thermodynamics is usually formulated on the presumption that the observer has complete information about the system he/she deals with: no parasitic current, exact evaluation of the forces that drive the system. For example, the acclaimed…

Statistical Mechanics · Physics 2017-12-15 Matteo Polettini , Massimiliano Esposito

The nonequilibrium fluctuation theorems have paved the way for estimating equilibrium thermodynamic properties, such as free energy differences, using trajectories from driven nonequilibrium processes. While many statistical estimators may…

Statistical Mechanics · Physics 2012-08-27 David D. L. Minh , Suriyanarayanan Vaikuntanathan