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We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown {\it in vitro}. We infer connectivity between two…

Neurons and Cognition · Quantitative Biology 2007-05-23 Luis M. A. Bettencourt , Greg J. Stephens , Michael I. Ham , Guenter W. Gross

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

This article presents a review of computational methods for connectivity inference from neural activity data derived from multi-electrode recordings or fluorescence imaging. We first identify biophysical and technical challenges in…

Neurons and Cognition · Quantitative Biology 2017-12-18 Ildefons Magrans de Abril , Junichiro Yoshimoto , Kenji Doya

Lattice field theories are fundamental testbeds for computational physics; yet, sampling their Boltzmann distributions remains challenging due to multimodality and long-range correlations. While normalizing flows offer a promising…

Machine Learning · Computer Science 2025-10-16 Andrey Bryutkin , Youssef Marzouk

Resting-state functional MRI (rs-fMRI) is widely used to noninvasively study human brain networks. Network functional connectivity is often estimated by calculating the timeseries correlation between blood-oxygen-level dependent (BOLD)…

Quantitative Methods · Quantitative Biology 2017-01-25 Nan Xu , R. Nathan Spreng , Peter C. Doerschuk

Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set…

Applications · Statistics 2012-02-07 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

Graph connectivity is a fundamental combinatorial optimization problem that arises in many practical applications, where usually a spanning subgraph of a network is used for its operation. However, in the real world, links may fail…

Data Structures and Algorithms · Computer Science 2022-09-13 Dimitris Fotakis , Evangelia Gergatsouli , Charilaos Pipis , Miltiadis Stouras , Christos Tzamos

Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

One of the central challenges facing modern neuroscience is to explain the ability of the nervous system to coherently integrate information across distinct functional modules in the absence of a central executive. To this end Tononi et al.…

Neurons and Cognition · Quantitative Biology 2010-11-30 L. Barnett , C. L. Buckley , S. Bullock

The brain is a highly complex system. Most of such complexity stems from the intermingled connections between its parts, which give rise to rich dynamics and to the emergence of high-level cognitive functions. Disentangling the underlying…

Neurons and Cognition · Quantitative Biology 2023-08-14 Vito Dichio , Fabrizio De Vico Fallani

The exploration of Graph Neural Networks (GNNs) for processing graph-structured data has expanded, particularly their potential for causal analysis due to their universal approximation capabilities. Anticipated to significantly enhance…

Machine Learning · Computer Science 2024-01-30 Simi Job , Xiaohui Tao , Taotao Cai , Lin Li , Haoran Xie , Jianming Yong

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

We present an algorithm to identify sparse dependence structure in continuous and non-Gaussian probability distributions, given a corresponding set of data. The conditional independence structure of an arbitrary distribution can be…

Machine Learning · Computer Science 2017-11-07 Rebecca E. Morrison , Ricardo Baptista , Youssef Marzouk

Recent studies proposed the use of Total Correlation to describe functional connectivity among brain regions as a multivariate alternative to conventional pair-wise measures such as correlation or mutual information. In this work we build…

Neurons and Cognition · Quantitative Biology 2022-11-28 Qiang Li , Greg Ver Steeg , Shujian Yu , Jesus Malo

While correlation measures are used to discern statistical relationships between observed variables in almost all branches of data-driven scientific inquiry, what we are really interested in is the existence of causal dependence. Designing…

Machine Learning · Computer Science 2014-06-26 Ishanu Chattopadhyay

Neural networks are often represented as graphs of connections between neurons. However, despite their wide use, there is currently little understanding of the relationship between the graph structure of the neural network and its…

Machine Learning · Computer Science 2020-08-28 Jiaxuan You , Jure Leskovec , Kaiming He , Saining Xie

With the advancements in graph neural network, there has been increasing interest in applying this network to ECG signal analysis. In this study, we generated an adjacency matrix using correlation matrix of extracted features and applied a…

Signal Processing · Electrical Eng. & Systems 2025-02-11 Seungwoo Han

This article focuses on the problem of studying shared- and individual-specific structure in replicated networks or graph-valued data. In particular, the observed data consist of $n$ graphs, $G_i, i=1,\ldots,n$, with each graph consisting…

Computation · Statistics 2018-04-13 Lu Wang , Zhengwu Zhang , David Dunson

Graph theory is a promising approach in handling the problem of estimating the connectivity probability of vehicular ad-hoc networks (VANETs). With a communication network represented as graph, graph connectivity indicators become valid for…

Networking and Internet Architecture · Computer Science 2023-05-03 Samar Elaraby , Sherif M. Abuelenin

Neural systems are networks, and strategic comparisons between multiple networks are a prevalent task in many research scenarios. In this study, we construct a statistical test for the comparison of matrices representing pairwise aspects of…

Neurons and Cognition · Quantitative Biology 2023-02-08 Robin Gutzen , Sonja Grün , Michael Denker