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The effect of target molecule depletion from the supernatant solution is incorporated into a physico-chemical model of hybridisation on oligonucleotide microarrays. Two possible regimes are identified: local depletion, in which depletion by…

Genomics · Quantitative Biology 2009-11-17 Conrad J. Burden , Hans Binder

A single model is presented which represents both of the two apparently unrelated localisation problems of the title. The phase diagram of this model is examined using scaling ideas and numerical simulations. It is argued that the…

Condensed Matter · Physics 2011-08-05 D. K. K. Lee , J. T. Chalker

We show that a mesoscale model, with a minimal number of parameters, can well describe the thermomechanical and mechanochemical behavior of homogeneous DNA at thermal equilibrium under tension and torque. We predict critical temperatures…

Biomolecules · Quantitative Biology 2015-06-22 Cristiano Nisoli , A. R. Bishop

The Peierls-Nabarro (PN) model for dislocations is a hybrid model that incorporates the atomistic information of the dislocation core structure into the continuum theory. In this paper, we study the convergence from a full atomistic model…

Analysis of PDEs · Mathematics 2018-06-13 Tao Luo , Pingbing Ming , Yang Xiang

A molecular dynamics simulation of the demixing process of a binary complex plasma is analysed and the role of distinct interaction potentials is discussed by using morphological Minkowski tensor analysis of the minority phase domain growth…

Plasma Physics · Physics 2016-08-03 Alexander Böbel , Christoph Räth

We revisit the popular notion of effective or renormalized charge, which is a concept of central importance in the field of highly charged colloidal or polyelectrolyte solutions. Working at the level of a linear Debye-H\"uckel like theory…

Soft Condensed Matter · Physics 2009-11-07 Emmanuel Trizac , Lyderic Bocquet , Miguel Aubouy

This paper studies the discretization of a homogenization and dimension reduction model for the elastic deformation of microstructured thin plates proposed by Hornung, Neukamm, and Vel\v{c}i\'c in 2014. Thereby, a nonlinear bending energy…

Numerical Analysis · Mathematics 2024-06-19 Martin Rumpf , Stefan Simon , Christoph Smoch

We consider a general model of a heterogeneous polymer chain fluctuating in the proximity of an interface between two selective solvents. The heterogeneous character of the model comes from the fact that the monomer units interact with the…

Probability · Mathematics 2009-09-29 Francesco Caravenna , Giambattista Giacomin , Lorenzo Zambotti

We discuss the effects of external stress on the thermal denaturation of homogeneous DNA. Pulling double-stranded DNA at each end exerts a profound effect on the thermal denaturation, or melting, of a long segment of this molecule. We…

Soft Condensed Matter · Physics 2009-11-13 Joseph Rudnick , Tatiana Kuriabova

For two-scale homogenization of a general class of asymptotically degenerating %uniformly strongly elliptic symmetric PDE systems with a critically scaled high contrast in periodic coefficients of a small period $\varepsilon$, we derive a…

Analysis of PDEs · Mathematics 2017-11-27 I. V. Kamotski , V. P. Smyshlyaev

The paper compares the statistical description of physical-metallurgical processes and ceramic-polycrystalline evolutions, termed the normal grain growth (NGG), as adopted to soft- and chemically-reactive grains, with a Smoluchowski's…

Soft Condensed Matter · Physics 2018-08-08 Adam Gadomski , Natalia Kruszewska , Piotr Bełdowski , Bogdan Lent , Marcel Ausloos

The situation of the metastable phase decay on the several types of heterogeneous centers is considered. The method to spread the monodisperse approximation on the situation of the strong unsymmetry is presented. The simple analytical…

Statistical Mechanics · Physics 2007-05-23 V. Kurasov

We explore in detail the structural, mechanical and thermodynamic properties of a coarse-grained model of DNA similar to that introduced in Thomas E. Ouldridge, Ard A. Louis, Jonathan P.K. Doye, Phys. Rev. Lett. 104 178101 (2010). Effective…

Biomolecules · Quantitative Biology 2013-06-25 Thomas E. Ouldridge , Ard A. Louis , Jonathan P. K. Doye

The aim of the paper is to introduce an alternative notion of two-scale convergence which gives a more natural modeling approach to the homogenization of partial differential equations with periodically oscillating coefficients: while…

Analysis of PDEs · Mathematics 2016-07-20 François Alouges , Giovanni Di Fratta

While stretching of most polymer chains leads to rather featureless force-extension diagrams, some, notably DNA, exhibit non-trivial behavior with a distinct plateau region. Here we propose a unified theory that connects force-extension…

Mesoscale and Nanoscale Physics · Physics 2013-02-26 Alexander V. Savin , Mikhail A. Mazo , Irina P. Kikot , Alexey V. Onufriev

We consider the Dyson hierarchical version of the quantum Spin-Glass with random Gaussian couplings characterized by the power-law decaying variance $\overline{J^2(r)} \propto r^{-2\sigma}$ and a uniform transverse field $h$. The ground…

Disordered Systems and Neural Networks · Physics 2015-10-26 Cecile Monthus

We study Gibbs distributions of spins taking values in a general compact Polish space, interacting via a pair potential along the edges of a generalized random graph with a given asymptotic weight distribution $P$, obtained by annealing…

Probability · Mathematics 2016-10-27 Sander Dommers , Christof Kuelske , Philipp Schriever

The computational modelling of DNA is becoming crucial in light of new advances in DNA nanotechnology, single-molecule experiments and in vivo DNA tampering. Here we present a mesoscopic model for double stranded DNA (dsDNA) at the single…

Soft Condensed Matter · Physics 2025-02-03 Y. A. G. Fosado , D. Michieletto , J. Allan , C. Brackley , O. Henrich , D. Marenduzzo

This paper presents a numerical study of the dynamics of DNA double helix breakage under the influence of external forces using the Peyrard-Bishop-Dauxois (PBD) model. The PBD model represents DNA as a chain of nonlinearly coupled…

Biological Physics · Physics 2026-01-23 I. V. Likhachev , V. D. Lakhno

The particle-hole Density Matrix Renormalization Group (p-h DMRG) method is discussed as a possible new approach to large-scale nuclear shell-model calculations. Following a general description of the method, we apply it to a class of…

Nuclear Theory · Physics 2011-05-12 J. Dukelsky , S. Pittel , S. S. Dimitrova , M. V. Stoitsov