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To date, there are no effective treatments for most neurodegenerative diseases. However, certain foods may be associated with these diseases and bring an opportunity to prevent or delay neurodegenerative progression. Our objective is to…

Artificial Intelligence · Computer Science 2021-10-26 Yi Nian , Jingcheng Du , Larry Bu , Fang Li , Xinyue Hu , Yuji Zhang , Cui Tao

New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome,…

Quantitative Methods · Quantitative Biology 2018-10-22 Marinka Zitnik , Francis Nguyen , Bo Wang , Jure Leskovec , Anna Goldenberg , Michael M. Hoffman

Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance,…

Quantitative Methods · Quantitative Biology 2024-07-02 Rodrigo Dorantes-Gilardi , Kerry Ivey , Lauren Costa , Rachael Matty , Kelly Cho , John Michael Gaziano , Albert-László Barabási

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level.…

Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets),…

Quantitative Methods · Quantitative Biology 2020-07-28 Qianlong Wen , Ruoqi Liu , Ping Zhang

Disease name recognition and normalization, which is generally called biomedical entity linking, is a fundamental process in biomedical text mining. Recently, neural joint learning of both tasks has been proposed to utilize the mutual…

Computation and Language · Computer Science 2021-04-22 Shogo Ujiie , Hayate Iso , Shuntaro Yada , Shoko Wakamiya , Eiji Aramaki

Although the goal of achieving semantic interoperability of electronic health records (EHRs) is pursued by many researchers, it has not been accomplished yet. In this paper, we present a proposal that smoothes out the way toward the…

Artificial Intelligence · Computer Science 2024-01-23 Idoia Berges , Jesús Bermúdez , Arantza Illarramendi

Dietary intake data are routinely drawn upon to explore diet-health relationships. However, these data are often subject to measurement error, distorting the true relationships. Beyond measurement error, there are likely complex synergistic…

Machine Learning · Computer Science 2025-02-12 Dylan Spicker , Amir Nazemi , Joy Hutchinson , Paul Fieguth , Sharon I. Kirkpatrick , Michael Wallace , Kevin W. Dodd

Deep learning models have shown tremendous potential in learning representations, which are able to capture some key properties of the data. This makes them great candidates for transfer learning: Exploiting commonalities between different…

Electronic Health Records (EHRs) are pivotal in clinical practices, yet their retrieval remains a challenge mainly due to semantic gap issues. Recent advancements in dense retrieval offer promising solutions but existing models, both…

Information Retrieval · Computer Science 2025-07-25 Zhengyun Zhao , Huaiyuan Ying , Yue Zhong , Sheng Yu

Background: Access to medical care is strongly dependent on resource allocation, such as the geographical distribution of medical facilities. Nevertheless, this data is usually restricted to country official documentation, not available to…

Artificial Intelligence · Computer Science 2022-09-27 Selene Baez Santamaria , Emmanouil Manousogiannis , Guusje Boomgaard , Linh P. Tran , Zoltan Szlavik , Robert-Jan Sips

While coreference resolution is traditionally used as a component in individual document understanding, in this work we take a more global view and explore what can we learn about a domain from the set of all document-level coreference…

Computation and Language · Computer Science 2024-10-23 Shir Ashury-Tahan , Amir David Nissan Cohen , Nadav Cohen , Yoram Louzoun , Yoav Goldberg

Over the past decade, there has been a steep rise in the data-driven analysis in major areas of medicine, such as clinical decision support system, survival analysis, patient similarity analysis, image analytics etc. Most of the data in the…

Information Retrieval · Computer Science 2020-10-06 Sheikh Shams Azam , Manoj Raju , Venkatesh Pagidimarri , Vamsi Kasivajjala

Objective: Electronic medical records (EMRs) contain an amount of medical knowledge which can be used for clinical decision support (CDS). Our objective is a general system that can extract and represent these knowledge contained in EMRs to…

Artificial Intelligence · Computer Science 2017-09-21 Chao Zhao , Jingchi Jiang , Yi Guan

Missingness in variables that define study eligibility criteria is a seldom addressed challenge in electronic health record (EHR)-based settings. It is typically the case that patients with incomplete eligibility information are excluded…

In the context of personalized medicine, text mining methods pose an interesting option for identifying disease-gene associations, as they can be used to generate novel links between diseases and genes which may complement knowledge from…

Computation and Language · Computer Science 2017-09-28 Hendrik ter Horst , Matthias Hartung , Roman Klinger , Matthias Zwick , Philipp Cimiano

Although increasingly used as a data resource for assembling cohorts, electronic health records (EHRs) pose many analytic challenges. In particular, a patient's health status influences when and what data are recorded, generating sampling…

Methodology · Statistics 2020-04-28 Yifei Sun , Charles E. McCulloch , Kieren A. Marr , Chiung-Yu Huang

Predicting the health risks of patients using Electronic Health Records (EHR) has attracted considerable attention in recent years, especially with the development of deep learning techniques. Health risk refers to the probability of the…

Machine Learning · Computer Science 2022-11-15 Yuxi Liu , Shaowen Qin , Antonio Jimeno Yepes , Wei Shao , Zhenhao Zhang , Flora D. Salim

Biomedical research has revealed the crucial role of miRNAs in the progression of many diseases, and computational prediction methods are increasingly proposed for assisting biological experiments to verify miRNA-disease associations…

Computational Engineering, Finance, and Science · Computer Science 2023-08-29 Yi Zhou , Meixuan Wu , Chengzhou Ouyang , Min Zhu

Causal relation extraction of biomedical entities is one of the most complex tasks in biomedical text mining, which involves two kinds of information: entity relations and entity functions. One feasible approach is to take relation…

Computation and Language · Computer Science 2022-08-03 Dongling Li , Pengchao Wu , Yuehu Dong , Jinghang Gu , Longhua Qian , Guodong Zhou