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Understanding the distinction between causation and correlation is critical in Alzheimer's disease (AD) research, as it impacts diagnosis, treatment, and the identification of true disease drivers. This experiment investigates the…

Artificial Intelligence · Computer Science 2025-06-13 Hamzah Dabool , Raghad Mustafa

Understanding causal narratives communicated in clinical notes can help make strides towards personalized healthcare. Extracted causal information from clinical notes can be combined with structured EHR data such as patients' demographics,…

Computation and Language · Computer Science 2022-03-15 Vivek Khetan , Md Imbesat Hassan Rizvi , Jessica Huber , Paige Bartusiak , Bogdan Sacaleanu , Andrew Fano

The timely identification of socio-economic sectors vulnerable to a disease outbreak presents an important challenge to the civic authorities and healthcare workers interested in outbreak mitigation measures. This problem was traditionally…

Machine Learning · Computer Science 2021-10-28 Aboli Marathe , Harsh Sakhrani , Saloni Parekh

Medical information extraction consists of a group of natural language processing (NLP) tasks, which collaboratively convert clinical text to pre-defined structured formats. Current state-of-the-art (SOTA) NLP models are highly integrated…

Computation and Language · Computer Science 2022-03-09 Enwei Zhu , Qilin Sheng , Huanwan Yang , Jinpeng Li

Deep learning approaches have demonstrated remarkable progress in automatic Chest X-ray analysis. The data-driven feature of deep models requires training data to cover a large distribution. Therefore, it is substantial to integrate…

Computer Vision and Pattern Recognition · Computer Science 2020-06-09 Luyang Luo , Lequan Yu , Hao Chen , Quande Liu , Xi Wang , Jiaqi Xu , Pheng-Ann Heng

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman

Clinical text classification is an important problem in medical natural language processing. Existing studies have conventionally focused on rules or knowledge sources-based feature engineering, but only a few have exploited effective…

Computation and Language · Computer Science 2018-07-23 Liang Yao , Chengsheng Mao , Yuan Luo

Understanding epistasis (genetic interaction) may shed some light on the genomic basis of common diseases, including disorders of maximum interest due to their high socioeconomic burden, like schizophrenia. Distance correlation is an…

Biomedical entity linking and event extraction are two crucial tasks to support text understanding and retrieval in the biomedical domain. These two tasks intrinsically benefit each other: entity linking disambiguates the biomedical…

Computation and Language · Computer Science 2023-05-25 Xiaochu Li , Minqian Liu , Zhiyang Xu , Lifu Huang

Modern electronic health records (EHRs) provide data to answer clinically meaningful questions. The growing data in EHRs makes healthcare ripe for the use of machine learning. However, learning in a clinical setting presents unique…

Machine Learning · Computer Science 2019-12-09 Marzyeh Ghassemi , Tristan Naumann , Peter Schulam , Andrew L. Beam , Irene Y. Chen , Rajesh Ranganath

Biomedical entity linking aims to map biomedical mentions, such as diseases and drugs, to standard entities in a given knowledge base. The specific challenge in this context is that the same biomedical entity can have a wide range of names,…

Computation and Language · Computer Science 2021-05-25 Lihu Chen , Gaël Varoquaux , Fabian M. Suchanek

Discovery gene-disease links is important in biology and medicine areas, enabling disease identification and drug repurposing. Machine learning approaches accelerate this process by leveraging biological knowledge represented in ontologies…

Machine Learning · Computer Science 2025-04-14 Catarina Canastra , Cátia Pesquita

Constructing large-scaled medical knowledge graphs can significantly boost healthcare applications for medical surveillance, bring much attention from recent research. An essential step in constructing large-scale MKG is extracting…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Jialun Wu , Yang Liu , Zeyu Gao , Tieliang Gong , Chunbao Wang , Chen Li

This article presents our steps to integrate complex and partly unstructured medical data into a clinical research database with subsequent decision support. Our main application is an integrated faceted search tool, accompanied by the…

Human-Computer Interaction · Computer Science 2018-10-31 Daniel Sonntag , Hans-Jürgen Profitlich

Background : Knowledge is evolving over time, often as a result of new discoveries or changes in the adopted methods of reasoning. Also, new facts or evidence may become available, leading to new understandings of complex phenomena. This is…

Computation and Language · Computer Science 2023-04-24 Ayoub Harnoune , Maryem Rhanoui , Mounia Mikram , Siham Yousfi , Zineb Elkaimbillah , Bouchra El Asri

Missing data arise in most applied settings and are ubiquitous in electronic health records (EHR). When data are missing not at random (MNAR) with respect to measured covariates, sensitivity analyses are often considered. These post-hoc…

Methodology · Statistics 2023-07-11 Alexander W. Levis , Rajarshi Mukherjee , Rui Wang , Heidi Fischer , Sebastien Haneuse

PURPOSE: We propose a fully unsupervised method to learn latent disease networks directly from unstructured biomedical text corpora. This method addresses current challenges in unsupervised knowledge extraction, such as the detection of…

Digital Libraries · Computer Science 2019-12-18 Robert O'Shea

To comprehend the multipartite organization of large-scale biological and social systems, we introduce a new information theoretic approach that reveals community structure in weighted and directed networks. The method decomposes a network…

Physics and Society · Physics 2008-02-13 M. Rosvall , C. T. Bergstrom

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Physical activity is crucial for human health. With the increasing availability of large-scale mobile health data, strong associations have been found between physical activity and various diseases. However, accurately capturing this…

Methodology · Statistics 2026-01-19 Xiaojing Sun , Bingxin Zhao , Fei Xue
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