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Diffusion MRI (dMRI) streamline tractography, the gold standard for in vivo estimation of brain white matter (WM) pathways, has long been considered indicative of macroscopic relationships with WM microstructure. However, recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Tian Yu , Yunhe Li , Michael E. Kim , Chenyu Gao , Qi Yang , Leon Y. Cai , Susane M. Resnick , Lori L. Beason-Held , Daniel C. Moyer , Kurt G. Schilling , Bennett A. Landman

Purpose: Diffusion weighted MRI (dMRI) and its models of neural structure provide insight into human brain organization and variations in white matter. A recent study by McMaster, et al. showed that complex graph measures of the connectome,…

Diffusion tractography is routinely used to study white matter architecture and brain connectivity in vivo. A key step for successful tractography of neuronal tracts is the correct identification of tract directions in each voxel. Here we…

Traumatic brain injury (TBI) disrupts thalamocortical connectivity, contributing to cognitive impairment and post-traumatic epilepsy (PTE). This study presents a novel tractography-based framework that leverages diffusion maps to capture…

Quantitative Methods · Quantitative Biology 2025-10-21 Akul Sharma , Anand A. Joshi , Richard M. Leahy

Heterogeneous dynamics commonly emerges in anomalous diffusion with intermittent transitions of diffusion states but proves challenging to identify using conventional statistical methods. To effectively capture these transient changes of…

Biological Physics · Physics 2024-01-24 Xiang Qu , Yi Hu , Wenjie Cai , Yang Xu , Hu Ke , Guolong Zhu , Zihan Huang

Orthodontic treatment hinges on tooth alignment, which significantly affects occlusal function, facial aesthetics, and patients' quality of life. Current deep learning approaches predominantly concentrate on predicting transformation…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Yunbi Liu , Enqi Tang , Shiyu Li , Lei Ma , Juncheng Li , Shu Lou , Yongchu Pan , Qingshan Liu

We propose two strategies to improve the quality of tractography results computed from diffusion weighted magnetic resonance imaging (DW-MRI) data. Both methods are based on the same PDE framework, defined in the coupled space of positions…

Computer Vision and Pattern Recognition · Computer Science 2017-02-08 J. M. Portegies , R. H. J. Fick , G. R. Sanguinetti , S. P. L. Meesters , G. Girard , R. Duits

Purpose: In diffusion MRI (dMRI), the volumetric and bundle analyses of whole-brain tissue microstructure and connectivity can be severely impeded by an incomplete field-of-view (FOV). This work aims to develop a method for imputing the…

Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific…

Quantitative Methods · Quantitative Biology 2019-06-21 Samuel St-Jean , Maxime Chamberland , Max A. Viergever , Alexander Leemans

While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Jakob Wasserthal , Peter F. Neher , Klaus H. Maier-Hein

Optical diffraction tomography (ODT) is a tomographic technique that can be used to measure the three-dimensional (3D) refractive index distribution within living cells without the requirement of any marker. In principle, ODT can be…

Quantitative Methods · Quantitative Biology 2018-01-03 Paul Müller , Mirjam Schürmann , Chii J. Chan , Jochen Guck

We present a novel method for estimation of the fiber orientation distribution (FOD) function based on diffusion-weighted Magnetic Resonance Imaging (D-MRI) data. We formulate the problem of FOD estimation as a regression problem through…

Applications · Statistics 2016-12-23 Hao Yan , Owen Carmichael , Debashis Paul , Jie Peng

Diffusion MRI tractography is an advanced imaging technique for quantitative mapping of the brain's structural connectivity. Whole brain tractography (WBT) data contains over hundreds of thousands of individual fiber streamlines (estimated…

Image and Video Processing · Electrical Eng. & Systems 2022-07-12 Fan Zhang , Tengfei Xue , Weidong Cai , Yogesh Rathi , Carl-Fredrik Westin , Lauren J O'Donnell

Diffusion tensor imaging (DTI) is a popular magnetic resonance imaging technique used to characterize microstructural changes in the brain. DTI studies quantify the diffusion of water molecules in a voxel using an estimated 3x3 symmetric…

Methodology · Statistics 2021-03-30 Zhou Lan , Brian J. Reich , Dipankar Bandyopadhyay

Background: Diffusion tensor imaging (DTI) has been used to characterize forearm muscle architecture. Since only uniform sampling is performed for seed points rather than fiber tracts, the tracts may be unevenly distributed in the muscle…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Yang Li , Shihan Ma , Jiamin Zhao , Qing Li , Xinjun Sheng

While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to…

Computer Vision and Pattern Recognition · Computer Science 2019-09-26 Jakob Wasserthal , Peter Neher , Dusan Hirjak , Klaus H. Maier-Hein

Diffusion magnetic resonance imaging (dMRI) is an emerging medical technique used for describing water diffusion in an organic tissue. Typically, rank-2 tensors quantify this diffusion. From this quantification, it is possible to calculate…

Computer Vision and Pattern Recognition · Computer Science 2016-06-28 Hernan Dario Vargas Cardona , Mauricio A. Alvarez , Alvaro A. Orozco

Deep learning has shown great potential in accelerating diffusion tensor imaging (DTI). Nevertheless, existing methods tend to suffer from Rician noise and detail loss in reconstructing the DTI-derived parametric maps especially when…

Computer Vision and Pattern Recognition · Computer Science 2024-01-04 Wenxin Fan , Jian Cheng , Cheng Li , Xinrui Ma , Jing Yang , Juan Zou , Ruoyou Wu , Qiegen Liu , Shanshan Wang

Anomaly detection in complex, high-dimensional data, such as UAV sensor readings, is essential for operational safety but challenging for existing methods due to their limited sensitivity, scalability, and inability to capture intricate…

Machine Learning · Computer Science 2025-10-28 Mingze Gong , Juan Du , Jianbang You

Tractography traces the peak directions extracted from fiber orientation distribution (FOD) suffering from ambiguous spatial correspondences between diffusion directions and fiber geometry, which is prone to producing erroneous tracks while…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Yuanjing Feng , Lei Xie , Jingqiang Wang , Qiyuan Tian , Jianzhong He , Qingrun Zeng , Fei Gao