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We propose a statistical model of a large random network with high connectivity in order to describe the behavior of {\it E.\,coli} cells after exposure to acute stress. The building blocks of this network are feedback cycles typical of the…

Disordered Systems and Neural Networks · Physics 2022-02-22 S. Reich , S. Maoz , Y. Kaplan , H. Rappeport , N. Q. Balaban , O. Agam

A variety of physical, social and biological systems generate complex fluctuations with correlations across multiple time scales. In physiologic systems, these long-range correlations are altered with disease and aging. Such correlated…

Other Quantitative Biology · Quantitative Biology 2009-11-10 Luis A. N. Amaral , Albert Diaz-Guilera , Andre A. Moreira , Ary L. Goldberger , Lewis A. Lipsitz

We characterize different cell states, related to cancer and ageing phenotypes, by a measure of entropy of network ensembles, integrating gene expression values and protein interaction networks. The entropy measure estimates the parameter…

Molecular Networks · Quantitative Biology 2013-05-24 G. Menichetti , G. Bianconi , E. Giampieri , G. Castellani , D. Remondini

Cortical neurons are characterized by irregular firing and a broad distribution of rates. The balanced state model explains these observations with a cancellation of mean excitatory and inhibitory currents, which makes fluctuations drive…

Neurons and Cognition · Quantitative Biology 2020-10-15 Alessandro Sanzeni , Mark H Histed , Nicolas Brunel

We consider an excitatory random network of leaky integrate-and-fire pulse coupled neurons. The neurons are connected as in a directed Erd\"os-Renyi graph with average connectivity $<k>$ scaling as a power law with the number of neurons in…

Disordered Systems and Neural Networks · Physics 2012-08-28 Lorenzo Tattini , Simona Olmi , Alessandro Torcini

The protein p53 has a well established role in protecting genomic integrity in human cells. When DNA is damaged p53 induces the cell cycle arrest to prevent the transmission of the damage to cell progeny, triggers the production of proteins…

Molecular Networks · Quantitative Biology 2012-11-22 Lídice Cruz-Rodríguez , Nuris Figueroa-Morales , Roberto Mulet

Network theory is rapidly changing our understanding of complex systems, but the relevance of topological features for the dynamic behavior of metabolic networks, food webs, production systems, information networks, or cascade failures of…

Disordered Systems and Neural Networks · Physics 2007-05-23 Dirk Helbing , Ulrich Witt , Stefan Laemmer , Thomas Brenner

Both natural and engineered supply networks exhibit universal structural patterns, such as the formation of loops, yet the principles governing optimal structures remain unclear. These patterns can be interpreted as solutions of…

Adaptation and Self-Organizing Systems · Physics 2026-04-21 Aarathi Parameswaran , Andrea Benigni , Dirk Witthaut , Iva Bačić

In a manner similar to the molecular chaos that underlies the stable thermodynamics of gases, neuronal system may exhibit microscopic instability in individual neuronal dynamics while a macroscopic order of the entire population possibly…

Neurons and Cognition · Quantitative Biology 2015-06-23 Yuzuru Yamanaka , Shun-ichi Amari , Shigeru Shinomoto

We consider the multitasking associative network in the low-storage limit and we study its phase diagram with respect to the noise level $T$ and the degree $d$ of dilution in pattern entries. We find that the system is characterized by a…

Disordered Systems and Neural Networks · Physics 2013-04-17 Elena Agliari , Adriano Barra , Andrea Galluzzi , Marco Isopi

Random networks of symmetrically coupled, excitable elements can self-organize into coherently oscillating states if the networks contain loops (indeed loops are abundant in random networks) and if the initial conditions are sufficiently…

Disordered Systems and Neural Networks · Physics 2015-05-19 Patrick McGraw , Michael Menzinger

We demonstrate deterministic extensive chaos in the dynamics of large sparse networks of theta neurons in the balanced state. The analysis is based on numerically exact calculations of the full spectrum of Lyapunov exponents, the entropy…

Disordered Systems and Neural Networks · Physics 2011-01-14 Michael Monteforte , Fred Wolf

For a power system operating in the vicinity of the power transfer limit of its transmission system, effect of stochastic fluctuations of power loads can become critical as a sufficiently strong such fluctuation may activate voltage…

Physics and Society · Physics 2012-12-07 Dmitry Podolsky , Konstantin Turitsyn

We analyze transport on a graph with multiple constraints and where the weight of the edges connecting the nodes is a dynamical variable. The network dynamics results from the interplay between a nonlinear function of the flow, dissipation,…

Statistical Mechanics · Physics 2023-11-28 Frederic Folz , Kurt Mehlhorn , Giovanna Morigi

The dynamics of an extremely diluted neural network with high order synapses acting as corrections to the Hopfield model is investigated. As in the fully connected case, the high order terms may strongly improve the storage capacity of the…

Condensed Matter · Physics 2009-10-22 N. Lemke , J. J. Arenzon , F. A. Tamarit

We present a simple Markov model of spiking neural dynamics that can be analytically solved to characterize the stochastic dynamics of a finite-size spiking neural network. We give closed-form estimates for the equilibrium distribution,…

Neurons and Cognition · Quantitative Biology 2007-05-23 H. Soula , C. C. Chow

We examine the effect of structural disorder and dynamical lattice fluctuation on charge migration dynamics starting from a birth of local exciton in a quantum network of molecular aggregates by using model Hamiltonians having complicate…

Chemical Physics · Physics 2020-04-01 Takehiro Yonehara

Complex network states are characterized by the interplay between system's structure and dynamics. One way to represent such states is by means of network density matrices, whose von Neumann entropy characterizes the number of distinct…

Physics and Society · Physics 2022-12-06 Arsham Ghavasieh , Manlio De Domenico

Strong inhibitory input to neurons, which occurs in balanced states of neural networks, increases synaptic current fluctuations. This has led to the assumption that inhibition contributes to the high spike-firing irregularity observed in…

Neurons and Cognition · Quantitative Biology 2021-02-19 Tomas Barta , Lubomir Kostal

A dynamical system approaching the first-order transition can exhibit a specific type of critical behavior known as self-organized bistability (SOB). It lies in the fact that the system can permanently switch between the coexisting states…

Adaptation and Self-Organizing Systems · Physics 2022-11-14 Nikita Frolov , Alexander Hramov