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Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…
Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…
The accurate quantification of left ventricular (LV) deformation/strain shows significant promise for quantitatively assessing cardiac function for use in diagnosis and therapy planning (Jasaityte et al., 2013). However, accurate estimation…
Mechanical function of the heart during open-chest cardiac surgery is exclusively monitored by echocardiographic techniques. However, little is known about local kinematics, particularly for the reperfused regions after ischemic events. We…
Analysing the haemodynamics of flow in carotid artery disease serves as a means to better understand the development and progression of associated complex diseases. Carotid artery disease can predispose people to major adverse…
Frequently, transient changes in physiological signals, such as ECG morphology, precede or follow a rate change. Current methods for visualizing morphology allow only the tracking of preselected changes, severely limiting analytical…
Cardiac motion tracking from echocardiography can be used to estimate and quantify myocardial motion within a cardiac cycle. It is a cost-efficient and effective approach for assessing myocardial function. However, ultrasound imaging has…
We propose a number of variational regularisation methods for the estimation and decomposition of motion fields on the $2$-sphere. While motion estimation is based on the optical flow equation, the presented decomposition models are…
During the upstroke of a normal eye blink, the upper lid moves and paints a thin tear film over the exposed corneal and conjunctival surfaces. This thin tear film may be modeled by a nonlinear fourth-order PDE derived from lubrication…
Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been linked to the onset and progression of cardiovascular…
We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…
A clinically actionable Cardiac Digital Twin (CDT) should reconstruct individualised cardiac anatomy and physiology, update its internal state from multimodal signals, and enable a broad range of downstream simulations beyond isolated…
Accurate 3D aortic construction is crucial for clinical diagnosis, preoperative planning, and computational fluid dynamics (CFD) simulations, as it enables the estimation of critical hemodynamic parameters such as blood flow velocity,…
Objective evaluation of new and improved methods for PET imaging requires access to images with ground truth, as can be obtained through simulation studies. However, for these studies to be clinically relevant, it is important that the…
Computational fluid dynamics (CFD) models of blood flow in the left ventricle (LV) and aorta are important tools for analyzing the mechanistic links between myocardial deformation and flow patterns. Typically, the use of image-based…
Background: Coronary artery bypass grafting (CABG) planning requires advanced spatial visualization and consideration of coronary artery depth, calcification, and pericardial adhesions. Objective: To develop and evaluate a dynamic…
Electroanatomic mapping as routinely acquired in ablation therapy of ventricular tachycardia is the gold standard method to identify the arrhythmogenic substrate. To reduce the acquisition time and still provide maps with high spatial…
We show that the recoils of the body caused by cardiac motion and blood circulation provide a noninvasive method capable to display the motions of the heart muscle and the propagation of the pulse wave along aorta and its branches. The…
We use analytic bootstrap techniques for a CFT with an interface or a boundary. Exploiting the analytic structure of the bulk and boundary conformal blocks we extract the CFT data. We further constrain the CFT data by applying the equation…
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…