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Despite the significant advances in identifying the driver nodes and energy requiring in network control, a framework that incorporates more complicated dynamics remains challenging. Here, we consider the conformity behavior into network…

Physics and Society · Physics 2022-01-26 Zu-Yu Qian , Cheng Yuan , Jie Zhou , Shi-Ming Chen , Sen Nie

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

Molecular Networks · Quantitative Biology 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

Estimating dependence relationships between variables is a crucial issue in many applied domains, such as medicine, social sciences and psychology. When several variables are entertained, these can be organized into a network which encodes…

Methodology · Statistics 2025-01-01 Federico Castelletti

Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory…

Molecular Networks · Quantitative Biology 2007-05-23 M. Cosentino Lagomarsino , P. Jona , B. Bassetti

In communication networks structure and dynamics are tightly coupled. The structure controls the flow of information and is itself shaped by the dynamical process of information exchanged between nodes. In order to reconcile structure and…

Physics and Society · Physics 2013-04-08 Jan O. Haerter , Bjorn Jamtveit , Joachim Mathiesen

In this paper, controllability of undirected networked systems with {diffusively coupled subsystems} is considered, where each subsystem is of {identically {\emph{fixed}}} general high-order single-input-multi-output dynamics. The…

Systems and Control · Electrical Eng. & Systems 2020-04-21 Yuan Zhang , Yuanqing Xia , Han Gao , Guangchen Zhang

This paper (parts I and II) provides an expository introduction to monotone and near-monotone dynamical systems associated to biochemical networks, those whose graphs are consistent or near-consistent. Many conclusions can be drawn from…

Molecular Networks · Quantitative Biology 2007-05-23 Eduardo D. Sontag

Robust control theory has been successfully applied to numerous real-world problems using a small set of devices called {\it controllers}. However, the real systems represented by networks contain unreliable components and modern robust…

Physics and Society · Physics 2015-06-23 Jose C. Nacher , Tatsuya Akutsu

Critical points separate distinct dynamical regimes of complex systems, often delimiting functional or macroscopic phases in which the system operates. However, the long-term prediction of critical regimes and behaviors is challenging given…

Physics and Society · Physics 2025-04-15 Xiangrong Wang , Dan Lu , Zongze Wu , Weina Xu , Hongru Hou , Yanqing Hu , Yamir Moreno

The relation between network structure and dynamics is determinant for the behavior of complex systems in numerous domains. An important long-standing problem concerns the properties of the networks that optimize the dynamics with respect…

Adaptation and Self-Organizing Systems · Physics 2017-12-07 Takashi Nishikawa , Jie Sun , Adilson E. Motter

In this paper we consider complex dynamical networks modeled by means of state space systems running in discrete time. We assume that the dependency structure of the variables within the (nonlinear) network equations is known and use…

Optimization and Control · Mathematics 2017-03-27 Jacob van der Woude

Network structure strongly constrains the range of dynamic behaviors available to a complex system. These system dynamics can be classified based on their response to perturbations over time into two distinct regimes, ordered or chaotic,…

Disordered Systems and Neural Networks · Physics 2009-11-13 Matti Nykter , Nathan D. Price , Antti Larjo , Tommi Aho , Stuart A. Kauffman , Olli Yli-Harja , Ilya Shmulevich

This paper focuses on proposing a general control framework for large-scale Boolean networks (\texttt{BNs}). Only by the network structure, the concept of structural controllability for \texttt{BNs} is formalized. A necessary and sufficient…

Systems and Control · Electrical Eng. & Systems 2021-05-27 Shiyong Zhu , Jianquan Lu , Shun-ichi Azuma , Wei Xing Zheng

A recent article by Weidner et al. [2021] presents a method to extract graph properties that are predictive of the dynamical behavior of multivariate, discrete models of biochemical regulation. In other words, a method that uses only…

Quantitative Methods · Quantitative Biology 2021-10-22 Luis M. Rocha

A large variety of dynamical systems, such as chemical and biomolecular systems, can be seen as networks of nonlinear entities. Prediction, control, and identification of such nonlinear networks require knowledge of the state of the system.…

Optimization and Control · Mathematics 2018-06-27 Aleksandar Haber , Ferenc Molnar , Adilson E. Motter

There is increasing interest in developing the theoretical foundations of networked control systems that illuminate how brain networks function so as to enable sensory perception, control of movement, memory and all the operations that are…

Systems and Control · Electrical Eng. & Systems 2025-06-03 Zexin Sun , John Baillieul

This paper proposes a new method to reverse engineer gene regulatory networks from experimental data. The modeling framework used is time-discrete deterministic dynamical systems, with a finite set of states for each of the variables. The…

Quantitative Methods · Quantitative Biology 2007-05-23 Reinhard Laubenbacher , Brandilyn Stigler

Mathematical models are fundamental building blocks in the design of dynamical control systems. As control systems are becoming increasingly complex and networked, approaches for obtaining such models based on first principles reach their…

Machine Learning · Computer Science 2022-07-19 Dominik Baumann , Friedrich Solowjow , Karl H. Johansson , Sebastian Trimpe

A standard technique for understanding underlying dependency structures among a set of variables posits a shared conditional probability distribution for the variables measured on individuals within a group. This approach is often referred…

Machine Learning · Statistics 2014-05-13 Elham Azizi , James E. Galagan , Edoardo M. Airoldi

Boolean networks have been successfully used in modelling gene regulatory networks. In this paper we propose a reduction method that reduces the complexity of a Boolean network but keeps dynamical properties and topological features and…

Quantitative Methods · Quantitative Biology 2009-07-06 Alan Veliz-Cuba