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One of the grand challenges of cell biology is inferring the gene regulatory network (GRN) which describes interactions between genes and their products that control gene expression and cellular function. We can treat this as a causal…

Machine Learning · Computer Science 2023-12-27 Lazar Atanackovic , Alexander Tong , Bo Wang , Leo J. Lee , Yoshua Bengio , Jason Hartford

Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

The era of data deluge has sparked the interest in graph-based learning methods in a number of disciplines such as sociology, biology, neuroscience, or engineering. In this paper, we introduce a graph recurrent neural network (GRNN) for…

Machine Learning · Computer Science 2019-02-19 Vassilis N. Ioannidis , Antonio G. Marques , Georgios B. Giannakis

Countless learning tasks require dealing with sequential data. Image captioning, speech synthesis, and music generation all require that a model produce outputs that are sequences. In other domains, such as time series prediction, video…

Machine Learning · Computer Science 2015-10-20 Zachary C. Lipton , John Berkowitz , Charles Elkan

The potential of synthetic biology techniques for designing complex cellular circuits able to solve complicated computations opens a whole domain of exploration, beyond experiments and theory. Such cellular circuits could be used to carry…

Neurons and Cognition · Quantitative Biology 2013-10-21 Luís F. Seoane , Ricard V. Solé

Gene regulatory relationships can be abstracted as a gene regulatory network (GRN), which plays a key role in characterizing complex cellular processes and pathways. Recently, graph neural networks (GNNs), as a class of deep learning…

Molecular Networks · Quantitative Biology 2023-11-07 Hui Zhang , Xuexin An , Qiang He , Yudong Yao , Yudong Zhang , Feng-Lei Fan , Yueyang Teng

As a surrogate for computationally intensive meso-scale simulation of woven composites, this article presents Recurrent Neural Network (RNN) models. Leveraging the power of transfer learning, the initialization challenges and sparse data…

Materials Science · Physics 2024-07-08 Ehsan Ghane , Martin Fagerström , Mohsen Mirkhalaf

Artificial neurons built on synthetic gene networks have potential applications ranging from complex cellular decision-making to bioreactor regulation. Furthermore, due to the high information throughput of natural systems, it provides an…

Neural and Evolutionary Computing · Computer Science 2020-01-31 Sihao Huang

This article introduces Random Error Sampling-based Neuroevolution (RESN), a novel automatic method to optimize recurrent neural network architectures. RESN combines an evolutionary algorithm with a training-free evaluation approach. The…

Neural and Evolutionary Computing · Computer Science 2021-06-30 Andrés Camero , Jamal Toutouh , Enrique Alba

Inferring gene regulatory networks (GRNs) from single-cell RNA sequencing (scRNA-seq) data is a complex challenge that requires capturing the intricate relationships between genes and their regulatory interactions. In this study, we tackle…

Machine Learning · Computer Science 2024-07-26 Sindhura Kommu , Yizhi Wang , Yue Wang , Xuan Wang

Recurrent Neural Networks (RNNs) are among the most successful machine learning models for sequence modelling, but tend to suffer from an exponential increase in the number of parameters when dealing with large multidimensional data. To…

Machine Learning · Computer Science 2021-05-12 Yao Lei Xu , Danilo P. Mandic

We investigate the functioning of a classifying biological neural network from the perspective of statistical learning theory, modelled, in a simplified setting, as a continuous-time stochastic recurrent neural network (RNN) with identity…

Machine Learning · Statistics 2023-09-13 Wiebke Bartolomaeus , Youness Boutaib , Sandra Nestler , Holger Rauhut

Many important phenomena in biochemistry and biology exploit dynamical features such as multi-stability, oscillations, and chaos. Construction of novel chemical systems with such rich dynamics is a challenging problem central to the fields…

Molecular Networks · Quantitative Biology 2026-05-04 Alexander Dack , Benjamin Qureshi , Thomas E. Ouldridge , Tomislav Plesa

Real-time classification of Electromyography signals is the most challenging part of controlling a prosthetic hand. Achieving a high classification accuracy of EMG signals in a short delay time is still challenging. Recurrent neural…

Signal Processing · Electrical Eng. & Systems 2021-09-14 Reza Bagherian Azhiri , Mohammad Esmaeili , Mehrdad Nourani

Artificial neural network (NN) architecture design is a nontrivial and time-consuming task that often requires a high level of human expertise. Neural architecture search (NAS) serves to automate the design of NN architectures and has…

Neural and Evolutionary Computing · Computer Science 2024-09-10 Reinhard Booysen , Anna Sergeevna Bosman

In a recurrent setting, conventional approaches to neural architecture search find and fix a general model for all data samples and time steps. We propose a novel algorithm that can dynamically search for the structure of cells in a…

Machine Learning · Computer Science 2019-05-28 Xin Qian , Matthew Kennedy , Diego Klabjan

Current biocomputing approaches predominantly rely on engineered circuits with fixed logic, offering limited stability and reliability under diverse environmental conditions. Here, we use the GRNN framework introduced in our previous work…

Emerging Technologies · Computer Science 2025-09-29 Adrian Ratwatte , Samitha Somathilaka , Thanh Cao , Xu Li , Sasitharan Balasubramaniam

Bat algorithm (BA) is a recent optimization algorithm based on swarm intelligence and inspiration from the echolocation behavior of bats. One of the issues in the standard bat algorithm is the premature convergence that can occur due to the…

Neural and Evolutionary Computing · Computer Science 2018-05-16 Asma Chakri , Rabia Khelif , Mohamed Benouaret , Xin-She Yang

Background: Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide ``reverse engineering'' of such networks have been…

In this paper, we introduce a novel architecture to connecting adaptive learning and neural networks into an arbitrary machine's control system paradigm. Two consecutive Recurrent Neural Networks (RNNs) are used together to accurately model…

Machine Learning · Computer Science 2020-02-26 Srikanth Chandar , Harsha Sunder