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Chemical reaction networks (CRNs) provide a convenient language for modelling a broad variety of biological systems. These models are commonly studied with respect to the time series they generate in deterministic or stochastic simulations.…

Molecular Networks · Quantitative Biology 2019-07-11 Ozan Kahramanoğulları

Classical shortest-path methods rely on binary tropical semirings $(\min,+)$, whose dyadic structure limits them to pairwise cost interactions. However, many real-world systems, including logistics, supply chains, communication networks,…

Optimization and Control · Mathematics 2025-11-25 Chandrasekhar Gokavarapu , D. Madhusudhana Rao

Zero-one reaction networks are pivotal to cellular signaling, and establishing the equivalence of such networks represents a foundational computational challenge in the realm of chemical reaction network research. Herein, we propose a…

Molecular Networks · Quantitative Biology 2026-02-03 Yue Jiao , Xiaoxian Tang

We establish, for the first time, connections between feedforward neural networks with ReLU activation and tropical geometry --- we show that the family of such neural networks is equivalent to the family of tropical rational maps. Among…

Machine Learning · Computer Science 2018-05-21 Liwen Zhang , Gregory Naitzat , Lek-Heng Lim

Researchers working with mathematical models are often confronted by the related problems of parameter estimation, model validation, and model selection. These are all optimization problems, well-known to be challenging due to…

Quantitative Methods · Quantitative Biology 2016-04-04 Elizabeth Gross , Brent Davis , Kenneth L. Ho , Daniel J. Bates , Heather A. Harrington

We introduce a unifying and generalizing framework for complex and detailed balanced steady states in chemical reaction network theory. To this end, we generalize the graph commonly used to represent a reaction network. Specifically, we…

Dynamical Systems · Mathematics 2017-11-21 Elisenda Feliu , Daniele Cappelletti , Carsten Wiuf

The problem of achieving consensus in a network of connected systems arises in many science and engineering applications. In contrast to previous works, we focus on the system reactivity, i.e., the initial amplification of the norm of the…

Systems and Control · Electrical Eng. & Systems 2023-06-21 Amirhossein Nazerian , David Phillips , Hernan A. Makse , Francesco Sorrentino

Sparse polynomial systems with vertical coefficient dependencies arise naturally when describing the critical points of optimization problems and, when augmented with linear forms, the steady states of chemical reaction networks. Moreover,…

Algebraic Geometry · Mathematics 2026-05-11 Elisenda Feliu , Paul Alexander Helminck , Oskar Henriksson , Yue Ren , Benjamin Schröter , Máté L. Telek

We enumerate rational curves in toric surfaces passing through points and satisfying cross-ratio constraints using tropical and combinatorial methods. Our starting point is arXiv:1509.07453, where a tropical-algebraic correspondence theorem…

Algebraic Geometry · Mathematics 2018-05-02 Christoph Goldner

Chemical reaction networks are often used to model and understand biological processes such as cell signaling. Under the framework of chemical reaction network theory, a process is modeled with a directed graph and a choice of kinetics,…

Combinatorics · Mathematics 2020-12-07 Mark Curiel , Elizabeth Gross , Carlos Munoz

Perturbations are ubiquitous in metabolism. A central tool to understand and control their influence on metabolic networks is sensitivity analysis, which investigates how the network responds to external perturbations. We follow here a…

Molecular Networks · Quantitative Biology 2021-11-29 Nicola Vassena

Dynamical systems with polynomial right-hand sides are very important in various applications, e.g., in biochemistry and population dynamics. The mathematical study of these dynamical systems is challenging due to the possibility of…

Dynamical Systems · Mathematics 2026-01-16 Balázs Boros , Gheorghe Craciun , Oskar Henriksson , Jiaxin Jin , Diego Rojas La Luz

Metabolic networks, formed by a series of metabolic pathways, are made of intracellular and extracellular reactions that determine the biochemical properties of a cell, and by a set of interactions that guide and regulate the activity of…

Logic in Computer Science · Computer Science 2020-08-24 Jean-Marc Alliot , Marta Cialdea Mayer , Robert Demolombe , Martín Diéguez , Luis Fariñas del Cerro

In this paper we use the connections between tropical algebraic geometry and rigid analytic geometry in order to prove two main results. We use tropical methods to prove a theorem about the Newton polygon for convergent power series in…

Algebraic Geometry · Mathematics 2010-07-19 Joseph Rabinoff

Tropical algebraic geometry is the geometry of the tropical semiring $(\mathbb{R},\min,+)$. Its objects are polyhedral cell complexes which behave like complex algebraic varieties. We give an introduction to this theory, with an emphasis on…

Algebraic Geometry · Mathematics 2007-05-23 Jürgen Richter-Gebert , Bernd Sturmfels , Thorsten Theobald

We present a simple model of network dynamics that can be solved analytically for uniform networks. We obtain the dynamics of response of the system to perturbations. The analytical solution is an excellent approximation for random…

Cellular Automata and Lattice Gases · Physics 2009-11-11 M. A. M. de Aguiar , Irving R. Epstein , Yaneer Bar-Yam

We consider the question of when points in tropical affine space uniquely determine a tropical hypersurface. We introduce a notion of multiplicity of points so that this question may be meaningful even if some of the points coincide. We…

Algebraic Geometry · Mathematics 2016-09-26 Drew Johnson

We apply methods and techniques of tropical optimization to develop a new theoretical and computational framework for the implementation of the Analytic Hierarchy Process in multi-criteria problems of rating alternatives from pairwise…

Optimization and Control · Mathematics 2022-07-11 Nikolai Krivulin , Sergei Sergeev

Based on a description of project networks by max-plus algebra and poset, the adjacency of critical paths is presented using tropical geometry.

Optimization and Control · Mathematics 2012-03-01 Masanori Kobayashi , Shinsuke Odagiri

Graph transformation systems have the potential to be realistic models of chemistry, provided a comprehensive collection of reaction rules can be extracted from the body of chemical knowledge. A first key step for rule learning is the…

Discrete Mathematics · Computer Science 2016-04-22 Christoph Flamm , Daniel Merkle , Peter F. Stadler , Uffe Thorsen
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