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The homogeneous electron gas (HEG) is a key ingredient in the construction of most exchange-correlation functionals of density-functional theory. Often, the energy of the HEG is parameterized as a function of its spin density $n$, leading…
Spatial transcriptomics (ST) provides essential spatial context by mapping gene expression within tissue, enabling detailed study of cellular heterogeneity and tissue organization. However, aligning ST data with histology images poses…
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation…
We reveal a one-class homophily phenomenon, which is one prevalent property we find empirically in real-world graph anomaly detection (GAD) datasets, i.e., normal nodes tend to have strong connection/affinity with each other, while the…
Deploying generative machine learning techniques to generate novel chemical structures based on molecular fingerprint representation has been well established in molecular design. Typically, sequential learning (SL) schemes such as hidden…
Graph Anomaly Detection (GAD) aims to identify atypical graph entities, such as nodes, edges, or substructures, that deviate significantly from the majority. While existing text-rich approaches typically integrate structural context into…
Accurate gland segmentation in histopathology images is essential for cancer diagnosis and prognosis. However, significant variability in Hematoxylin and Eosin (H&E) staining and tissue morphology, combined with limited annotated data,…
Topological features based on persistent homology capture high-order structural information so as to augment graph neural network methods. However, computing extended persistent homology summaries remains slow for large and dense graphs and…
Genetic variants in cis-regulatory elements or trans-acting regulators commonly influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL) mapping has…
The location of the Scutum Red-Supergiant (RSG) clusters at the end of the Galactic Bar makes them an excellent probe of the Galaxy's secular evolution; while the clusters themselves are ideal testbeds in which to study the predictions of…
We investigate an algorithm named histogram transform ensembles (HTE) density estimator whose effectiveness is supported by both solid theoretical analysis and significant experimental performance. On the theoretical side, by decomposing…
The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological importance remains unappreciated. We show that this currently…
ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN)…
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by complex physiological processes. Previous research has predominantly focused on static cerebral interactions, often neglecting the brain's dynamic nature and…
Numerous biological approaches are available to characterise the mechanisms which govern the formation of human embryonic stem cell (hESC) colonies. To understand how the kinematics of single and pairs of hESCs impact colony formation, we…
Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of…
The cells and their spatial patterns in the tumor microenvironment (TME) play a key role in tumor evolution, and yet the latter remains an understudied topic in computational pathology. This study, to the best of our knowledge, is among the…
The recent HEGRA detection and spectrum of 1ES 1426+428 at TeV energies, once corrected for absorption using present estimates of the diffuse extragalactic IR background, suggest that the high energy peak of the Spectral Energy Distribution…
We construct renormalized holographic entanglement entropy (HEE) and subregion complexity (HSC) in the CV conjecture for asymptotically AdS$_4$ and AdS$_5$ geometries under relevant perturbations. Using the holographic renormalization…
Graphs are a standard framework for describing dynamical processes shaped by pairwise interactions among agents. But many systems involve interactions in groups of three or more agents. Here, we develop a method of "$\ell$-hyperedge…