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Spatial transcriptomics enables interrogating the molecular composition of tissue with ever-increasing resolution and sensitivity. However, costs, rapidly evolving technology, and lack of standards have constrained computational methods in…

We find evidence for accelerated evolution in compact group galaxies from the distribution in mid-infrared colorspace of 42 galaxies from 12 Hickson Compact Groups (HCGs) compared to the the distributions of several other samples including…

Cosmology and Nongalactic Astrophysics · Physics 2010-08-26 Lisa May Walker , Kelsey E. Johnson , Sarah C. Gallagher , John E. Hibbard , Ann E. Hornschemeier , Jane C. Charlton , Thomas H. Jarrett

Nb3Sn wires are now very close to their final optimization but despite its classical nature, detailed understanding of the role of Ta and Ti doping in the A15 is not fully understood. Long thought to be essentially equivalent in their…

Superconductivity · Physics 2016-01-27 C. Tarantini , Z. H. Sung , P. J. Lee , A. K. Ghosh , D. C. Larbalestier

We introduce a novel method to screen the promoters of a set of genes with shared biological function, against a precompiled library of motifs, and find those motifs which are statistically over-represented in the gene set. The gene sets…

Molecular Networks · Quantitative Biology 2008-11-11 Yuval Tabach , Ran Brosh , Yossi Buganim , Anat Reiner , Or Zuk , Assif Yitzhaky , Mark Koudritsky , Varda Rotter , Eytan Domany

Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of…

Molecular Networks · Quantitative Biology 2015-06-18 Daniel Jost

This paper presents HGEN that pioneers ensemble learning for heterogeneous graphs. We argue that the heterogeneity in node types, nodal features, and local neighborhood topology poses significant challenges for ensemble learning,…

Machine Learning · Computer Science 2026-02-05 Jiajun Shen , Yufei Jin , Yi He , Xingquan Zhu

Due to recent breakthroughs in state-of-the-art DNA sequencing technology, genomics data sets have become ubiquitous. The emergence of large-scale data sets provides great opportunities for better understanding of genomics, especially gene…

Genomics · Quantitative Biology 2020-12-18 Wei Cheng , Ghulam Murtaza , Aaron Wang

Adaptation of bacteria occurs predominantly via horizontal gene transfer (HGT). While it is widely recognized that horizontal acquisitions frequently encompass multiple genes, it is unclear what the size distribution of successfully…

Genomics · Quantitative Biology 2016-11-16 Tin Y Pang , Martin Lercher

Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure. We…

Biomolecules · Quantitative Biology 2011-08-09 Natalia A. Denesyuk , D. Thirumalai

Performance of deep learning segmentation models is significantly challenged in its transferability across different medical imaging domains, particularly when aiming to adapt these models to a target domain with insufficient annotated data…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Arnaud Judge , Thierry Judge , Nicolas Duchateau , Roman A. Sandler , Joseph Z. Sokol , Olivier Bernard , Pierre-Marc Jodoin

Sparse autoencoders (SAEs) have become central to mechanistic interpretability, decomposing transformer activations into monosemantic features. Yet existing analyses characterise features almost exclusively through top-activating token…

Artificial Intelligence · Computer Science 2026-05-08 Ruben Fernandez-Boullon , Pablo Magariños-Docampo , Javier Perez-Robles

The interplay of different emergent phenomena -- superconductivity (SC) and domain formation -- appearing on different spatial and energy scales are investigated using high-resolution scanning tunneling spectroscopy (STS) in the…

Semiconductor heterostructures have played a critical role as the enabler for new science and technology. The emergence of transition metal dichalcogenides (TMDs) as atomically thin semiconductors has opened new frontiers in semiconductor…

Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS). Most approaches currently used to store HTS data are either unable to…

Quantitative Methods · Quantitative Biology 2014-03-05 Fabien Campagne , Kevin C. Dorff , Nyasha Chambwe , James T. Robinson , Jill P. Mesirov , Thomas D. Wu

We report on the first local atomic structure study via the pair density function (PDF) analysis of neutron diffraction data and show a direct correlation of local coordinates to TC in the newly discovered superconducting FeSe1-xTex. The…

Two-dimensional iron-chalcogenide intercalates display a remarkable correlation of the interlayer spacing with the enhancement of the superconducting critical temperature ($T_c$). In this work, synchrotron x-ray absorption ($XAS$, at Fe and…

The growth of Sn-rich group-IV semiconductors at the nanoscale provides new paths for understanding the fundamental properties of metastable GeSn alloys. Here, we demonstrate the effect of the growth conditions on the morphology and…

Predicting genetic perturbations enables the identification of potentially crucial genes prior to wet-lab experiments, significantly improving overall experimental efficiency. Since genes are the foundation of cellular life, building gene…

Quantitative Methods · Quantitative Biology 2025-05-09 Changxi Chi , Jun Xia , Jingbo Zhou , Jiabei Cheng , Chang Yu , Stan Z. Li

We present a Spatially Embedded Evolutionary Algorithm where robot individuals exist in a physically simulated 2D environment, must navigate to encounter potential mates, and compete for survival under various spatially-aware selection…

Neural and Evolutionary Computing · Computer Science 2026-04-30 Victoria Peterson , Akshat Srivastava , Raghav Prabhakar

A single solid tumor, composed of nearly identical cells, exhibits heterogeneous dynamics. Cells dynamics in the core is glass-like whereas those in the periphery undergo diffusive or super-diffusive behavior. Quantification of…

Biological Physics · Physics 2020-11-24 Sumit Sinha , D. Thirumalai
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