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Recent AI research plots a promising future of automatic chemical reactions within the chemistry society. This study proposes Chemist-X, a comprehensive AI agent that automates the reaction condition optimization (RCO) task in chemical…

We propose a framework for online meta-optimization of parameters that govern optimization, called Amortized Proximal Optimization (APO). We first interpret various existing neural network optimizers as approximate stochastic proximal point…

Machine Learning · Computer Science 2022-03-02 Juhan Bae , Paul Vicol , Jeff Z. HaoChen , Roger Grosse

Multicriteria adjustable robust optimization (MARO) problems arise in a wide variety of practical settings, for example, in the design of a building's energy supply. However, no general approaches, neither for the characterization of…

Optimization and Control · Mathematics 2024-06-13 Elisabeth Halser , Elisabeth Finhold , Neele Leithäuser , Jan Schwientek , Katrin Teichert , Karl-Heinz Küfer

Adaptive control provides techniques for adjusting control parameters in real time to maintain system performance despite unknown or changing process parameters. These methods use real data to tune controllers and adjust plant models or…

Systems and Control · Electrical Eng. & Systems 2024-06-12 Ioan Doré Landau , Rogelio Lozano , Mohammed M Saad , Alireza Karimi

We present a differentiable formulation of abstract chemical reaction networks (CRNs) that can be trained to solve a variety of computational tasks. Chemical reaction networks are one of the most fundamental computational substrates used by…

Molecular Networks · Quantitative Biology 2023-02-07 Alexander Mordvintsev , Ettore Randazzo , Eyvind Niklasson

The probability distribution describing the state of a Stochastic Reaction Network evolves according to the Chemical Master Equation (CME). It is common to estimated its solution using Monte Carlo methods such as the Stochastic Simulation…

Quantitative Methods · Quantitative Biology 2015-06-18 Benjamin Hepp , Ankit Gupta , Mustafa Khammash

Atmospheric models demand a lot of computational power and solving the chemical processes is one of its most computationally intensive components. This work shows how to improve the computational performance of the Multiscale Online…

Modern computational chemistry has reached a stage at which massive exploration into chemical reaction space with unprecedented resolution with respect to the number of potentially relevant molecular structures has become possible. Various…

Chemical Physics · Physics 2020-04-27 Jan P. Unsleber , Markus Reiher

Stochastic and (distributionally) robust optimization problems often become computationally challenging as the number of scenarios or data points increases. Scenario reduction is therefore a key technique for improving tractability. We…

Optimization and Control · Mathematics 2026-03-10 Kevin-Martin Aigner , Sebastian Denzler , Frauke Liers , Sebastian Pokutta , Kartikey Sharma

Stochastic model predictive control has been a successful and robust control framework for many robotics tasks where the system dynamics model is slightly inaccurate or in the presence of environment disturbances. Despite the successes, it…

Robotics · Computer Science 2022-04-07 Rel Guzman , Rafael Oliveira , Fabio Ramos

Preference optimization is a critical post-training technique used to align large language models (LLMs) with human preferences, typically by fine-tuning on ranked response pairs. While methods like Direct Preference Optimization (DPO) have…

Computation and Language · Computer Science 2025-11-12 Rhitabrat Pokharel , Yufei Tao , Ameeta Agrawal

For simulation studies of (macro) molecular liquids it would be of significant interest to be able to adjust or increase the level of resolution within one region of space, while allowing for the free exchange of molecules between open…

Robotic systems are typically composed of various subsystems, such as localization and navigation, each encompassing numerous configurable components (e.g., selecting different planning algorithms). Once an algorithm has been selected for a…

Robotics · Computer Science 2025-02-26 Md Abir Hossen , Sonam Kharade , Jason M. O'Kane , Bradley Schmerl , David Garlan , Pooyan Jamshidi

The performance of an algorithm often critically depends on its parameter configuration. While a variety of automated algorithm configuration methods have been proposed to relieve users from the tedious and error-prone task of manually…

Artificial Intelligence · Computer Science 2022-05-30 Steven Adriaensen , André Biedenkapp , Gresa Shala , Noor Awad , Theresa Eimer , Marius Lindauer , Frank Hutter

Aligning large-scale vision-language models (VLMs) for complex reasoning via reinforcement learning is often hampered by the limitations of existing policy optimization algorithms, such as static training schedules and the rigid, uniform…

Artificial Intelligence · Computer Science 2025-10-02 Yunhao Wang , Ziting Li , Shuai Chen , Tao Liu , Chao Song , Junjie Jiang , Jian Zhu , Peng Gao , Bin Qin

Process control and optimization have been widely used to solve decision-making problems in chemical engineering applications. However, identifying and tuning the best solution algorithm is challenging and time-consuming. Machine learning…

Systems and Control · Electrical Eng. & Systems 2024-12-25 Ilias Mitrai , Prodromos Daoutidis

Current large language models (LLMs), even those explicitly trained for reasoning, often struggle with ambiguous content moderation cases due to misleading "decision shortcuts" embedded in context. Inspired by cognitive psychology insights…

Artificial Intelligence · Computer Science 2026-04-14 Bingzhe Wu , Haotian Lu , Yuchen Mou

Ant colony optimization (ACO) is a commonly used meta-heuristic to solve complex combinatorial optimization problems like traveling salesman problem (TSP), vehicle routing problem (VRP), etc. However, classical ACO algorithms provide better…

Emerging Technologies · Computer Science 2021-11-05 Mrityunjay Ghosh , Nivedita Dey , Debdeep Mitra , Amlan Chakrabarti

Accurate prediction of outcomes is crucial for clinical decision-making and personalized patient care. Supervised machine learning algorithms, which are commonly used for outcome prediction in the medical domain, optimize for predictive…

Machine Learning · Computer Science 2026-02-09 Nithya Bhasker , Fiona R. Kolbinger , Susu Hu , Gitta Kutyniok , Stefanie Speidel

Zero-order optimization has recently received significant attention for designing optimal trajectories and policies for robotic systems. However, most existing methods (e.g., MPPI, CEM, and CMA-ES) are local in nature, as they rely on…

Robotics · Computer Science 2026-02-09 Xudong Sun , Armand Jordana , Massimo Fornasier , Jalal Etesami , Majid Khadiv