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We consider a model for the dynamics of active cells interacting with their quiescent counterparts under the influence of acidity characterized by proton concentration. The active cells perform nonlinear diffusion and infer proliferation or…

Analysis of PDEs · Mathematics 2025-11-04 Maria Eckardt , Christina Surulescu

Although individual neurons and neural populations exhibit the phenomenon of representational drift, perceptual and behavioral outputs of many neural circuits can remain stable across time scales over which representational drift is…

This work studies distributed (probability) density estimation of large-scale systems. Such problems are motivated by many density-based distributed control tasks in which the real-time density of the swarm is used as feedback information,…

Systems and Control · Electrical Eng. & Systems 2021-06-03 Tongjia Zheng , Hai Lin

We investigate the asymptotic properties of deep Residual networks (ResNets) as the number of layers increases. We first show the existence of scaling regimes for trained weights markedly different from those implicitly assumed in the…

Machine Learning · Computer Science 2023-01-26 Rama Cont , Alain Rossier , Renyuan Xu

Simulation code for conventional supercomputers serves as a reference for neuromorphic computing systems. The present bottleneck of distributed large-scale spiking neuronal network simulations is the communication between compute nodes.…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-27 Melissa Lober , Markus Diesmann , Susanne Kunkel

Accurate models of robot dynamics are critical for safe and stable control and generalization to novel operational conditions. Hand-designed models, however, may be insufficiently accurate, even after careful parameter tuning. This…

Robotics · Computer Science 2021-11-29 Thai Duong , Nikolay Atanasov

We propose a new approach to learning the subgrid-scale model when simulating partial differential equations (PDEs) solved by the method of lines and their representation in chaotic ordinary differential equations, based on neural ordinary…

Numerical Analysis · Mathematics 2023-04-14 Shinhoo Kang , Emil M. Constantinescu

Neurons process sensory stimuli efficiently, showing sparse yet highly variable ensemble spiking activity involving structured higher-order interactions. Notably, while neural populations are mostly silent, they occasionally exhibit highly…

Neurons and Cognition · Quantitative Biology 2025-07-17 Ulises Rodríguez-Domínguez , Hideaki Shimazaki

Discovering a suitable neural network architecture for modeling complex dynamical systems poses a formidable challenge, often involving extensive trial and error and navigation through a high-dimensional hyper-parameter space. In this…

Machine Learning · Computer Science 2024-03-26 Chinmay Datar , Adwait Datar , Felix Dietrich , Wil Schilders

Modeling biological dynamical systems is challenging due to the interdependence of different system components, some of which are not fully understood. To fill existing gaps in our ability to mechanistically model physiological systems, we…

Both discrete and continuum models have been widely used to study rapid granular flow, discrete model is accurate but computationally expensive, whereas continuum model is computationally efficient but its accuracy is doubtful in many…

Fluid Dynamics · Physics 2015-12-24 Xizhong Chen , Junwu Wang , Jinghai Li

Complex biological processes involve collective behavior of entities (bacteria, cells, animals) over many length and time scales and can be described by discrete models that track individuals or by continuum models involving densities and…

Soft Condensed Matter · Physics 2023-11-16 F. Terragni , W. D. Martinson , M. Carretero , P. K. Maini , L. L. Bonilla

Accurate crowd simulation is crucial for public safety management, emergency evacuation planning, and intelligent transportation systems. However, existing methods, which typically model crowds as a collection of independent individual…

Machine Learning · Computer Science 2026-04-14 Zijin Liu , Xu Geng , Wenshuai Xu , Xiang Zhao , Yan Xia , You Song

Traditionally, calcium dynamics in neurons are modeled using partial differential equations (PDEs) and ordinary differential equations (ODEs). The PDE component focuses on reaction-diffusion processes, while the ODE component addresses…

Numerical Analysis · Mathematics 2024-07-23 Abel Gurung , Qingguang Guan

Purpose: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network (DNN) behavior during multi-parametric MRI (mp-MRI) based glioma segmentation as a method to enhance deep learning explainability.…

Quantitative Methods · Quantitative Biology 2022-03-25 Zhenyu Yang , Zongsheng Hu , Hangjie Ji , Kyle Lafata , Scott Floyd , Fang-Fang Yin , Chunhao Wang

The problem of synchronization in networks of neural mass model populations with discrete couplings is considered. The considered network is hybrid one, therefore Mikheev approach is applied to transform it to the network with time-varying…

Adaptation and Self-Organizing Systems · Physics 2023-05-04 Sergei Plotnikov

The brain produces rhythms in a variety of frequency bands. Some are likely by-products of neuronal processes; others are thought to be top-down. Produced entirely naturally, these rhythms have clearly recognizable beats, but they are very…

Dynamical Systems · Mathematics 2020-06-09 Benjamin Ambrosio , Lai-Sang Young

We present an account of neuroplasticity with respect to cell-internal processing pathways in relation to membrane and synaptic plasticity. We think traditional synapse-centric, weight-based models of memorization are not sufficient or…

Neurons and Cognition · Quantitative Biology 2026-04-27 Gabriele Scheler

A significant challenge in many fields of science and engineering is making sense of time-dependent measurement data by recovering governing equations in the form of differential equations. We focus on finding parsimonious ordinary…

Machine Learning · Computer Science 2024-10-04 Doris Voina , Steven Brunton , J. Nathan Kutz

Multiscale dynamical systems characterized by interacting fast and slow processes are ubiquitous across scientific domains, from climate dynamics to fluid mechanics. Accurate modeling of such systems requires capturing both the long-term…

Chaotic Dynamics · Physics 2025-11-07 Giulio Del Felice , Ludovico Theo Giorgini