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Motivation: A pan-genome graph represents a collection of genomes and encodes sequence variations between them. It is a powerful data structure for studying multiple similar genomes. Sequence-to-graph alignment is an essential step for the…

Genomics · Quantitative Biology 2022-06-29 Haowen Zhang , Shiqi Wu , Srinivas Aluru , Heng Li

Limits on power dissipation have pushed CPUs to grow in parallel processing capabilities rather than clock rate, leading to the rise of "manycore" or GPU-like processors. In order to achieve the best performance, applications must be able…

This article presents an automatic approach to quickly derive a good solution for hardware resource partition and task granularity for task-based parallel applications on heterogeneous many-core architectures. Our approach employs a…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-03-10 Peng Zhang , Jianbin Fang , Canqun Yang , Chun Huang , Tao Tang , Zheng Wang

Neural kernels have drastically increased performance on diverse and nonstandard data modalities but require significantly more compute, which previously limited their application to smaller datasets. In this work, we address this by…

Machine Learning · Statistics 2023-03-10 Ben Adlam , Jaehoon Lee , Shreyas Padhy , Zachary Nado , Jasper Snoek

Deoxyribonucleic acid (DNA) has shown great promise in enabling computational applications, most notably in the fields of DNA digital data storage and DNA computing. Information is encoded as DNA strands, which will naturally bind in…

Machine Learning · Computer Science 2021-10-22 David Buterez

Three approaches to implement genetic programming on GPU hardware are compilation, interpretation and direct generation of machine code. The compiled approach is known to have a prohibitive overhead compared to other two. This paper…

Neural and Evolutionary Computing · Computer Science 2017-05-23 Hakan Ayral , Songül Albayrak

Approximate Nearest Neighbor Search (ANNS) has become fundamental to modern deep learning applications, having gained particular prominence through its integration into recent generative models that work with increasingly complex datasets…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-28 Yuntao Gui , Peiqi Yin , Xiao Yan , Chaorui Zhang , Weixi Zhang , James Cheng

Assembling a gene from candidate exons is an important problem in computational biology. Among the most successful approaches to this problem is \emph{spliced alignment}, proposed by Gelfand et al., which scores different candidate exon…

Data Structures and Algorithms · Computer Science 2007-07-24 Alexander Tiskin

Today, one of the main challenges for high-performance computing systems is to improve their performance by keeping energy consumption at acceptable levels. In this context, a consolidated strategy consists of using accelerators such as…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-05-18 Manuel Costanzo , Enzo Rucci , Ulises Costi , Franco Chichizola , Marcelo Naiouf

The performance of biomolecular molecular dynamics simulations has steadily increased on modern high performance computing resources but acceleration of the analysis of the output trajectories has lagged behind so that analyzing simulations…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-03-31 Mahzad Khoshlessan , Ioannis Paraskevakos , Geoffrey C. Fox , Shantenu Jha , Oliver Beckstein

Upcoming many core processors are expected to employ a distributed memory architecture similar to currently available supercomputers, but parallel pattern mining algorithms amenable to the architecture are not comprehensively studied. We…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-10-28 Kazuki Yoshizoe , Aika Terada , Koji Tsuda

Similarity search finds application in specialized database systems handling complex data such as images or videos, which are typically represented by high-dimensional features and require specific indexing structures. This paper tackles…

Computer Vision and Pattern Recognition · Computer Science 2018-06-07 Jeff Johnson , Matthijs Douze , Hervé Jégou

In this work, a pattern recognition algorithm was developed to process and analyze electron emission micrographs. Various examples of dc and rf emission are given that demonstrate this algorithm applicability to determine emitters spatial…

Applied Physics · Physics 2020-12-08 Taha Y. Posos , Oksana Chubenko , Sergey V. Baryshev

To simulate long time and length scale processes involving DNA it is necessary to use a coarse-grained description. Here we provide an overview of different approaches to such coarse graining, focussing on those at the nucleotide level that…

In this paper, we study the parallelization of the dedispersion algorithm on many-core accelerators, including GPUs from AMD and NVIDIA, and the Intel Xeon Phi. An important contribution is the computational analysis of the algorithm, from…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-01-20 Alessio Sclocco , Henri E. Bal , Jason Hessels , Joeri van Leeuwen , Rob V. van Nieuwpoort

As AI chips incorporate numerous parallelized cores to scale deep learning (DL) computing, inter-core communication is enabled recently by employing high-bandwidth and low-latency interconnect links on the chip (e.g., Graphcore IPU). It…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-25 Yiqi Liu , Yuqi Xue , Yu Cheng , Lingxiao Ma , Ziming Miao , Jilong Xue , Jian Huang

Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Genome analysis has revolutionized fields such as personalized medicine and forensics. Modern sequencing machines generate vast amounts of fragmented strings of genome data called reads. The alignment of these reads into a complete DNA…

Hardware Architecture · Computer Science 2024-11-22 Rotem Ben-Hur , Orian Leitersdorf , Ronny Ronen , Lidor Goldshmidt , Idan Magram , Lior Kaplun , Leonid Yavitz , Shahar Kvatinsky

We give an overview of QPACE 2, which is a custom-designed supercomputer based on Intel Xeon Phi processors, developed in a collaboration of Regensburg University and Eurotech. We give some general recommendations for how to write…

Powerful yet complex deep neural networks (DNNs) have fueled a booming demand for efficient DNN solutions to bring DNN-powered intelligence into numerous applications. Jointly optimizing the networks and their accelerators are promising in…

Machine Learning · Computer Science 2025-01-07 Yongan Zhang , Yonggan Fu , Weiwen Jiang , Chaojian Li , Haoran You , Meng Li , Vikas Chandra , Yingyan Celine Lin