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In this paper, we study effects of permanent charges on ion flows through membrane channels via a quasi-one-dimensional classical Poisson-Nernst-Planck system. This system includes three ion species, two cations with different valences and…

Soft Condensed Matter · Physics 2023-12-07 Ning Sun , Weishi Liu

We discuss various models of ion transport through cell membrane channels. Recent experimental data shows that sizes of ion channels are compared to those of ions and that only few ions may be simultaneously in any single channel.…

Subcellular Processes · Quantitative Biology 2007-06-06 Jan Gomulkiewicz , Jacek Miekisz , Stanislaw Miekisz

Ion transport in biological and synthetic nanochannels is characterized by phenomena such as ion current fluctuations and rectification. Recently, it has been demonstrated that nanofabricated synthetic pores can mimic transport properties…

Classical Physics · Physics 2009-11-13 I. D. Kosińska , I. Goychuk , M. Kostur , G. Schmid , P. Hänggi

In ionic solutions, there are multi-species charged particles (ions) with different properties like mass, charge etc. Macroscopic continuum models like the Poisson-Nernst-Planck (PNP) systems have been extensively used to describe the…

Analysis of PDEs · Mathematics 2024-08-21 Hao Wu , Tai-Chia Lin , Chun Liu

We present an implicit statistical model for the steric effect on the potential of mean force (PMF) of a molecule diffusing through a flexible nanochannel of varying size. The average cross sectional area profile of the channel and the…

Soft Condensed Matter · Physics 2019-06-26 I. V. Bodrenko , S. Salis , S. Acosta-Gutierrez , M. Ceccarelli

Characterizing the local voltage distribution within nanophysiological domains, driven by ionic currents through membrane channels, is crucial for studying cellular activity in modern biophysics, yet it presents significant experimental and…

Soft Condensed Matter · Physics 2026-05-14 Frédéric Paquin-Lefebvre , Alejandro Barea Moreno , David Holcman

We present a finite volume scheme for modeling the diffusion of charged particles, specifically ions, in constrained geometries using a degenerate Poisson-Nernst-Planck system with size exclusion yielding cross-diffusion. Our method…

Numerical Analysis · Mathematics 2026-03-04 Clément Cancès , Maxime Herda , Annamaria Massimini

Ion channels are of major interest and form an area of intensive research in the fields of biophysics and medicine since they control many vital physiological functions. The aim of this work is on one hand to propose a fully stochastic and…

Biomolecules · Quantitative Biology 2016-01-11 Daniela Morale , Mattia Zanella , Vincenzo Capasso , Willi Jaeger

In this paper, based on geometric singular perturbation analysis of a quasi-one dimensional Poisson-Nernst-Planck model for ionic flows, we study the problem of zero current condition for ionic flows through membrane channels with a simple…

Dynamical Systems · Mathematics 2020-09-22 Hamid Mofidi , Weishi Liu

We have studied the dynamics of chloride and potassium ions in the interior of the OmpF porin under the influence of an external electric field. From the results of extensive all-atom molecular dynamics simulations of the system we computed…

Soft Condensed Matter · Physics 2015-05-20 Carles Calero , Jordi Faraudo , Marcel Aguilella-Arzo

Inferring dynamical models from data continues to be a significant challenge in computational biology, especially given the stochastic nature of many biological processes. We explore a common scenario in omics, where statistically…

Machine Learning · Computer Science 2025-07-31 Suryanarayana Maddu , Victor Chardès , Michael. J. Shelley

A Poisson-Fermi model is proposed for calculating activity coefficients of single ions in strong electrolyte solutions based on the experimental Born radii and hydration shells of ions in aqueous solutions. The steric effect of water…

Chemical Physics · Physics 2015-06-26 Jinn-Liang Liu , Bob Eisenberg

We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular ion concentration. The model combines a simplified Poisson-Nernst-Planck (PNP) model of ion transport through…

Biological Physics · Physics 2023-09-06 Linda Werneck , Mertcan Han , Erdost Yildiz , Marc-André Keip , Metin Sitti , Michael Ortiz

We present a general hydrodynamic theory of transport in the vicinity of superfluid-insulator transitions in two spatial dimensions described by "Lorentz"-invariant quantum critical points. We allow for a weak impurity scattering rate, a…

Strongly Correlated Electrons · Physics 2008-11-26 Sean A. Hartnoll , Pavel K. Kovtun , Markus Mueller , Subir Sachdev

Previous studies have highlighted significant advancements in multimodal fusion. Nevertheless, such methods often encounter challenges regarding the efficacy of feature extraction, data integrity, consistency of feature dimensions, and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Jiayu Xiong , Jing Wang , Hengjing Xiang , Jun Xue , Chen Xu , Zhouqiang Jiang

In this article we address the study of ion charge transport in the biological channels separating the intra and extracellular regions of a cell. The focus of the investigation is devoted to including thermal driving forces in the…

Numerical Analysis · Mathematics 2015-04-24 Riccardo Sacco , Fabio Manganini , Joseph W. Jerome

Electrochemical cells serve as a building block for producing and storing electrical energy from chemical reactions. The analysis of ion transport in these systems forms the foundation for understanding more complex electrochemical systems…

Chemical Physics · Physics 2026-02-05 Grace Origer , Ritu R. Raj , Nathan Jarvey , P. N. Romero Zavala , Wilson A. Smith , Ankur Gupta

A simple theory of ion permeation through a channel is presented, in which diffusion occurs according to Fick's law and drift according to Ohm's law, in the electric field determined by all the charges present. This theory accounts for…

Biomolecules · Quantitative Biology 2016-10-17 Bob Eisenberg

A system modeling the electrophoretic motion of a charged rigid macromolecule immersed in a incompressible ionized fluid is considered. The ionic concentration is governing by the Nernst-Planck equation coupled with the Poisson equation for…

Analysis of PDEs · Mathematics 2014-02-20 Luciano Bedin , Mark Thompson

Ion flow in charged nanopores is strongly influenced by the ratio of the Debye length to the pore radius. We investigate the asymptotic behaviour of solutions to the Poisson-Nernst-Planck (PNP) system in narrow pore like geometries and…

Analysis of PDEs · Mathematics 2019-04-10 B. Matejczyk , J. -F. Pietschmann , G. Richardson , M. -T. Wolfram