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Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation. Successful navigation relies on…

Molecular Networks · Quantitative Biology 2014-12-02 Yann S. Dufour , Xiongfei Fu , Luis Hernandez-Nunez , Thierry Emonet

Genes and proteins regulate cellular functions through complex circuits of biochemical reactions. Fluctuations in the components of these regulatory networks result in noise that invariably corrupts the signal, possibly compromising…

Molecular Networks · Quantitative Biology 2016-03-15 Michael Hinczewski , D. Thirumalai

Fluctuations in intracellular reactions (intrinsic noise) reduce the information transmitted from an extracellular input to a cellular response. However, recent studies have demonstrated that the decrease in the transmitted information with…

Molecular Networks · Quantitative Biology 2019-10-09 Takehiro Tottori , Masashi Fujii , Shinya Kuroda

With the growing efforts in isolating solid-state qubits from external decoherence sources, the material-inherent sources of noise start to play crucial role. One representative example is electron traps in the device material or substrate.…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 Y. M. Galperin , B. L. Altshuler , D. V. Shantsev

In a companion paper [1], we present a general approach to evaluate the impact of cognition in a downlink cellular system in which multiple relays assist the transmission of the base station. This approach is based on a novel theoretical…

Information Theory · Computer Science 2013-03-29 Stefano Riniy , Ernest Kurniawan , Levan Ghaghanidze , Andrea Goldsmith

Gaussian macroscopic fluctuation theory underpins the understanding of noise in a broad class of nonequilibrium systems. We derive exact fluctuation-response relations linking the power spectral density of stationary fluctuations to the…

Statistical Mechanics · Physics 2026-02-11 Timur Aslyamov , Krzysztof Ptaszyński , Massimiliano Esposito

We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations,…

Cell Behavior · Quantitative Biology 2009-11-13 A. J. McKane , J. D. Nagy , T. J. Newman , M. O. Stefanini

Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the…

Molecular Networks · Quantitative Biology 2012-03-28 Jost Neigenfind , Sergio Grimbs , Zoran Nikoloski

This paper discusses elements of a control theory of systems comprised of networks of simple agents that collectively achieve sensing and actuation goals despite having strictly limited capability when acting alone. The goal is to…

Systems and Control · Computer Science 2019-10-22 John Baillieul

Feedback loops in a dynamic network play an important role in determining the dynamics of that network. Through a computational study, in this paper we show that networks with fewer independent negative feedback loops tend to exhibit more…

Quantitative Methods · Quantitative Biology 2009-11-13 Eduardo Sontag , Alan Veliz-Cuba , Reinhard Laubenbacher , Abdul Salam Jarrah

The concept of a controlled flow of a dynamical system, especially when the controlling process feeds information back about the system, is of central importance in control engineering. In this paper we build on the ideas presented by…

Quantum Physics · Physics 2017-08-02 John E. Gough

In this study, we rederive the fluctuation theorems in presence of feedback, by assuming the known Jarzynski equality and detailed fluctuation theorems. We first reproduce the already known work theorems for a classical system, and then…

Statistical Mechanics · Physics 2015-05-30 Sourabh Lahiri , Shubhashis Rana , A. M. Jayannavar

We consider a three-node decode-and-forward (DF) half-duplex relaying system, where the source first harvests RF energy from the relay, and then uses this energy to transmit information to the destination via the relay. We assume that the…

Information Theory · Computer Science 2016-01-19 Zoran Hadzi-Velkov , Nikola Zlatanov , Trung Q. Duong , Robert Schober

We consider the optimal design of sequential transmission over broadcast channel with nested feedback. Nested feedback means that the channel output of the outer channel is also available at the decoder of the inner channel. We model the…

Information Theory · Computer Science 2010-04-08 Aditya Mahajan

Learning depends on changes in synaptic connections deep inside the brain. In multilayer networks, these changes are triggered by error signals fed back from the output, generally through a stepwise inversion of the feedforward processing…

Neurons and Cognition · Quantitative Biology 2021-01-05 William F. Podlaski , Christian K. Machens

It is now well established that the cell is a highly crowded environment. Yet, the effects of crowding on the dynamics of signaling pathways, gene regulation networks and metabolic networks are still largely unknown. Crowding can alter both…

Molecular Networks · Quantitative Biology 2013-11-19 Pieter Rein ten Wolde , Andrew Mugler

This paper reports relative performance of decode-and-forward (DF) and amplify-and-forward (AF) relaying in a multi-antenna cooperative cognitive radio network (CCRN) that supports device-to-device (D2D) communications using spectrum…

Information Theory · Computer Science 2020-07-20 Sutanu Ghosh , Tamaghna Acharya , Santi P. Maity

For most stochastic dynamical systems, variables which are tightly regulated tend to respond slowly to external changes. This idea is often discussed for applicable systems, within a linear response regime, through the Fluctuation…

General Physics · Physics 2017-11-15 Nash Rochman , Sean X. Sun

An incoherent feed-forward loop (IFFL) is a network motif known for its ability to accelerate responses and generate pulses. Though functions of IFFLs are well studied, most previous computational analysis of IFFLs used ordinary…

Molecular Networks · Quantitative Biology 2020-09-29 Junmin Wang , Calin Belta , Samuel A. Isaacson

Closed-loop or feedback control ratchets use information about the state of the system to operate with the aim of maximizing the performance of the system. In this paper we investigate the effects of a time delay in the feedback for a…

Statistical Mechanics · Physics 2007-12-13 M. Feito , F. J. Cao