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We describe a new family of coupling designs, extending the basic principle of stratified randomization to experiments with continuous, constrained multivariate, text/image and other irregular treatment spaces. Our approach is to first…

Econometrics · Economics 2026-04-14 Max Cytrynbaum , Fredrik Sävje

This paper considers the problem of inference in cluster randomized experiments when cluster sizes are non-ignorable. Here, by a cluster randomized experiment, we mean one in which treatment is assigned at the cluster level. By…

Econometrics · Economics 2024-04-11 Federico Bugni , Ivan Canay , Azeem Shaikh , Max Tabord-Meehan

Herd immunity is shaped not only by the infection capacity of a spreading epidemic or the contact structure of the hosting population, but also by how and under what circumstances individuals acquire immunity. Immunization strategies may…

Physics and Society · Physics 2026-02-20 Sámuel G. Balogh , Gergely Ódor , Márton Karsai

If we can lower the number of people needed to vaccinate for a community to be immune against contagious diseases, we can save resources and life. A key to reach such a lower threshold of immunization is to find and vaccinate people who,…

Populations and Evolution · Quantitative Biology 2012-10-10 Sungmin Lee , Luis E. C. Rocha , Fredrik Liljeros , Petter Holme

Estimating causal effects under interference is pertinent to many real-world settings. Recent work with low-order potential outcomes models uses a rollout design to obtain unbiased estimators that require no interference network…

Methodology · Statistics 2025-02-12 Mayleen Cortez-Rodriguez , Matthew Eichhorn , Christina Lee Yu

It has recently become established that the spread of infectious diseases between humans is affected not only by the pathogen itself but also by changes in behavior as the population becomes aware of the epidemic; for example, social…

Physics and Society · Physics 2013-10-09 Yilei Bu , Steve Gregory , Harriet L. Mills

Many social, technological and biological interactions involve network relationships whose outcome intimately depends on the structure of the network and on the strengths of the connections. Yet, although much information is now available…

Statistical Mechanics · Physics 2009-11-10 Guido Caldarelli , Fabrizio Coccetti , Paolo De Los Rios

To control infection spreading on networks, we investigate the effect of observer nodes that recognize infection in a neighboring node and make the rest of the neighbor nodes immune. We numerically show that random placement of observer…

Physics and Society · Physics 2014-07-15 Taro Takaguchi , Takehisa Hasegawa , Yuichi Yoshida

We extend the study of a model of competitive cluster growth in an active medium to a basis of networks; this is done by adding nonlocal connections with probability $p$ to sites on a regular lattice, thus enabling one to interpolate…

Statistical Mechanics · Physics 2010-12-10 N. Nirmal Thyagu , Anita Mehta

We study empirically the time evolution of scientific collaboration networks in physics and biology. In these networks, two scientists are considered connected if they have coauthored one or more papers together. We show that the…

Statistical Mechanics · Physics 2009-11-07 M. E. J. Newman

We introduce a dynamic model for complexity control (CC) between systems, represented by time series characterized by different temporal complexity measures, as indicated by their respective inverse power law (IPL) indices. Given the…

Adaptation and Self-Organizing Systems · Physics 2024-10-25 Korosh Mahmoodi , Scott E. Kerick , Piotr J. Franaszczuk , Paolo Grigolini , Bruce J. West

The power of any kind of network approach lies in the ability to simplify a complex system so that one can better understand its function as a whole. Sometimes it is beneficial, however, to include more information than in a simple graph of…

Physics and Society · Physics 2015-09-21 Petter Holme

Contact tracing has been extensively studied from different perspectives in recent years. However, there is no clear indication of why this intervention has proven effective in some epidemics (SARS) and mostly ineffective in some others…

Social and Information Networks · Computer Science 2021-03-01 Quyu Kong , Manuel Garcia-Herranz , Ivan Dotu , Manuel Cebrian

Network structure can affect when and how widely new ideas, products, and behaviors are adopted. In widely-used models of biological contagion, interventions that randomly rewire edges (on average making them "longer") accelerate spread.…

Social and Information Networks · Computer Science 2023-08-22 Dean Eckles , Elchanan Mossel , M. Amin Rahimian , Subhabrata Sen

Causal effect estimation in networked systems is central to data-driven decision making. In such settings, interventions on one unit can spill over to others, and in complex physical or social systems, the interaction pathways driving these…

Machine Learning · Statistics 2025-11-27 Sadegh Shirani , Mohsen Bayati

Randomized controlled trials are the gold standard for causal inference and play a pivotal role in modern evidence-based medicine. However, the sample sizes they use are often too limited to draw significant causal conclusions for subgroups…

Methodology · Statistics 2024-04-26 Xi Lin , Jens Magelund Tarp , Robin J. Evans

Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW-CRTs must account for time trends in the outcome…

Methodology · Statistics 2024-07-16 Lee Kennedy-Shaffer , Victor De Gruttola , Marc Lipsitch

Composite endpoints are increasingly used in clinical trials to capture treatment effects across multiple or hierarchically ordered outcomes. Although inference procedures based on win statistics, such as the win ratio, win odds, and net…

Methodology · Statistics 2025-10-28 Xi Fang , Zhiqiang Cao , Fan Li

In oncology the efficacy of novel therapeutics often differs across patient subgroups, and these variations are difficult to predict during the initial phases of the drug development process. The relation between the power of randomized…

Methodology · Statistics 2025-06-05 Boyu Ren , Federico Ferrari , Sandra Fortini , Steffen Ventz , Lorenzo Trippa

Clustering and dependence are common in trials. For example, in some cluster randomized trials (CRTs), pre-existing clusters are enrolled, randomized, and serve as the basis of intervention delivery. Such CRTs are "fully clustered":…

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