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In experiments on model membranes, a formation of large domains of different lipid composition is readily observed. However, no such phase separation is observed in the membranes of intact cells. Instead, a structure of small transient…

Soft Condensed Matter · Physics 2017-08-23 Timo Fischer , H. Jelger Risselada , Richard L. C. Vink

In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary. These models are used to simulate the deformation of membranes under the elastic…

Biological Physics · Physics 2007-05-23 Xiaoqiang Wang , Qiang Du

A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a…

Analysis of PDEs · Mathematics 2016-06-29 Charles M. Elliott , Carsten Gräser , Graham Hobbs , Ralf Kornhuber , Maren-Wanda Wolf

Phase separation of two phase separating solutes in a common solvent can result in mesoscale (micron-sized) droplets with complex topologies of the domains of each solute within each droplet. Such topologies have been observed in-vitro in…

Soft Condensed Matter · Physics 2025-07-31 Amit Kumar , Gary H. Karpen , Samuel A. Safran

Recently, Rozovsky et al. reported on the morphology and dynamics of superstructures in three-component lipid bilayers containing saturated and unsaturated lipids as well as cholesterol [J. Am. Chem. Soc. 127, 36 (2005)]. We comment that…

Soft Condensed Matter · Physics 2012-01-31 S. Komura , N. Shimokawa , D. Andelman

During evaporation in porous media, two types of corner films are distinguished. A continuous corner film is connected to the bulk liquid, while a discontinuous one is not. To disclose their effects on evaporation in porous media, a pore…

Fluid Dynamics · Physics 2021-02-03 Rui Wu , Tao Zhang , Chao Ye , C. Y. Zhao , Evangelos Tsotsas , Abdolreza Kharaghani

Globular proteins as well as recently synthesized colloids engineered with differently charged surface regions have in common a reduced bonding valence and a complex interaction pattern dominated by like-charge attraction and…

Soft Condensed Matter · Physics 2024-02-02 Daniele Notarmuzi , Emanuela Bianchi

We present a theory for phase-separated liquid coacervates with salt, taking into account spatial heterogeneities and interfacial profiles. We find that charged layers of alternating sign can form around the interface while the bulk phases…

Soft Condensed Matter · Physics 2024-08-07 Arghya Majee , Christoph A. Weber , Frank Jülicher

Bilayer lipid membranes [BLMs] are an essential component of all biological systems, forming a functional barrier for cells and organelles from the surrounding environment. The lipid molecules that form membranes contain both permanent and…

Biological Physics · Physics 2015-03-17 Richard J. Bingham , Peter D. Olmsted , Stephen W. Smye

Motivated by observations of heterogeneous domain structure on the surface of cells, we consider a minimal model to describe the dynamics of phase separation on the surface of a spherical particle. Finite-size effects on the curved particle…

Soft Condensed Matter · Physics 2016-07-13 Matthias C. Bott , Joseph M. Brader

Liquid-liquid phase separation of charge/aromatic-enriched intrinsically disordered proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the physics of this recent discovery remains to be elucidated.…

Biomolecules · Quantitative Biology 2016-10-18 Yi-Hsuan Lin , Julie D. Forman-Kay , Hue Sun Chan

The influence of immobile filler particles (spheres, fibers, platelets) on polymer blend phase separation is investigated computationally using a generalization of the Cahn-Hilliard-Cook (CHC) model. Simulation shows that the selective…

Statistical Mechanics · Physics 2007-05-23 Benjamin P. Lee , Jack F. Douglas , Sharon C. Glotzer

We employ the state-of-the-art molecular dynamics simulations to study the kinetics of phase separation and aging phenomena of segregating binary fluid mixtures imbibed in porous materials. Different random porous structures are considered…

Soft Condensed Matter · Physics 2022-12-07 Rounak Bhattacharyya , Bhaskar Sen Gupta

A computationally efficient method to calculate the capillary pressure-saturation relations of immiscible multiphase flow on two-dimensional pore morphologies is presented here. The method is an extension of the Pore Morphology Method that…

Soft Condensed Matter · Physics 2025-01-14 Fernando Alonso-Marroquin , Martin P. Andersson

Liquid water within the cathode Gas Diffusion Layer (GDL) and Gas Channel (GC) of Proton Exchange Membrane Fuel Cells (PEMFCs) is strongly coupled to gas transport properties, thereby affecting the electrochemical conversion rates. In this…

Fluid Dynamics · Physics 2023-02-16 Danan Yang , Himani Garg , Martin Andersson

We have investigated the effect of a disordered porous matrix on the cluster microphase formation of a two dimensional system where particles interact via competing interactions. To this end we have performed extensive Monte Carlo…

Soft Condensed Matter · Physics 2012-02-22 D. F. Schwanzer , G. Kahl

We investigate pores in fluid membranes by molecular dynamics simulations of an amphiphile-solvent mixture, using a molecular coarse-grained model. The amphiphilic membranes self-assemble into a lamellar stack of amphiphilic bilayers…

Soft Condensed Matter · Physics 2009-11-11 Claire Loison , Michel Mareschal , Friederike Schmid

Understanding how pore structure influences flow and transport behaviour in granular materials is essential for addressing a wide range of geotechnical, hydraulic, and environmental challenges. These processes are largely shaped by the…

Soft Condensed Matter · Physics 2025-12-01 Jie Qi , Wenbin Fei , Guillermo A. Narsilio

We review recent work on the phase behaviour of binary charged sphere mixtures as a function of particle concentration and composition. Both size ratios and charge ratios are varied over a wide range. By contrast to hard spheres the long…

Cationic lipid membranes are known to form compact complexes with DNA and to be effective as gene delivery agents both in vitro and in vivo. Here we employ molecular dynamics simulations for a detailed atomistic study of lipid bilayers…

Soft Condensed Matter · Physics 2009-11-10 A. A. Gurtovenko , Michael Patra , Mikko Karttunen , Ilpo Vattulainen