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We describe an approach to model genetic regulatory networks at the level of promotion-inhibition circuitry through a class of stochastic spin models that includes spatial and temporal density fluctuations in a natural way. The formalism…

Statistical Mechanics · Physics 2018-03-08 J. Ricardo G. Mendonça , Mário J. de Oliveira

We introduce and analyze a natural class of nonlinear dynamics for spin systems such as the Ising model. This class of dynamics is based on the framework of mass action kinetics, which models the evolution of systems of entities under…

Probability · Mathematics 2024-12-24 Pietro Caputo , Alistair Sinclair

In 2000, Elowitz and Leibler introduced the repressilator--a synthetic gene circuit with three genes that cyclically repress transcription of the next gene--as well as a corresponding mathematical model. Experimental data and model…

Molecular Networks · Quantitative Biology 2019-01-01 Jonathan Tyler , Anne Shiu , Jay Walton

Mixed positive and negative feedback loops are often found in biological systems which support oscillations. In this work we consider a prototype of such systems, which has been recently found at the core of many genetic circuits showing…

Statistical Mechanics · Physics 2015-06-03 Ashok Garai , Bartlomiej Waclaw , Hannes Nagel , Hildegard Meyer-Ortmanns

We study an excitable active rotator with slowly adapting nonlinear feedback and noise. Depending on the adaptation and the noise level, this system may display noise-induced spiking, noise-perturbed oscillations, or stochastic busting. We…

Adaptation and Self-Organizing Systems · Physics 2020-08-26 Igor Franović , Serhiy Yanchuk , Sebastian Eydam , Iva Bačić , Matthias Wolfrum

This paper applies the classical prediction error method (PEM) to the estimation of nonlinear discrete-time models of neuronal systems subject to input-additive noise. While the nonlinear system exhibits excitability, bifurcations, and…

Systems and Control · Electrical Eng. & Systems 2024-02-19 Thiago B. Burghi , Maarten Schoukens , Rodolphe Sepulchre

Asymmetric Ising model, in which coupled spins affect each other differently, plays an important role in diverse fields, from physics to biology to artificial intelligence. We show that coupled parametric oscillators provide a…

Mesoscale and Nanoscale Physics · Physics 2024-06-11 C. Han , M. Wang , B. Zhang , M. I. Dykman , H. B. Chan

A fast harmonic oscillator is linearly coupled with a system of Ising spins that are in contact with a thermal bath, and evolve under a slow Glauber dynamics at dimensionless temperature $\theta$. The spins have a coupling constant…

Statistical Mechanics · Physics 2012-03-26 L. L. Bonilla , A. Prados , A. Carpio

To investigate novel aspects of pattern formation in spin systems, we use a mapping between reactive concentrations in a reaction-diffusion system and spin orientations in a dynamic multiple-spin Ising model. While pattern formation in…

Adaptation and Self-Organizing Systems · Physics 2019-10-15 Mélody Merle , Laura Messio , Julien Mozziconacci

We investigate a stochastic approach to non-equilibrium quantum spin systems based on recent insights linking quantum and classical dynamics. Exploiting a sequence of exact transformations, quantum expectation values can be recast as…

Statistical Mechanics · Physics 2019-01-31 S. De Nicola , B. Doyon , M. J. Bhaseen

Systems with nonreciprocal interactions generically display time-dependent states. These are routinely observed in finite systems, from neuroscience to active matter, in which globally ordered oscillations exist. However, the stability of…

Statistical Mechanics · Physics 2025-04-01 Yael Avni , Michel Fruchart , David Martin , Daniel Seara , Vincenzo Vitelli

The nonlinear response to an oscillating field is calculated for a kinetic trap model with an exponential density of states and the results are compared to those for the model with a Gaussian density of states. The calculations are limited…

Soft Condensed Matter · Physics 2015-06-22 Gregor Diezemann

We study the dynamical response of a two-dimensional Ising model subject to a square-wave oscillating external field. In contrast to earlier studies, the system evolves under a so-called soft Glauber dynamic [P.A. Rikvold and M. Kolesik, J.…

Statistical Mechanics · Physics 2008-11-14 Gloria M. Buendia , Per Arne Rikvold

Periodic recurrence is a prominent behavioural of many biological phenomena, including cell cycle and circadian rhythms. Although deterministic models are commonly used to represent the dynamics of periodic phenomena, it is known that they…

Formal Languages and Automata Theory · Computer Science 2024-05-16 Paolo Ballarini , Mahmoud Bentriou , Paul-Henry Cournède

The analytical description of the dynamics in models with discrete variables (e.g. Ising spins) is a notoriously difficult problem, that can be tackled only under some approximation. Recently a novel variational approach to solve the…

Disordered Systems and Neural Networks · Physics 2017-04-27 Eduardo Dominguez , Gino Del Ferraro , Federico Ricci-Tersenghi

Oscillations in nonequilibrium noisy systems are important physical phenomena. These oscillations can happen in autonomous biochemical oscillators such as circadian clocks. They can also manifest as subharmonic oscillations in periodically…

Statistical Mechanics · Physics 2019-12-25 Daniele De Martino , Andre C Barato

An ensemble of uncoupled limit-cycle oscillators receiving common Poisson impulses shows a range of non-trivial behavior, from synchronization, desynchronization, to clustering. The group behavior that arises in the ensemble can be…

Adaptation and Self-Organizing Systems · Physics 2009-03-12 Kensuke Arai , Hiroya Nakao

Biomolecular feedback systems are now a central application area of interest within control theory. While classical control techniques provide invaluable insight into the function and design of both natural and synthetic biomolecular…

Systems and Control · Electrical Eng. & Systems 2019-11-15 Noah Olsman , Fulvio Forni

Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing…

Biological Physics · Physics 2017-05-17 Joris Paijmans , David K Lubensky , Pieter Rein ten Wolde

We consider an ensemble of coupled nonlinear noisy oscillators demonstrating in the thermodynamic limit an Ising-type transition. In the ordered phase and for finite ensembles stochastic flips of the mean field are observed with the rate…

Statistical Mechanics · Physics 2009-11-07 A. Pikovsky , A. Zaikin , M. A. de la Casa
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