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Objective: Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires the iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier…

Objective: We propose a semiautomatic pipeline for radiation therapy treatment planning, combining ideas from machine learning-automated planning and multicriteria optimization (MCO). Approach: Using knowledge extracted from historically…

Medical Physics · Physics 2022-02-16 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Online adaptive radiotherapy (ART) requires accurate and efficient auto-segmentation of target volumes and organs-at-risk (OARs) in mostly cone-beam computed tomography (CBCT) images. Propagating expert-drawn contours from the pre-treatment…

Computer Vision and Pattern Recognition · Computer Science 2023-05-10 Xiao Liang , Jaehee Chun , Howard Morgan , Ti Bai , Dan Nguyen , Justin C. Park , Steve Jiang

We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…

Tissues and Organs · Quantitative Biology 2015-06-05 Hamidreza Badri , Yoichi Watanabe , Kevin Leder

This study introduces a novel metric, Plan Aperture Modulation (PAM), developed to quantify the modulation of radiotherapy treatment plans. PAM aims to provide a clear geometric interpretation, addressing the limitations of previous…

Medical Physics · Physics 2025-11-25 Victor Hernandez , Iñigo Lara-Aristimuño , Ruben Abella , Jordi Saez

We conduct a theoretical study of various solution methods for the adaptive fractionation problem. The two messages of this paper are: (i) dynamic programming (DP) is a useful framework for adaptive radiation therapy, particularly adaptive…

Medical Physics · Physics 2012-02-16 Jagdish Ramakrishnan , David Craft , Thomas Bortfeld , John N. Tsitsiklis

Today, intensity-modulated radiation therapy (IMRT) is one of the methods used to treat brain tumors. In conventional treatment planning methods, after identifying planning target volume (PTV), and organs at risk (OARs), and determining the…

Quantitative Methods · Quantitative Biology 2023-05-15 Mobina Naeemi , Mohamad Reza Esmaeili , Iraj Abedi

Purpose: HDR brachytherapy is a widely adopted modality for cancer treatment. However, it is not free from error and uncertainty. In-vivo dosimetry (IVD) is the only technique that can confirm correct dose delivery. This study details and…

Medical Physics · Physics 2025-12-10 Chahrazed Ghannoudi , Marie-Claude Lavallee , Benjamin Cote , Luc Beaulieu

Purpose: A novel rotating gamma stereotactic radiosurgery (SRS) system (Galaxy RTi) with real-time image guidance technology has been developed for high-precision SRS and frameless fractionated stereotactic radiotherapy (SRT). This work…

Medical Physics · Physics 2022-10-11 Huan Liu , Ahmed Eldib , Lili Chen , Bin Wang , Shidong Li , Curtis Miyamoto , CM Charlie Ma

Dose prediction is an area of ongoing research that facilitates radiotherapy planning. Most commercial models utilise imaging data and intense computing resources. This study aimed to predict the dose-volume of rectum and bladder from…

Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at…

The formation of twin images in digital inline holography (DIH) prevents the placement of the focal plane in the center of a sample volume for DIH-based particle tracking velocimetry (DIH-PTV) with a single camera. As a result, it is…

Fluid Dynamics · Physics 2020-04-22 Zhou Zhou , Santosh Kumar Sankar , Kevin Mallery , Wensheng Jiang , Jiarong Hong

Automated segmentation of medical imaging is of broad interest to clinicians and machine learning researchers alike. The goal of segmentation is to increase efficiency and simplicity of visualization and quantification of regions of…

Image and Video Processing · Electrical Eng. & Systems 2020-06-04 Shruti Jadon , Owen P. Leary , Ian Pan , Tyler J. Harder , David W. Wright , Lisa H. Merck , Derek L. Merck

Purpose: To develop an algorithm for real-time volumetric image reconstruction and 3D tumor localization based on a single x-ray projection image for lung cancer radiotherapy. Methods: Given a set of volumetric images of a patient at N…

Medical Physics · Physics 2015-05-18 Ruijiang Li , Xun Jia , John H. Lewis , Xuejun Gu , Michael Folkerts , Chunhua Men , Steve B. Jiang

To facilitate a prospective estimation of CT effective dose and risk minimization process, a prospective spatial dose estimation and the known anatomical structures are expected. To this end, a CT reconstruction method is required to…

Image and Video Processing · Electrical Eng. & Systems 2024-01-24 Chang Liu , Laura Klein , Yixing Huang , Edith Baader , Michael Lell , Marc Kachelrieß , Andreas Maier

Purpose: To develop a machine learning-based, 3D dose prediction methodology for Gamma Knife (GK) radiosurgery. The methodology accounts for cases involving targets of any number, size, and shape. Methods: Data from 322 GK treatment plans…

Medical Physics · Physics 2023-01-09 Binghao Zhang , Aaron Babier , Timothy C. Y. Chan , Mark Ruschin

Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer - a free…

Computer Vision and Pattern Recognition · Computer Science 2013-03-06 Jan Egger , Tina Kapur , Andriy Fedorov , Steve Pieper , James V. Miller , Harini Veeraraghavan , Bernd Freisleben , Alexandra Golby , Christopher Nimsky , Ron Kikinis

Radiotherapy planning is a highly complex process that often varies significantly across institutions and individual planners. Most existing deep learning approaches for 3D dose prediction rely on reference plans as ground truth during…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Riqiang Gao , Simon Arberet , Martin Kraus , Han Liu , Wilko FAR Verbakel , Dorin Comaniciu , Florin-Cristian Ghesu , Ali Kamen

Purpose: The goal of this study is to show the advantage of a collaborative work in the annotation and evaluation of prostate cancer tissues from T2-weighted MRI compared to the commonly used double blind evaluation. Methods: The…

Medical Physics · Physics 2017-08-30 Christian Mata , Alain Lalande , Paul Walker , Arnau Oliver , Joan Martí

A 3D tomographic reconstruction technique is described for inversion of a set of limited-angle high-resolution 2D visible light emission projections (extended in the vertical and toroidal directions) of global MHD eigenmodes in the H-1NF…

Plasma Physics · Physics 2014-08-29 S. R. Haskey , B. D. Blackwell , B. Seiwald , J. Howard