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Simulated Annealing (SA) is a widely used stochastic optimization algorithm, yet much of its theoretical understanding is limited to asymptotic convergence guarantees or general spectral bounds. In this paper, we develop a finite-time…

Systems and Control · Electrical Eng. & Systems 2026-02-11 Hansini Ramachandran , Bhaskar Krishnamachari

Stochastic Approximation (SA) is a classical algorithm that has had since the early days a huge impact on signal processing, and nowadays on machine learning, due to the necessity to deal with a large amount of data observed with…

Optimization and Control · Mathematics 2023-07-18 Aymeric Dieuleveut , Gersende Fort , Eric Moulines , Hoi-To Wai

Molecular dynamics (MD) simulations are useful in obtaining thermodynamic and kinetic properties of bio-molecules but are limited by the timescale barrier, i.e., we may be unable to efficiently obtain properties because we need to run…

Chemical Physics · Physics 2017-08-23 Surl-Hee Ahn , Jay W. Grate , Eric F. Darve

Surfaces serve as highly efficient catalysts for a vast variety of chemical reactions. Typically, such surface reactions involve billions of molecules which diffuse and react over macroscopic areas. Therefore, stochastic fluctuations are…

Statistical Mechanics · Physics 2007-10-12 B. Barzel , O. Biham

Various kinetic Monte Carlo algorithms become inefficient when some of the population sizes in a system are large, which gives rise to a large number of reaction events per unit time. Here, we present a new acceleration algorithm based on…

Quantitative Methods · Quantitative Biology 2019-07-24 Yen Ting Lin , Song Feng , William S. Hlavacek

Biochemical systems are inherently stochastic, particularly those with small-molecule populations. The spatial distribution of molecules plays a critical role and requires the inclusion of spatial coordinates in their analysis. Stochastic…

Molecular Networks · Quantitative Biology 2025-05-15 Manuel Eduardo Hernández-García , Eduardo Moreno-Barbosa , Jorge Velázquez-Castro

Recent years have seen unprecedented advance in the design and control of quantum computers. Nonetheless, their applicability is still restricted and access remains expensive. Therefore, a substantial amount of quantum algorithms research…

Quantum Physics · Physics 2020-12-11 Thomas Grurl , Richard Kueng , Jürgen Fuß , Robert Wille

This article presents an algorithm that allows modeling of biological networks in a qualitative framework with continuous time. Mathematical modeling is used as a systems biology tool to answer biological questions, and more precisely, to…

Molecular Networks · Quantitative Biology 2012-05-30 Gautier Stoll , Eric Viara , Emmanuel Barillot , Laurence Calzone

Complex behaviour in many systems arises from the stochastic interactions of spatially distributed particles or agents. Stochastic reaction-diffusion processes are widely used to model such behaviour in disciplines ranging from biology to…

Statistical Mechanics · Physics 2016-08-23 David Schnoerr , Ramon Grima , Guido Sanguinetti

We propose an efficient probabilistic method to solve a deterministic problem -- we present a randomized optimization approach that drastically reduces the enormous computational cost of optimizing designs under many load cases for both…

Optimization and Control · Mathematics 2017-10-11 Xiaojia Zhang , Eric de Sturler , Glaucio H. Paulino

Sequential Monte Carlo (SMC) algorithms represent a suite of robust computational methodologies utilized for state estimation and parameter inference within dynamical systems, particularly in real-time or online environments where data…

Enzyme kinetics has historically been described by deterministic models, with the Michaelis-Menten (MM) equation serving as a paradigm. However, recent experimental and theoretical advances have made it clear that stochastic fluctuations,…

Molecular Networks · Quantitative Biology 2025-04-08 Jiaji Qu , Malini Rajbhandari

The Stochastic Weighted Particle Method (SWPM) of Rjasanow and Wagner is a generalization of the Direct Simulation Monte Carlo method for computing the probability density function of the velocities of a system of interacting particles for…

Numerical Analysis · Mathematics 2025-09-17 Matthew Goeckner , Donovan Harcey , Rainier Q Pederson , Axel Niyonzima , John Zweck

This paper proposes a neural stochastic optimization method for efficiently solving the two-stage stochastic unit commitment (2S-SUC) problem under high-dimensional uncertainty scenarios. The proposed method approximates the second-stage…

Systems and Control · Electrical Eng. & Systems 2026-04-16 Zhentong Shao , Jingtao Qin , Nanpeng Yu

Higher-order dynamics refer to mechanisms where collective mutual or synchronous interactions differ fundamentally from their pairwise counterparts through the concept of many-body interactions. Phenomena absent in pairwise models, such as…

Physics and Society · Physics 2025-09-25 Hugo P. Maia , Wesley Cota , Yamir Moreno , Silvio C. Ferreira

To improve mathematical models of epidemics it is essential to move beyond the traditional assumption of homogeneous well--mixed population and involve more precise information on the network of contacts and transport links by which a…

Physics and Society · Physics 2023-08-25 Sergey V. Dolgov , Dmitry V. Savostyanov

Spatially-coupled (SC) codes, known for their threshold saturation phenomenon and low-latency windowed decoding algorithms, are ideal for streaming applications and data storage systems. SC codes are constructed by partitioning an…

Information Theory · Computer Science 2021-09-21 Siyi Yang , Ahmed Hareedy , Robert Calderbank , Lara Dolecek

The chemical master equation (CME) is frequently used in systems biology to quantify the effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. The CME is a system of ordinary differential equations…

Quantitative Methods · Quantitative Biology 2017-10-25 Ankit Gupta , Jan Mikelson , Mustafa Khammash

Quantum trajectories and superoperator algorithms implemented within the matrix product state (MPS) framework are powerful tools to simulate the real-time dynamics of open dissipative quantum systems. As for the unitary case, the reachable…

Quantum Gases · Physics 2014-11-19 Lars Bonnes , Andreas M. Läuchli

Stochastic Optimization is a cornerstone of operations research, providing a framework to solve optimization problems under uncertainty. Despite the development of numerous algorithms to tackle these problems, several persistent challenges…

Optimization and Control · Mathematics 2025-03-28 Di Zhang , Suvrajeet Sen
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