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Reconstructing pathogen dynamics from genetic data as they become available during an outbreak or epidemic represents an important statistical scenario in which observations arrive sequentially in time and one is interested in performing…

Populations and Evolution · Quantitative Biology 2020-02-04 Mandev S. Gill , Philippe Lemey , Marc A. Suchard , Andrew Rambaut , Guy Baele

The World Health Organization describes zoonotic diseases as a major pandemic threat, and modeling the behavior of such diseases is a key component of their control. Many emerging zoonoses, such as SARS, Nipah, and Hendra, mutated from…

Populations and Evolution · Quantitative Biology 2021-01-27 Katherine P. Royce , Feng Fu

We study an epidemic propagation between $M$ population centra. The novelty of the model is in analyzing the migration of host (remaining in the same centre) and guest (migrated to another centre) populations separately. Even in the…

Populations and Evolution · Quantitative Biology 2014-01-28 Igor Sazonov , Mark Kelbert , Michael B. Gravenor

Consider the following stochastic model for immune response. Each pathogen gives birth to a new pathogen at rate $\lambda$. When a new pathogen is born, it has the same type as its parent with probability $1 - r$. With probability $r$, a…

Probability · Mathematics 2007-05-23 Thomas M. Liggett , Rinaldo B. Schinazi , Jason Schweinsberg

In reliability and life data analysis, the Weibull distribution is widely used to accommodate more data characteristics by changing the values of the parameters. We frequently observe many zeros or close to zero data points in reliability…

Methodology · Statistics 2022-06-06 Sumangal Bhattacharya , Ishapathik Das , Muralidharan Kunnummal

This paper discusses low mass, metal poor stars, presenting new evolutionary computations which take into account the inward diffusion of both He and heavy elements during the H burning phase. The investigation has been extended to He…

Astrophysics · Physics 2007-05-23 V. Castellani , F. Ciacio , S. Degl'Innocenti , G. Fiorentini

In current paper, we put forward a reaction-diffusion system for West Nile virus in spatial heterogeneous and time almost periodic environment with free boundaries to investigate the influences of the habitat differences and seasonal…

Analysis of PDEs · Mathematics 2020-12-29 Chengcheng Cheng , Zuohuan Zheng

Bovine spongiform encephalopathy, otherwise known as mad cow disease, can spread when an individual cow consumes feed containing the infected tissues of another individual, forming a one-species feedback loop. Such feedback is the primary…

Populations and Evolution · Quantitative Biology 2015-11-17 Richard Barnes , Clarence Lehman

In a short article submitted to ArXiv [1], Maddamsetti et al. argue that the variation in the neutral mutation rate among genes in Escherichia coli that we recently reported [2] might be explained by horizontal gene transfer (HGT). To…

Populations and Evolution · Quantitative Biology 2012-11-08 Inigo Martincorena , Nicholas M. Luscombe

Recent outbreaks of monkeypox and Ebola, and worrying waves of COVID-19, influenza and respiratory syncytial virus, have all led to a sharp increase in the use of epidemiological models to estimate key epidemiological parameters. The…

Populations and Evolution · Quantitative Biology 2023-12-01 B. K. M. Case , Jean-Gabriel Young , Laurent Hébert-Dufresne

Motile organisms can form stable agglomerates such as cities or colonies. In the outbreak of a highly contagious disease, the control of large-scale epidemic spread depends on factors like the number and size of agglomerates, travel rate…

Populations and Evolution · Quantitative Biology 2023-04-03 Pablo de Castro , Felipe Urbina , Ariel Norambuena , Francisca Guzmán-Lastra

Although traditional models of epidemic spreading focus on the number of infected, susceptible and recovered individuals, a lot of attention has been devoted to integrate epidemic models with population genetics. Here we develop an…

Populations and Evolution · Quantitative Biology 2021-11-24 Vitor M. Marquioni , Marcus A. M. de Aguiar

Improvement of protein function by evolution (natural selection) is expected on general grounds, but even with the modern database positive proof has remained a difficult problem for theory. Here we extend our recent analysis of the…

Other Quantitative Biology · Quantitative Biology 2021-12-10 J. C. Phillips

Mathematical models of cholera and waterborne disease vary widely in their structures, in terms of transmission pathways, loss of immunity, and other features. These differences may yield different predictions and parameter estimates from…

Populations and Evolution · Quantitative Biology 2016-05-24 Elizabeth C. Lee , Michael R. Kelly , Brad M. Ochocki , Segun M. Akinwumi , Karen E. S. Hamre , Joseph H. Tien , Marisa C. Eisenberg

Viruses constantly undergo mutations with genomic changes. The propagation of variants of viruses is an interesting problem. We perform numerical simulations of the microscopic epidemic model based on network theory for the spread of…

Populations and Evolution · Quantitative Biology 2025-01-14 Yutaka Okabe , Akira Shudo

In this article, we perform an analysis of COVID-19 on one of the South Saharan countries (hot zone), the Senegal (West Africa). Many questions remain unanswered: why the African continent is not very contaminated compared to other…

Populations and Evolution · Quantitative Biology 2020-07-01 Vieux Medoune Ndiaye , Serigne Omar Sarr , Babacar Mbaye Ndiaye

The rubeola virus, commonly known as measles, is one of the major causes of vaccine-preventable deaths among children worldwide. This is the case despite the fact that an effective vaccine is widely available. Even in developed countries…

Populations and Evolution · Quantitative Biology 2014-08-05 Elaine T. Alexander , Savanah D. McMahon , Nicholas Roberts , Emilio Sutti , Daniel Burkow , Miles Manning , Kamuela E. Yong , Sergei Suslov

The genetic evolution of SARS-CoV-2 has caused recurring epidemic waves, understanding its global dispersal patterns is critical for effective surveillance. We developed the Site-based mutation dynamics - Equal Power Sampling (S-EPS)…

We study a susceptible-infected-removed (SIR) model with multiple seeds on a regular random graph. Many researchers have studied the epidemic threshold of epidemic models above which a global outbreak can occur, starting from an…

Physics and Society · Physics 2016-04-06 Takehisa Hasegawa , Koji Nemoto

During the recent pandemic, a rise in COVID-19 cases was followed by a decline in influenza. In the absence of cross-immunity, a potential explanation for the observed pattern is behavioral: non-pharmaceutical interventions (NPIs) designed…

Dynamical Systems · Mathematics 2026-04-20 Leah LeJeune , Omar Saucedo , Lauren M. Childs , Navid Ghaffarzadegan
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