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In a previous work, we gave a metric on the class of semibinary tree-sibling time consistent phylogenetic networks that is computable in polynomial time; in particular, the problem of deciding if two networks of this kind are isomorphic is…

Populations and Evolution · Quantitative Biology 2009-02-27 Gabriel Cardona , Merce Llabres , Francesc Rossello , Gabriel Valiente

The inference of phylogenetic networks, which model complex evolutionary processes including hybridization and gene flow, remains a central challenge in evolutionary biology. Until now, statistically consistent inference methods have been…

Populations and Evolution · Quantitative Biology 2025-10-14 Niels Holtgrefe , Elizabeth S. Allman , Hector Baños , Leo van Iersel , Vincent Moulton , John A. Rhodes , Kristina Wicke

Genetic and comparative genomic studies indicate that extant genomes are more properly considered to be a fusion product of random mutations over generations and genomic material transfers between individuals of different lineages. This has…

Quantitative Methods · Quantitative Biology 2018-01-16 Andreas D. M. Gunawan , Bingxin Lu , Louxin Zhang

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

Populations and Evolution · Quantitative Biology 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

Tree-child networks are a recently-described class of directed acyclic graphs that have risen to prominence in phylogenetics (the study of evolutionary trees and networks). Although these networks have a number of attractive mathematical…

Probability · Mathematics 2023-01-10 François Bienvenu , Amaury Lambert , Mike Steel

Networks are ubiquitous in biology and computational approaches have been largely investigated for their inference. In particular, supervised machine learning methods can be used to complete a partially known network by integrating various…

Machine Learning · Computer Science 2014-04-25 Marie Schrynemackers , Louis Wehenkel , M. Madan Babu , Pierre Geurts

Suppose N is a phylogenetic network indicating a complicated relationship among individuals and taxa. Often of interest is a much simpler network, for example, a species tree T, that summarizes the most fundamental relationships. The…

Populations and Evolution · Quantitative Biology 2015-01-30 Stephen J. Willson

The comprehensive characterization of the structure of complex networks is essential to understand the dynamical processes which guide their evolution. The discovery of the scale-free distribution and the small world property of real…

Computational Physics · Physics 2009-11-13 Paulino R. Villas Boas , Francisco A. Rodrigues , Gonzalo Travieso , Luciano da F. Costa

Phylogenetic trees and networks are graphs used to model evolutionary relationships, with trees representing strictly branching histories and networks allowing for events in which lineages merge, called reticulation events. While the…

Populations and Evolution · Quantitative Biology 2026-04-17 Martin Frohn , Niels Holtgrefe , Leo van Iersel , Mark Jones , Steven Kelk

Tree Containment is a fundamental problem in phylogenetics useful for verifying a proposed phylogenetic network, representing the evolutionary history of certain species. Tree Containment asks whether the given phylogenetic tree (for…

Populations and Evolution · Quantitative Biology 2024-06-14 Arkadiy Dushatskiy , Esther Julien , Leen Stougie , Leo van Iersel

Evolutionary relationships between species are usually represented in phylogenies, i.e. evolutionary trees, which are a type of networks. The terminal nodes of these trees represent species, which are made of individuals and populations…

Populations and Evolution · Quantitative Biology 2007-07-11 E. Hernandez-Garcia , E. A. Herrada , A. F. Rozenfeld , C. J. Tessone , V. M. Eguiluz , C. M. Duarte , S. Arnaud-Haond , E. Serrao

Many network applications are based on binary-state networks, where each component has one of two states: success or failure. Efficient algorithms to evaluate binary-state network reliability are continually being developed. Reliability…

Networking and Internet Architecture · Computer Science 2020-12-01 Wei-Chang Yeh

Construction of phylogenetic trees has traditionally focused on binary trees where all species appear on leaves, a problem for which numerous efficient solutions have been developed. Certain application domains though, such as viral…

Data Structures and Algorithms · Computer Science 2016-11-01 Dimitris Papamichail , Angela Huang , Andrew Miller , Edward Kennedy , Jan-Lucas Ott , Georgios Papamichail

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

Molecular Networks · Quantitative Biology 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

Phylogenetic networks are a flexible model of evolution that can represent reticulate evolution and handle complex data. Tree-based networks, which are phylogenetic networks that have a spanning tree with the same root and leaf-set as the…

Combinatorics · Mathematics 2023-05-25 Takatora Suzuki , Han Guo , Momoko Hayamizu

Phylogenetic networks provide a way to describe and visualize evolutionary histories that have undergone so-called reticulate evolutionary events such as recombination, hybridization or horizontal gene transfer. The level k of a network…

Populations and Evolution · Quantitative Biology 2008-07-21 Leo van Iersel , Steven Kelk , Matthias Mnich

Rare events have played an increasing role in molecular phylogenetics as potentially homoplasy-poor characters.In this contribution we analyze the phylogenetic information content from a combinatorial point of view by consid-ering the…

Discrete Mathematics · Computer Science 2017-06-15 Marc Hellmuth , Maribel Hernandez-Rosales , Yangjing Long , Peter F. Stadler

A classic problem in computational biology is constructing a phylogenetic tree given a set of distances between n species. In most cases, a tree structure is too constraining. We consider a circular split network, a generalization of a tree…

Combinatorics · Mathematics 2016-07-26 Satyan L. Devadoss , Samantha Petti

Phylogenetic networks are a generalization of evolutionary or phylogenetic trees that are commonly used to represent the evolution of species which cross with one another. A special type of phylogenetic network is an {\em $X$-cactus}, which…

Populations and Evolution · Quantitative Biology 2021-09-08 Andrew Francis , Katharina T. Huber , Vincent Moulton , Taoyang Wu

Phylogenetic networks are generalizations of trees that allow for the modeling of non-tree like evolutionary processes. Split networks give a useful way to construct networks with intuitive distance structures induced from the associated…

Combinatorics · Mathematics 2024-09-18 Bryson Kagy , Seth Sullivant