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We review the trade-offs between speed, fluctuations, and thermodynamic cost involved with biological processes in nonequilibrium states, and discuss how optimal these processes are in light of the universal bound set by the thermodynamic…

Biological Physics · Physics 2022-02-28 Yonghyun Song , Changbong Hyeon

The thermodynamic uncertainty relation provides an inequality relating any mean current, the associated dispersion and the entropy production rate for arbitrary non-equilibrium steady states. Applying it here to a general model of a…

Statistical Mechanics · Physics 2017-01-05 Patrick Pietzonka , Andre C. Barato , Udo Seifert

Semi-Markov processes generalize Markov processes by adding temporal memory effects as expressed by a semi-Markov kernel. We recall the path weight for a semi-Markov trajectory and the fact that thermodynamic consistency in equilibrium…

Statistical Mechanics · Physics 2022-04-15 Benjamin Ertel , Jann van der Meer , Udo Seifert

The thermodynamic uncertainty relation expresses a universal trade-off between precision and entropy production, which applies in its original formulation to current observables in steady-state systems. We generalize this relation to…

Statistical Mechanics · Physics 2018-12-06 Timur Koyuk , Udo Seifert , Patrick Pietzonka

We derive a thermodynamic uncertainty relation for general open quantum dynamics, described by a joint unitary evolution on a composite system comprising a system and an environment. By measuring the environmental state after the…

Statistical Mechanics · Physics 2021-01-06 Yoshihiko Hasegawa

We introduce an example of thermodynamic uncertainty relation (TUR) for systems modeled by a one-dimensional generalised Langevin dynamics with memory, determining the motion of a micro-bead driven in a complex fluid. Contrary to TURs…

Statistical Mechanics · Physics 2020-11-06 Ivan Di Terlizzi , Marco Baiesi

Thermodynamic uncertainty relations yield a lower bound on entropy production in terms of the mean and fluctuations of a current. We derive their general form for systems under arbitrary time-dependent driving from arbitrary initial states…

Statistical Mechanics · Physics 2021-01-12 Timur Koyuk , Udo Seifert

Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often…

Statistical Mechanics · Physics 2017-01-20 Andre C Barato , Udo Seifert

Thermodynamic uncertainty relations have emerged as universal bounds on current fluctuations in non-equilibrium systems. Here we derive a new bound for a particular class of run-and-tumble type processes using the mathematical framework of…

Statistical Mechanics · Physics 2019-07-02 Mayank Shreshtha , Rosemary J. Harris

Living systems regulate many aspects of their behavior through periodic oscillations of molecular concentrations, which function as `biochemical clocks.' These clocks are intrinsically subject to thermal fluctuations, so that the duration…

Biological Physics · Physics 2020-08-10 Robert Marsland , Wenping Cui , Jordan M. Horowitz

In classical Markov jump processes, current fluctuations can only be reduced at the cost of increased dissipation. To explore how quantum effects influence this trade-off, we analyze the uncertainty of steady-state currents in Markovian…

Statistical Mechanics · Physics 2021-07-09 Paul Menczel , Eetu Loisa , Kay Brandner , Christian Flindt

The thermodynamic uncertainty relation sets the minimal bound of the cost-precision trade-off relation for dissipative processes. Examining the dynamics of an internally coupled system that is driven by a constant thermodynamic force, we…

Statistical Mechanics · Physics 2018-09-19 Sangwon Lee , Changbong Hyeon , Junghyo Jo

Thermodynamic uncertainty relations (TURs) relate precision to the dissipation rate, yet the inequalities can be far from saturation. Indeed, in catenane molecular motor simulations, we record precision far below the TUR limit. We further…

Statistical Mechanics · Physics 2026-01-14 Alex Albaugh , Rueih-Sheng Fu , Geyao Gu , Todd R. Gingrich

In these lecture notes, the basic principles of stochastic thermodynamics are developed starting with a closed system in contact with a heat bath. A trajectory undergoes Markovian transitions between observable meso-states that correspond…

Statistical Mechanics · Physics 2018-06-13 Udo Seifert

We propose a numerical technique for parameter inference in Markov models of biological processes. Based on time-series data of a process we estimate the kinetic rate constants by maximizing the likelihood of the data. The computation of…

Quantitative Methods · Quantitative Biology 2011-02-15 Aleksandr Andreychenko , Linar Mikeev , David Spieler , Verena Wolf

Biochemical reactions are fundamentally noisy at a molecular scale. This limits the precision of reaction networks, but also allows fluctuation measurements which may reveal the structure and dynamics of the underlying biochemical network.…

Biological Physics · Physics 2018-04-11 Harmen Wierenga , Pieter Rein ten Wolde , Nils B. Becker

Even though irreversibility is one of the major hallmarks of any real life process, an actual understanding of irreversible processes remains still mostly semiempirical. In this paper we formulate a thermodynamic uncertainty principle for…

Statistical Mechanics · Physics 2021-03-17 Rudolf Hanel , Petr Jizba

Machine learning models have emerged as a very effective strategy to sidestep time-consuming electronic-structure calculations, enabling accurate simulations of greater size, time scale and complexity. Given the interpolative nature of…

Molecular motors are in charge of almost every process in the life cycle of cells, such as protein synthesis, DNA replication, and cell locomotion, hence being of crucial importance for understanding the cellular dynamics. However, given…

Statistical Mechanics · Physics 2025-09-05 Adrián Nadal-Rosa , Gonzalo Manzano

Thermodynamic uncertainty relations elucidate the intricate balance between the precision of current and the thermodynamic costs or dissipation, marking a recent and enthralling advancement at the confluence of statistical mechanics,…

Statistical Mechanics · Physics 2024-06-04 Ryohei Yuno , Katsuaki Tanabe
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