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The second law of thermodynamics states that entropy production cannot be negative. Recent developments concerning uncertainty relations in stochastic thermodynamics, such as thermodynamic uncertainty relations and speed limits, have…

Statistical Mechanics · Physics 2023-10-09 Tomohiro Nishiyama , Yoshihiko Hasegawa

Numerical computations have become a pillar of all modern quantitative sciences. Any computation involves modeling--even if often this step is not made explicit--and any model has to neglect details while still being physically accurate.…

Statistical Mechanics · Physics 2022-11-08 Thomas Speck

For Markov processes over discrete configurations, an asymptotic bound on the uncertainty of stochastic fluxes is derived in terms of the harmonic mean of decay rates with respect to the stationary distribution. This bound is necessarily…

Statistical Mechanics · Physics 2024-07-16 Katarzyna Macieszczak

Quantum cycles in established heat engines can be modeled with various quantum systems as working substances. For example, a heat engine can be modeled with an infinite potential well as the working substance to determine the efficiency and…

Quantum Physics · Physics 2021-04-15 Pritam Chattopadhyay , Ayan Mitra , Goutam Paul , Vasilios Zarikas

In the real world, one almost never knows the parameters of a thermodynamic process to infinite precision. Reflecting this, here we investigate how to extend stochastic thermodynamics to systems with uncertain parameters, including…

Statistical Mechanics · Physics 2021-03-17 Jan Korbel , David H. Wolpert

Living systems operate far from thermal equilibrium by converting the chemical potential of ATP into mechanical work to achieve growth, replication or locomotion. Given time series observations of intra-, inter- or multicellular processes,…

Biological Physics · Physics 2021-11-03 Dominic J. Skinner , Jörn Dunkel

Stochastic thermodynamics as reviewed here systematically provides a framework for extending the notions of classical thermodynamics like work, heat and entropy production to the level of individual trajectories of well-defined…

Statistical Mechanics · Physics 2015-06-05 Udo Seifert

We study a Markov random process describing a muscle molecular motor behavior. Every motor is either bound up with a thin filament or unbound. In the bound state the motor creates a force proportional to its displacement from the neutral…

Mathematical Physics · Physics 2009-11-13 Yu. Kondratiev , E. Pechersky , S. Pirogov

Thermodynamic uncertainty relations reveal a fundamental trade-off between the precision of a trajectory observable and entropy production, where the uncertainty of the observable is quantified by its variance. In information theory,…

Statistical Mechanics · Physics 2025-11-25 Yoshihiko Hasegawa , Tomohiro Nishiyama

Closely related to the laws of thermodynamics, the detection and quantification of disequilibria are crucial in unraveling the complexities of nature, particularly those beneath observable layers. Theoretical developments in nonequilibrium…

Statistical Mechanics · Physics 2024-07-23 Pedro E. Harunari

We derive a thermodynamic uncertainty relation for first passage processes in quantum Markov chains. We consider first passage processes that stop after a fixed number of jumps, which contrasts with typical quantum Markov chains which end…

Quantum Physics · Physics 2022-04-21 Yoshihiko Hasegawa

Chemical and biological networks can describe a wide variety of processes, from gene regulatory networks to biochemical oscillations. Modeled by chemical master equations, these processes are inherently stochastic, as fluctuations dominate…

Statistical Mechanics · Physics 2025-12-23 Schuyler B. Nicholson , Luis Pedro García-Pintos

Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which…

Biological Physics · Physics 2008-03-07 Debashish Chowdhury

We generalize the thermodynamic uncertainty relation, providing an entropic upper bound for average fluxes in time-continuous steady-state systems (Gingrich et al., Phys. Rev. Lett. 116, 120601 (2016)), to time-discrete Markov chains and to…

Statistical Mechanics · Physics 2017-10-11 Karel Proesmans , Christian Van den Broeck

We derive a Thermodynamic Uncertainty Relation bounding the mean squared displacement of a Gaussian process with memory, driven out of equilibrium by unbalanced thermal baths and/or by external forces. Our bound is tighter with respect to…

Statistical Mechanics · Physics 2023-05-23 Andrea Plati , Andrea Puglisi , Alessandro Sarracino

Physical systems that power motion and create structure in a fixed amount of time dissipate energy and produce entropy. Whether living or synthetic, systems performing these dynamic functions must balance dissipation and speed. Here, we…

Statistical Mechanics · Physics 2020-12-18 Schuyler B. Nicholson , Luis Pedro Garcia-Pintos , Adolfo del Campo , Jason R. Green

Entropy production characterizes irreversibility. This viewpoint allows us to consider the thermodynamic uncertainty relation, which states that a higher precision can be achieved at the cost of higher entropy production, as a relation…

Statistical Mechanics · Physics 2021-12-09 Yoshihiko Hasegawa

Quantifying energy flows at nanometer scales promises to guide future research in a variety of disciplines, from microscopic control and manipulation, to autonomously operating molecular machines. A general understanding of the…

Statistical Mechanics · Physics 2018-11-26 Steven J. Large , Raphaël Chetrite , David A. Sivak

The problem of estimating entropy production from incomplete information in stochastic thermodynamics is essential for theory and experiments. Whereas a considerable amount of work has been done on this topic, arguably, most of it is…

Statistical Mechanics · Physics 2024-12-17 Pedro E. Harunari , Carlos E. Fiore , Andre C. Barato

Artificial molecular machines are often driven by the periodic variation of an external parameter. This external control exerts work on the system of which a part can be extracted as output if the system runs against an applied load.…

Statistical Mechanics · Physics 2017-07-24 Andre C. Barato , Udo Seifert