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This paper extends the work of Clarke [1] on the Bayesian foundations of the biomagnetic inverse problem. It derives expressions for the expectation and variance of the a posteriori source current probability distribution given a prior…

Medical Physics · Physics 2009-10-31 R. Hasson , S. J. Swithenby

Non-invasive electrophysiology lacks methods that accurately reconstruct whole-brain spatiotemporal dynamics while incorporating individual cortical geometry, leaving current electroencephalography and magnetoencephalography source imaging…

Neurons and Cognition · Quantitative Biology 2026-04-29 Song Wang , Kexin Lou , Chen Wei , Zhiyuan Sheng , Jiahao Tang , Kaining Peng , Xinke Shen , Shuhao Mei , Liang Chen , Dongfeng Gu , Quanying Liu

Source localization in EEG represents a high dimensional inverse problem, which is severely ill-posed by nature. Fortunately, sparsity constraints have come into rescue as it helps solving the ill-posed problems when the signal is sparse.…

Medical Physics · Physics 2015-04-28 Sajib Saha , Rajib Rana , Ya. I. Nesterets , M. Tahtali , Frank de Hoog , T. E. Gureyev

Foundation models pre-trained through masked reconstruction on large-scale EEG data have emerged as a promising paradigm for learning generalizable neural representations across diverse brain-computer interface applications. However, a…

Artificial Intelligence · Computer Science 2026-05-19 Yang Shao , Peiliang Gong , Qun Dai , Daoqiang Zhang

We propose a Bayesian inference framework to estimate uncertainties in inverse scattering problems. Given the observed data, the forward model and their uncertainties, we find the posterior distribution over a finite parameter field…

Numerical Analysis · Mathematics 2020-11-17 Ana Carpio , Sergei Iakunin , Georg Stadler

In the past five years, the use of generative and foundational AI systems has greatly improved the decoding of brain activity. Visual perception, in particular, can now be decoded from functional Magnetic Resonance Imaging (fMRI) with…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Yohann Benchetrit , Hubert Banville , Jean-Rémi King

We propose a Bayesian approach to the problem of multi-reference alignment -- the recovery of signals from noisy, randomly shifted observations. While existing frequentist methods accurately recover the signal at arbitrarily low…

Signal Processing · Electrical Eng. & Systems 2025-10-15 Axel Janson , Joakim Andén

Deep learning is increasingly moving towards a transfer learning paradigm whereby large foundation models are fine-tuned on downstream tasks, starting from an initialization learned on the source task. But an initialization contains…

Machine Learning · Computer Science 2022-05-23 Ravid Shwartz-Ziv , Micah Goldblum , Hossein Souri , Sanyam Kapoor , Chen Zhu , Yann LeCun , Andrew Gordon Wilson

Our ability to extract the maximal amount of information from future observations at gigahertz frequencies depends on our ability to separate the underlying cosmic microwave background (CMB) from galactic and extragalactic foregrounds. We…

Astrophysics · Physics 2007-05-23 J. Jewell , C. R. Lawrence , S. Levin

Analysis of brain imaging scans is critical to understanding the way the human brain functions, which can be leveraged to treat injuries and conditions that affect the quality of life for a significant portion of the human population. In…

Methodology · Statistics 2022-03-02 Daniel Spencer , David Bolin , Mary Beth Nebel , Amanda Mejia

EEG foundation models are typically pretrained on narrow-source clinical archives and evaluated on benchmarks from the same ecosystem, leaving unclear whether representations encode neural physiology or recording-distribution artifacts. We…

Markov chain Monte Carlo (MCMC) methods form one of the algorithmic foundations of Bayesian inverse problems. The recent development of likelihood-informed subspace (LIS) methods offers a viable route to designing efficient MCMC methods for…

Numerical Analysis · Mathematics 2023-03-07 Tiangang Cui , Xin Tong , Olivier Zahm

Reconstructing lens potentials and lensed sources can easily become an underconstrained problem, even when the degrees of freedom are low, due to degeneracies, particularly when potential perturbations superimposed on a smooth lens are…

Astrophysics of Galaxies · Physics 2022-07-27 Georgios Vernardos , Leon V. E. Koopmans

Bioelectric source analysis in the human brain from scalp electroencephalography (EEG) signals is sensitive to the conductivity of the different head tissues. Conductivity values are subject dependent, so non-invasive methods for…

Computational Engineering, Finance, and Science · Computer Science 2019-08-30 Kostiantyn Maksymenko , Maureen Clerc , Théodore Papadopoulo

We develop a new methodology for determining the location and dynamics of brain activity from combined magnetoencephalography (MEG) and electroencephalography (EEG) data. The resulting inverse problem is ill-posed and is one of the most…

Applications · Statistics 2019-07-23 Yin Song , Farouk S. Nathoo , Arif Babul

Two techniques are proposed to alleviate the computational burden of MUltiple SIgnal Classification (MUSIC) algorithm applied to Electroencephalogram (EEG) source localization. A significant reduction was achieved by parsing the cortex…

Neurons and Cognition · Quantitative Biology 2017-07-27 Seyede Mahya Safavi , Beth Lopour , Pai H. Chou

Bayesian inference methods have been widely applied in inverse problems, {largely due to their ability to characterize the uncertainty associated with the estimation results.} {In the Bayesian framework} the prior distribution of the…

Optimization and Control · Mathematics 2019-01-03 Didi Lv , Qingping Zhou , Jae Kyu Choi , Jinglai Li , Xiaoqun Zhang

Reconstructing brain sources is a fundamental challenge in neuroscience, crucial for understanding brain function and dysfunction. Electroencephalography (EEG) signals have a high temporal resolution. However, identifying the correct…

Image and Video Processing · Electrical Eng. & Systems 2026-03-12 Marco Morik , Ali Hashemi , Klaus-Robert Müller , Stefan Haufe , Shinichi Nakajima

Noninvasive reconstruction of cardiac electrical activity from surface electrocardiograms (ECG) involves solving an ill-posed inverse problem. Cardiac electrophysiological (EP) models have been used as important a priori knowledge to…

Image and Video Processing · Electrical Eng. & Systems 2019-05-14 Sandesh Ghimire , John L Sapp , Milan Horacek , Linwei Wang

EEG foundation models aim to learn reusable representations across heterogeneous paradigms, yet existing approaches often use uniform adaptation mechanisms and are typically reported under separate downstream fine-tuning protocols. In this…

Signal Processing · Electrical Eng. & Systems 2026-05-19 Wei Xiong , Jiangtong Li , Kun Zhu , Jie Li
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