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We introduce a method for approximating posterior probabilities of phylogenetic trees and reconstructing ancestral sequences under models of sequence evolution with site-dependence, where standard phylogenetic likelihood computations…

Populations and Evolution · Quantitative Biology 2025-12-30 Yongkang Li , Kevin J. Wiehe , Scott C. Schmidler

Microbiological systems evolve to fulfill their tasks with maximal efficiency. The immune system is a remarkable example, where self-non self distinction is accomplished by means of molecular interaction between self proteins and antigens,…

Cell Behavior · Quantitative Biology 2013-08-26 Marcio Argollo de Menezes , Edgardo Brigatti , Veit Schwämmle

We study an unbiased, discrete time random walk on the nonnegative integers, with the origin absorbing. The process has a history-dependent step length: the walker takes steps of length v while in a region which has been visited before, and…

Statistical Mechanics · Physics 2012-08-27 Ronald Dickman , Francisco Fontenele Araujo, , Daniel ben-Avraham

We study a model for a random walk of two classes of particles (A and B). Where both species are present in the same site, the motion of A's takes precedence over that of B's. The model was originally proposed and analyzed in Maragakis et…

Disordered Systems and Neural Networks · Physics 2015-01-28 Nikolaos Bastas , Michalis Maragakis , Panos Argyrakis , Daniel ben-Avraham , Shlomo Havlin , Shai Carmi

We study a simple random walk on Z^2 with constraints on the axis. Motivation comes from physics when particles (a gas for example, see [Dal88]) are submitted to a local field. In our case we assume that the particle evolves freely in the…

Probability · Mathematics 2023-01-09 Pierre Andreoletti , Pierre Debs

Movements of molecular motors on cytoskeletal filaments are described by directed walks on a line. Detachment from this line is allowed to occur with a small probability. Motion in the surrounding fluid is described by symmetric random…

Statistical Mechanics · Physics 2007-05-23 Theo M. Nieuwenhuizen , Stefan Klumpp , Reinhard Lipowsky

We present the analytical and numerical results of a random walk on the family of small-world graphs. The average access time shows a crossover from the regular to random behavior with increasing distance from the starting point of the…

Statistical Mechanics · Physics 2009-10-31 Sagar A. Pandit , R. E. Amritkar

A theory of fractional kinetics of glial cancer cells is presented. A role of the migration-proliferation dichotomy in the fractional cancer cell dynamics in the outer-invasive zone is discussed an explained in the framework of a continuous…

Cell Behavior · Quantitative Biology 2016-03-23 A. Iomin

We study random walks on large random graphs that are biased towards a randomly chosen but fixed target node. We show that a critical bias strength b_c exists such that most walks find the target within a finite time when b>b_c. For b<b_c,…

Statistical Mechanics · Physics 2009-11-13 Vishal Sood , Peter Grassberger

Graph sampling is a technique to pick a subset of vertices and/ or edges from original graph. Among various graph sampling approaches, Traversal Based Sampling (TBS) are widely used due to low cost and feasibility for many cases, in which…

Social and Information Networks · Computer Science 2022-09-28 Xiao Qi

This work describes a new algorithm for creating a superposition over the edge set of a graph, encoding a quantum sample of the random walk stationary distribution. The algorithm requires a number of quantum walk steps scaling as…

Quantum Physics · Physics 2019-04-26 Simon Apers

We study in-network computation on general network topologies. Specifically, we are given the description of a function, and a network with distinct nodes at which the operands of the function are made available, and a designated sink where…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-22 Iqra Altaf Gillani , Pooja Vyavahare , Amitabha Bagchi

Modeling of polymer chains has received a lot of attention in mathematics. In fact, probabilistic models that naturally arise in statistical mechanics have been widely studied by mathematicians for the very challenging and novel problems…

Probability · Mathematics 2007-05-23 Francesco Caravenna

We consider a model for the dynamics of growing cell populations with heterogeneous mobility and proliferation rate. The cell phenotypic state is described by a continuous structuring variable and the evolution of the local cell population…

Analysis of PDEs · Mathematics 2021-05-20 Tommaso Lorenzi , Benoît Perthame , Xinran Ruan

Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…

Cell Behavior · Quantitative Biology 2018-05-02 Abdul N Malmi-Kakkada , Xin Li , Himadri S. Samanta , Sumit Sinha , D. Thirumalai

We study random walks on the three-strand braid group $B_3$, and in particular compute the drift, or average topological complexity of a random braid, as well as the probability of trivial entanglement. These results involve the study of…

Mathematical Physics · Physics 2009-11-07 R. Voituriez

We consider a minimalistic dynamic model of the idiotypic network of B-lymphocytes. A network node represents a population of B-lymphocytes of the same specificity (idiotype), which is encoded by a bitstring. The links of the network…

Cell Behavior · Quantitative Biology 2015-06-03 Holger Schmidtchen , Mario Thüne , Ulrich Behn

Probabilistic modeling is fundamental to the statistical analysis of complex data. In addition to forming a coherent description of the data-generating process, probabilistic models enable parameter inference about given data sets. This…

Populations and Evolution · Quantitative Biology 2018-05-01 Branden J. Olson , Frederick A. Matsen

We study an abstract model for the co-evolution between mutating viruses and the adaptive immune system. In sequence space, these two populations are localized around transiently dominant strains. Delocalization or error thresholds exhibit…

Populations and Evolution · Quantitative Biology 2015-06-22 Alexander Seeholzer , Erwin Frey , Benedikt Obermayer

We consider random walk on the structure given by a random hypergraph in the regime where there is a unique giant component. We give the asymptotics for hitting times, cover times, and commute times and show that the results obtained for…

Probability · Mathematics 2019-03-05 Amine Helali , Matthias Löwe