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In this paper, we propose a novel concept for engineered molecular communication (MC) systems inspired by animal olfaction. We focus on a multi-user scenario where several transmitters wish to communicate with a central receiver. We assume…

Information Theory · Computer Science 2022-03-09 Vahid Jamali , Helene M. Loos , Andrea Buettner , Robert Schober , H. Vincent Poor

The performance of molecular communication is significantly impacted by the reception process of the messenger molecules. The receptors' size and density, however, have yet to be investigated. In this letter, we analyze the effect of…

Emerging Technologies · Computer Science 2014-11-26 Ali Akkaya , H. Birkan Yilmaz , Chan-Byoung Chae , Tuna Tugcu

Clinical biosensors with low detection limit hold significant promise in the early diagnosis of debilitating diseases. Recent progress in sensor development has led to the demonstration of detection capable of detecting target molecules…

Medical Physics · Physics 2019-12-05 Tuhin Chakrabortty , Chandra R. Murthy , Manoj Varma

The movement of molecules inside living cells is a fundamental feature of biological processes. The ability to both observe and analyse the details of molecular diffusion in vivo at the single molecule and single cell level can add…

Quantitative Methods · Quantitative Biology 2012-11-21 Alex Robson , Kevin Burrage , Mark Leake

Incorporating functional molecules into sensor devices is an emerging field in molecular electronics that aims at exploiting the sensitivity of different molecules to their environment and turning it into an electrical signal. Among the…

Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop a symbol synchronization framework for molecular communication (MC) systems where we consider…

Information Theory · Computer Science 2017-02-24 Vahid Jamali , Arman Ahmadzadeh , Robert Schober

A molecular communication channel is determined by the received signal. Received signal models form the basis for studies focused on modulation, receiver design, capacity, and coding depend on the received signal models. Therefore, it is…

Emerging Technologies · Computer Science 2016-11-21 H. Birkan Yilmaz , Changmin Lee , Yae Jee Cho , Chan-Byoung Chae

We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate. Can such spatial coupling be of benefit for conveying…

Molecular Networks · Quantitative Biology 2015-01-19 Thomas R. Sokolowski , Gašper Tkačik

Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital intracellular signal and that this conversion increases signaling fidelity.…

Molecular Networks · Quantitative Biology 2019-08-28 Edward Roob , Nicola Trendel , Pieter Rein ten Wolde , Andrew Mugler

Active sensing refers to the process of choosing or tuning a set of sensors in order to track an underlying system in an efficient and accurate way. In a wireless environment, among the several kinds of features extracted by traditional…

Information Theory · Computer Science 2016-05-30 Alessandro Biason , Urbashi Mitra , Michele Zorzi

Living cells often need to measure chemical concentrations that vary in time. To this end, they deploy many resources, e.g. receptors, downstream signaling molecules, time and energy. Here, we present a theory for the optimal design of a…

Molecular Networks · Quantitative Biology 2019-02-26 G. Malaguti , P. R. ten Wolde

Living cells deploy many resources to sense their environments, including receptors, downstream signaling molecules, time and fuel. However, it is not known which resources fundamentally limit the precision of sensing, like weak links in a…

Molecular Networks · Quantitative Biology 2014-01-31 Christopher C. Govern , Pieter Rein ten Wolde

The knowledge of cell molecular mechanisms implicated in human diseases is expanding and should be converted into guidelines for deciphering pathological cell signaling and suggesting appropriate treatment. The basic assumption is that…

Molecular Networks · Quantitative Biology 2015-12-17 Inna Kuperstein

This paper focuses on molecular communication (MC) systems where the signaling molecules may participate in a reversible bimolecular reaction in the channel. The motivation for studying these MC systems is that they can realize the concept…

Information Theory · Computer Science 2017-11-02 Vahid Jamali , Nariman Farsad , Robert Schober , Andrea Goldsmith

A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little…

Statistical Mechanics · Physics 2024-07-29 Ardra Suchitran , Sreekanth K Manikandan

Cells are constantly exposed to fluctuating environmental conditions. External signals are sensed, processed and integrated by cellular signal transduction networks, which translate input signals into specific cellular responses by means of…

Molecular Networks · Quantitative Biology 2012-05-29 Pau Rué , Núria Domedel-Puig , Jordi Garcia-Ojalvo , Antonio J. Pons

Molecular communication (MC) is a promising paradigm for applications where traditional electromagnetic communications are impractical. However, decoding chemical signals, especially in multi-transmitter systems, remains a key challenge due…

Signal Processing · Electrical Eng. & Systems 2025-11-05 Vivien Walter , Dadi Bi , Daniel L. Ruiz Blanco , Yansha Deng

The study of Molecular Communication(MC) is more and more prevalence, and channel model of MC plays an important role in the MC System. Since different propagation environment and modulation techniques produce different channel model, most…

Emerging Technologies · Computer Science 2016-03-14 Pengfei Lu , Yang You , Bo Liu , Zhenqiang Wu

Feedback in sensory biochemical networks can give rise to bifurcations in cells' behavioral response. These bifurcations share many properties with thermodynamic critical points. Evidence suggests that biological systems may operate near…

Biological Physics · Physics 2020-12-04 Michael Vennettilli , Amir Erez , Andrew Mugler

We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations. The model describes explicitly the directed motion of the molecular…

Biological Physics · Physics 2017-09-20 Sarah Klein , Cécile Appert-Rolland , Ludger Santen
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