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Cells are complex structures which require considerable amounts of organization via transport of large intracellular cargo. While passive diffusion is often sufficiently fast for the transport of smaller cargo, active transport is necessary…

Biomolecules · Quantitative Biology 2018-08-29 Robert Blackwell , David Jung , Mona Bukenberger , Ana-Sunčana Smith

Molecular communication (MC) studies biological signals that are found in nature. Most MC literature focuses on particle properties, even though many natural phenomena exhibit wave-like behavior. One such signal is sound waves.…

Signal Processing · Electrical Eng. & Systems 2025-12-02 Fatih Merdan , Ozgur B. Akan

Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop several symbol synchronization schemes for molecular communication (MC) systems where we…

Information Theory · Computer Science 2017-09-05 Vahid Jamali , Arman Ahmadzadeh , Robert Schober

Small chemical sensors are subjected to adsorption-desorption fluctuations which usually considered as noise contaminating useful signal. Based on temporal properties of this noise, it is shown that it can be made useful if proper…

General Physics · Physics 2022-07-20 Alexander K. Vidybida

Cellular signaling involves the transmission of environmental information through cascades of stochastic biochemical reactions, inevitably introducing noise that compromises signal fidelity. Each stage of the cascade often takes the form of…

Molecular Networks · Quantitative Biology 2014-08-20 Michael Hinczewski , D. Thirumalai

The functional significance of correlations between action potentials of neurons is still a matter of vivid debates. In particular it is presently unclear how much synchrony is caused by afferent synchronized events and how much is…

Neurons and Cognition · Quantitative Biology 2013-04-09 Matthias Schultze-Kraft , Markus Diesmann , Sonja Grün , Moritz Helias

Multiple experiments show that various submicron particles such as magnetosomes, RNA messengers, viruses, and even much smaller nanoparticles such as globular proteins diffuse anomalously slow in viscoelastic cytosol of living cells. Hence,…

Biological Physics · Physics 2018-11-12 Igor Goychuk

This work is part of an effort to understand the neural basis for our visual system's ability, or failure, to accurately track moving visual signals. We consider here a ring model of spiking neurons, intended as a simplified computational…

Neurons and Cognition · Quantitative Biology 2016-01-13 Guillaume Lajoie , Lai-Sang Young

The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…

Quantitative Methods · Quantitative Biology 2024-07-18 Nathan Quiblier , Jan-Michael Rye , Pierre Leclerc , Henri Truong , Abdelkrim Hannou , Laurent Héliot , Hugues Berry

When it is polarised, a cell develops an asymmetric distribution of specific molecular markers, cytoskeleton and cell membrane shape. Polarisation can occur spontaneously or be triggered by external signals, like gradients of signalling…

Analysis of PDEs · Mathematics 2013-01-18 Vincent Calvez , Nicolas Meunier , Nicolas Muller , Raphael Voituriez

We show how one can measure the signal from slow jumps of a single molecule between metastable positions using a setup where the molecule is fixed to one lead, and one of the coupling strengths is controlled externally. Such a measurement…

Mesoscale and Nanoscale Physics · Physics 2013-04-04 Tero T. Heikkila , Wolfgang Belzig

Both action potentials and mechanosensitive signalling are an important communication mechanisms in plants. Considering an information theoretic framework, this paper explores the effective range of multiple action potentials for a long…

Molecular Networks · Quantitative Biology 2019-11-13 Hamdan Awan , Kareem Zeid , Raviraj S. Adve , Nigel Wallbridge , Carrol Plummer , Andrew W. Eckford

In this paper, we present an analytical model for the diffusive molecular communication (MC) system with a reversible adsorption receiver in a fluid environment. The widely used concentration shift keying (CSK) is considered for modulation.…

Emerging Technologies · Computer Science 2016-06-23 Yansha Deng , Adam Noel , Maged Elkashlan , Arumugam Nallanathan , Karen C. Cheung

The chemotaxis pathway in the bacterium Escherichia coli allows cells to detect changes in external ligand concentration (e.g. nutrients). The pathway regulates the flagellated rotary motors and hence the cells' swimming behaviour, steering…

Cell Behavior · Quantitative Biology 2011-03-04 Diana Clausznitzer , Robert G Endres

We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as a form of evolutionary learning, and look for parameters…

Molecular Networks · Quantitative Biology 2014-08-12 Gabriele Scheler

Living cells often need to extract information from biochemical signals that are noisy. We study how accurately cells can measure chemical concentrations with signaling networks that are linear. For stationary signals of long duration, they…

Molecular Networks · Quantitative Biology 2015-06-11 Christopher C. Govern , Pieter Rein ten Wolde

Cells use biochemical networks to translate environmental information into intracellular responses. These responses can be highly dynamic, but how the information is encoded in these dynamics remains poorly understood. Here we investigate…

Cell Behavior · Quantitative Biology 2017-04-05 Garrett D. Potter , Tommy A. Byrd , Andrew Mugler , Bo Sun

In this paper, we propose a novel design for molecular communication in which both the transmitter and the receiver have, in a 3-dimensional environment, multiple bulges (in RF communication this corresponds to antenna). The proposed system…

Emerging Technologies · Computer Science 2016-11-17 Bonhong Koo , H. Birkan Yilmaz , Andrew Eckford , Chan-Byoung Chae

We consider nanonodes randomly distributed in a circular area and characterize the received signal strength when a pair of these nodes employ molecular communication. Two communication methods are investigated, namely free diffusion and…

Emerging Technologies · Computer Science 2018-01-29 Rafay Iqbal Ansari , Chrysostomos Chrysostomou , Taqwa Saeed , Marios Lestas , Andreas Pitsillides

Active sensing is traditionally defined as the expenditure of energy, typically in the form of movement, for obtaining information. Here, we propose that the combination of reliance on adaptive sensors, the linkage between movement and…

Neurons and Cognition · Quantitative Biology 2026-05-25 Andrew Lamperski , Debojyoti Biswas , Eric S. Fortune , John Guckenheimer , Kathleen Hoffman , Noah J. Cowan
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