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In topological data analysis, we want to discern topological and geometric structure of data, and to understand whether or not certain features of data are significant as opposed to simply random noise. While progress has been made on…

Computational Geometry · Computer Science 2020-01-10 So Mang Han , Taylor Okonek , Nikesh Yadav , Xiaojun Zheng

One-dimensional persistent homology is arguably the most important and heavily used computational tool in topological data analysis. Additional information can be extracted from datasets by studying multi-dimensional persistence modules and…

Algebraic Topology · Mathematics 2023-08-31 Facundo Mémoli , Anastasios Stefanou , Ling Zhou

We characterize structures such as monotonicity, convexity, and modality in smooth regression curves using persistent homology. Persistent homology is a key tool in topological data analysis that detects higher-dimensional topological…

Algebraic Topology · Mathematics 2025-10-28 Satish Kumar , Subhra Sankar Dhar

A multicomplex structure is defined from an ordered lattice of multigraphs. This structure will help us to observe the features of Persistent Homology in this context, its interaction with the ordering and the repercussions of the process…

Algebraic Topology · Mathematics 2025-02-05 Joaquin Diaz Boils

The field of mathematical morphology offers well-studied techniques for image processing. In this work, we view morphological operations through the lens of persistent homology, a tool at the heart of the field of topological data analysis.…

Computational Geometry · Computer Science 2021-03-25 Yu-Min Chung , Sarah Day , Chuan-Shen Hu

0-dimensional persistent homology is known, from a computational point of view, as the easy case. Indeed, given a list of $n$ edges in non-decreasing order of filtration value, one only needs a union-find data structure to keep track of the…

Computational Geometry · Computer Science 2023-12-12 Marc Glisse

Persistent homology is a popular and powerful tool for capturing topological features of data. Advances in algorithms for computing persistent homology have reduced the computation time drastically -- as long as the algorithm does not…

Computational Geometry · Computer Science 2013-10-03 Ulrich Bauer , Michael Kerber , Jan Reininghaus

Topological data analysis (TDA) is an active field of mathematics for quantifying shape in complex data. Standard methods in TDA such as persistent homology (PH) are typically focused on the analysis of data consisting of a single entity…

Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

Topological Data Analysis (TDA) provides tools to describe the shape of data, but integrating topological features into deep learning pipelines remains challenging, especially when preserving local geometric structure rather than…

Machine Learning · Computer Science 2026-04-21 Elena Xinyi Wang , Arnur Nigmetov , Dmitriy Morozov

Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Artificial intelligence-assisted drug design is revolutionizing the pharmaceutical industry. Effective molecular features are crucial for accurate machine learning predictions, and advanced mathematics plays a key role in designing these…

Biomolecules · Quantitative Biology 2024-08-27 Hongsong Feng , Li Shen , Jian Liu , Guo-Wei Wei

Persistent Homology (PH) is a fundamental tool in computational topology, designed to uncover the intrinsic geometric and topological features of data across multiple scales. Originating within the broader framework of Topological Data…

Algebraic Topology · Mathematics 2025-05-13 Aurelie Jodelle Kemme , Collins Amburo Agyingi

Motivated by the problem of dealing with incomplete or imprecise acquisition of data in computer vision and computer graphics, we extend results concerning the stability of persistent homology with respect to function perturbations to…

Algebraic Topology · Mathematics 2010-05-11 Patrizio Frosini , Claudia Landi

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

Many datasets can be viewed as a noisy sampling of an underlying space, and tools from topological data analysis can characterize this structure for the purpose of knowledge discovery. One such tool is persistent homology, which provides a…

Dimensionality reduction is an integral part of data visualization. It is a process that obtains a structure preserving low-dimensional representation of the high-dimensional data. Two common criteria can be used to achieve a dimensionality…

Computational Geometry · Computer Science 2018-06-25 Lin Yan , Yaodong Zhao , Paul Rosen , Carlos Scheidegger , Bei Wang

Appropriately representing elements in a database so that queries may be accurately matched is a central task in information retrieval; recently, this has been achieved by embedding the graphical structure of the database into a manifold in…

Machine Learning · Statistics 2023-07-10 Yueqi Cao , Athanasios Vlontzos , Luca Schmidtke , Bernhard Kainz , Anthea Monod

Different cell types aggregate and sort into hierarchical architectures during the formation of animal tissues. The resulting spatial organization depends (in part) on the strength of adhesion of one cell type to itself relative to other…

Quantitative Methods · Quantitative Biology 2023-08-02 Dhananjay Bhaskar , William Y. Zhang , Alexandria Volkening , Björn Sandstede , Ian Y. Wong

Understanding the response of an output variable to multi-dimensional inputs lies at the heart of many data exploration endeavours. Topology-based methods, in particular Morse theory and persistent homology, provide a useful framework for…

Graphics · Computer Science 2022-08-16 Yarden Livnat , Dan Maljovec , Attila Gyulassy , Dr Baptiste Mouginot , Valerio Pascucci