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Viruses represent the most abundant biological entities on Earth and play a pivotal role in microbial ecosystems, yet, as prominent human pathogens, they are closely linked to human morbidity and mortality. Accurate identification of viral…

Databases · Computer Science 2026-04-30 Wenxi Zhu , Wensheng Gan , Zhenlian Qi

Genotype networks are a method used in systems biology to study the "innovability" of a set of genotypes having the same phenotype. In the past they have been applied to determine the genetic heterogeneity, and stability to mutations, of…

Populations and Evolution · Quantitative Biology 2015-06-17 Giovanni Marco Dall'Olio , Jaume Bertranpetit , Andreas Wagner , Hafid Laayouni

In the studies of network structures, much attention has been devoted to developing approaches to reconstruct networks and predict missing links when edge-related information is given. However, such approaches are not applicable when we are…

Networking and Internet Architecture · Computer Science 2022-12-09 Junyao Kuang , Caterina Scoglio , Kristin Michel

A major issue in the association of genes to neuroimaging phenotypes is the high dimension of both genetic data and neuroimaging data. In this article, we tackle the latter problem with an eye toward developing solutions that are relevant…

Quantitative Methods · Quantitative Biology 2023-07-03 Cédric Beaulac , Sidi Wu , Erin Gibson , Michelle F. Miranda , Jiguo Cao , Leno Rocha , Mirza Faisal Beg , Farouk S. Nathoo

In person re-identification (re-ID), the key task is feature representation, which is used to compute distance or similarity in prediction. Person re-ID achieves great improvement when deep learning methods are introduced to tackle this…

Computer Vision and Pattern Recognition · Computer Science 2019-01-18 Jiabao Wang , Yang Li , Zhuang Miao

We introduce a new centrality measure that characterizes the participation of each node in all subgraphs in a network. Smaller subgraphs are given more weight than larger ones, which makes this measure appropriate for characterizing network…

Statistical Mechanics · Physics 2009-11-11 Ernesto Estrada , Juan A. Rodriguez-Velazquez

Genomes may be analyzed from an information viewpoint as very long strings, containing functional elements of variable length, which have been assembled by evolution. In this work an innovative information theory based algorithm is…

Genomics · Quantitative Biology 2020-09-23 Vincenzo Bonnici , Giuditta Franco , Vincenzo Manca

The DNA microarray technology has modernized the approach of biology research in such a way that scientists can now measure the expression levels of thousands of genes simultaneously in a single experiment. Gene expression profiles, which…

Computational Engineering, Finance, and Science · Computer Science 2011-09-07 G. Victo Sudha George , V. Cyril Raj

We give a new approach to coding sequence (CDS) density estimation in genomic analysis based on the topological pressure, which we develop from a well known concept in ergodic theory. Topological pressure measures the "weighted information…

Dynamical Systems · Mathematics 2014-01-09 David Koslicki , Daniel J. Thompson

Complete genome sequences contain valuable information about natural selection, but extracting this information for short, widely scattered noncoding elements remains a challenging problem. Here we introduce a new computational method for…

Genomics · Quantitative Biology 2015-03-19 Ilan Gronau , Leonardo Arbiza , Jaaved Mohammed , Adam Siepel

Deep neural networks are a powerful tool for feature learning and extraction given their ability to model high-level abstractions in highly complex data. One area worth exploring in feature learning and extraction using deep neural networks…

Machine Learning · Computer Science 2015-12-15 Mohammad Javad Shafiee , Parthipan Siva , Paul Fieguth , Alexander Wong

Being able to capture the characteristics of a time series with a feature vector is a very important task with a multitude of applications, such as classification, clustering or forecasting. Usually, the features are obtained from linear…

Social and Information Networks · Computer Science 2022-02-18 Vanessa Freitas Silva , Maria Eduarda Silva , Pedro Ribeiro , Fernando Silva

Recent progress in encoder-decoder neural network architecture design has led to significant performance improvements in a wide range of medical image segmentation tasks. However, state-of-the-art networks for a given task may be too…

Image and Video Processing · Electrical Eng. & Systems 2021-12-22 Tariq M. Khan , Syed S. Naqvi , Erik Meijering

A measure called Physical Complexity is established and calculated for a population of sequences, based on statistical physics, automata theory, and information theory. It is a measure of the quantity of information in an organism's genome.…

Biological Physics · Physics 2011-12-02 Gerard Briscoe , Philippe De Wilde

Shannon entropy is widely used to measure the complexity of DNA sequences but suffers from saturation effects that limit its discriminative power for long uniform segments. We introduce a novel metric, the entropy rank ratio R, which…

Information Theory · Computer Science 2025-11-10 Emmanuel Pio Pastore , Giuseppe Passarino , Peppino Sapia , Francesco De Rango

This paper introduces a speciation principle for neuroevolution where evolving networks are grouped into species based on the number of hidden neurons, which is indicative of the complexity of the search space. This speciation principle is…

Neural and Evolutionary Computing · Computer Science 2020-10-13 Alexander Hadjiivanov , Alan Blair

Reconstructing components of a genomic mixture from data obtained by means of DNA sequencing is a challenging problem encountered in a variety of applications including single individual haplotyping and studies of viral communities.…

Genomics · Quantitative Biology 2019-11-14 Ziqi Ke , Haris Vikalo

Motivation. Cancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches to link organ- and tissue-level information from diagnostic images and…

Quantitative Methods · Quantitative Biology 2020-05-19 Nova F. Smedley , Suzie El-Saden , William Hsu

We propose an adaptive node feature selection approach for graph neural networks (GNNs) that identifies and removes unnecessary features during training. The ability to measure how features contribute to model output is key for interpreting…

Machine Learning · Computer Science 2026-05-04 Ali Azizpour , Madeline Navarro , Santiago Segarra

While the majority of approaches to the characterization of complex networks has relied on measurements considering only the immediate neighborhood of each network node, valuable information about the network topological properties can be…

Statistical Mechanics · Physics 2015-06-24 Luciano da Fontoura Costa , Filipi Nascimento Silva