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In this paper, we mathematically compared two models of mammalian striated muscle activation dynamics proposed by Hatze and Zajac. Both models are representative of a broad variety of biomechanical models formulated as ordinary differential…

Dynamical Systems · Mathematics 2014-11-25 Robert Rockenfeller , Michael Guenther , Syn Schmitt , Thomas Goetz

The training of deep neural networks is inherently a nonconvex optimization problem, yet standard approaches such as stochastic gradient descent (SGD) require simultaneous updates to all parameters, often leading to unstable convergence and…

Machine Learning · Computer Science 2025-08-07 Chengcheng Yan , Jiawei Xu , Zheng Peng , Qingsong Wang

The eigenvalues and eigenvectors of the Fisher information matrix (FIM) can reveal the most and least sensitive directions of a system and it has wide application across science and engineering. We present a symplectic variant of the…

Information Theory · Computer Science 2023-07-04 Jiannan Yang

Stochastic kinetic models describe systems across biology, chemistry, and physics where discrete events and small populations render deterministic approximations inadequate. Parameter inference and inverse design in these systems require…

Computational Physics · Physics 2026-03-06 Francesco Mottes , Qian-Ze Zhu , Michael P. Brenner

Sensitivity analysis measures the influence of a Bayesian network's parameters on a quantity of interest defined by the network, such as the probability of a variable taking a specific value. In particular, the so-called sensitivity value…

Artificial Intelligence · Computer Science 2022-06-20 Rafael Ballester-Ripoll , Manuele Leonelli

Several different methods exist for efficient approximation of paths in multiscale stochastic chemical systems. Another approach is to use bursts of stochastic simulation to estimate the parameters of a stochastic differential equation…

Numerical Analysis · Mathematics 2014-12-19 Simon Cotter , Radek Erban

Achieving robustness in image segmentation models is challenging due to the fine-grained nature of pixel-level classification. These models, which are crucial for many real-time perception applications, particularly struggle when faced with…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Laura Zheng , Wenjie Wei , Tony Wu , Jacob Clements , Shreelekha Revankar , Andre Harrison , Yu Shen , Ming C. Lin

The global sensitivity analysis method, used to quantify the influence of uncertain input variables on the response variability of a numerical model, is applicable to deterministic computer code (for which the same set of input variables…

Methodology · Statistics 2009-06-08 Bertrand Iooss , Mathieu Ribatet , Amandine Marrel

Anomaly detection in dynamic networks is critical for applications from cybersecurity to industrial monitoring, yet existing methods face challenges in energy efficiency, temporal precision, and adaptability. This paper introduces…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Abdul Joseph Fofanah , Lian Wen , David Chen , Tsungcheng Yao , Kwabena Sarpong

Feature screening for ultrahigh-dimension, in general, proceeds with two essential steps. The first step is measuring and ranking the marginal dependence between response and covariates, and the second is determining the threshold. We…

Methodology · Statistics 2022-07-28 Linsui Deng , Yilin Zhang

We consider the problem of efficiently performing simulation and inference for stochastic kinetic models. Whilst it is possible to work directly with the resulting Markov jump process, computational cost can be prohibitive for networks of…

Computation · Statistics 2015-06-18 Chris Sherlock , Andrew Golightly , Colin Gillespie

As saturated output observations are ubiquitous in practice, identifying stochastic systems with such nonlinear observations is a fundamental problem across various fields. This paper investigates the asymptotically efficient identification…

Machine Learning · Computer Science 2025-04-07 Lantian Zhang , Lei Guo

We introduce a new sequential methodology to calibrate the fixed parameters and track the stochastic dynamical variables of a state-space system. The proposed method is based on the nested hybrid filtering (NHF) framework of [1], that…

Computation · Statistics 2021-03-24 Sara Pérez-Vieites , Joaquín Míguez

Explaining individual differences in cognitive abilities requires both identifying brain parameters that vary across individuals and understanding how brain networks are recruited for specific tasks. Typically, task performance relies on…

Neurons and Cognition · Quantitative Biology 2026-05-05 Sida Chen , Siqi Yang , Zhao Chang , Taro Toyoizumi , Werner Sommer , Lianchun Yu , Qian-Yuan Tang , Changsong Zhou

Differential network is an important tool to capture the changes of conditional correlations under two sample cases. In this paper, we introduce a fast iterative algorithm to recover the differential network for high-dimensional data. The…

Computation · Statistics 2019-01-23 Zhou Tang , Zhangsheng Yu , Cheng Wang

Models of reaction chemistry based on the stochastic simulation algorithm (SSA) have become a crucial tool for simulating complicated biological reaction networks due to their ability to handle extremely complicated reaction networks and to…

Quantitative Methods · Quantitative Biology 2009-11-13 Navodit Misra , Russell Schwartz

This paper presents a novel multimodal human activity recognition system. It uses a two-stream decision level fusion of vision and inertial sensors. In the first stream, raw RGB frames are passed to a part affinity field-based pose…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Santosh Kumar Yadav , Muhtashim Rafiqi , Egna Praneeth Gummana , Kamlesh Tiwari , Hari Mohan Pandey , Shaik Ali Akbara

Discrete-state stochastic models have become a well-established approach to describe biochemical reaction networks that are influenced by the inherent randomness of cellular events. In the last years severalmethods for accurately…

Molecular Networks · Quantitative Biology 2017-07-03 Alexander Lück , Verena Wolf

In a wide range of applications, the stochastic properties of the observed time series change over time. The changes often occur gradually rather than abruptly: the properties are (approximately) constant for some time and then slowly start…

Methodology · Statistics 2015-04-03 Michael Vogt , Holger Dette

Stochastic models are necessary for the realistic description of an increasing number of applications. The ability to identify influential parameters and variables is critical to a thorough analysis and understanding of the underlying…

Computation · Statistics 2016-11-29 Joseph L. Hart , Alen Alexanderian , Pierre A. Gremaud