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In this paper we focus on the development of new methods suitable for efficient and reliable coarse-graining of {\it non-equilibrium} molecular systems. In this context, we propose error estimation and controlled-fidelity model reduction…

Computational Physics · Physics 2015-06-15 Markos A. Katsoulakis , Petr Plechac

A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach…

Born-rule generative modeling, a central task in quantum machine learning, seeks to learn probability distributions that can be efficiently sampled by measuring complex quantum states. One hope is for quantum models to efficiently capture…

Quantum Physics · Physics 2025-12-03 Mark M. Wilde

Neural network quantum states are a promising tool to analyze complex quantum systems given their representative power. It can however be difficult to optimize efficiently and effectively the parameters of this type of ansatz. Here we…

Quantum Physics · Physics 2023-05-10 Wenxuan Zhang , Xiansong Xu , Zheyu Wu , Vinitha Balachandran , Dario Poletti

The techniques of data-driven backmapping from coarse-grained (CG) to fine-grained (FG) representation often struggle with accuracy, unstable training, and physical realism, especially when applied to complex systems such as proteins. In…

Machine Learning · Computer Science 2025-05-26 Georgios Kementzidis , Erin Wong , John Nicholson , Ruichen Xu , Yuefan Deng

Water is a notoriously difficult substance to model both accurately and efficiently. Here, we focus on descriptions with a single coarse-grained particle per molecule using the so-called Approximate Non-Conformal (ANC) and generalized…

Soft Condensed Matter · Physics 2017-10-25 Tonalli Rodríguez-López , Yuriy Khalak , Mikko Karttunen

We propose a method for learning expressive energy-based policies for continuous states and actions, which has been feasible only in tabular domains before. We apply our method to learning maximum entropy policies, resulting into a new…

Machine Learning · Computer Science 2017-07-25 Tuomas Haarnoja , Haoran Tang , Pieter Abbeel , Sergey Levine

This paper introduces an input-output bilinear Koopman realization with an optimization algorithm of lifting functions. For nonlinear systems with inputs, Koopman-based modeling is effective because the Koopman operator enables a…

Systems and Control · Electrical Eng. & Systems 2026-02-18 Shuichi Yahagi , Ansei Yonezawa , Heisei Yonezawa , Hiroki Seto , Itsuro Kajiwara

We introduce a novel approach for decomposing and learning every scale of a given multiscale objective function in $\mathbb{R}^d$, where $d\ge 1$. This approach leverages a recently demonstrated implicit bias of the optimization method of…

Numerical Analysis · Mathematics 2024-01-09 Xingjie Helen Li , Molei Tao

Restricted Boltzmann machines are used for probabilistic learning and are capable of capturing complex dependencies in data. They are employed for diverse purposes such as dimensionality reduction, feature learning and can be used for…

Mesoscale and Nanoscale Physics · Physics 2024-12-10 Rehana Begum Popy , Mahdis Hamdi , Robert L. Stamps

We propose to couple a state-resolved rovibrational coarse-grain model to a stochastic particle method for simulating internal energy excitation and dissociation of a molecular gas. An existing coarse-grain model based on the NASA Ames ab…

Chemical Physics · Physics 2018-11-06 Erik Torres , Thierry E. Magin

We introduce an RG-inspired coarse-graining for extracting the collective features of data. The key to successful coarse-graining lies in finding appropriate pairs of data sets. We coarse-grain the two closest data in a regular real-space…

Data Analysis, Statistics and Probability · Physics 2023-07-19 Jonathan Landy , Tsvi Tlusty , YeongKyu Lee , YongSeok Jho

Most Markov chain Monte Carlo methods operate in discrete time and are reversible with respect to the target probability. Nevertheless, it is now understood that the use of non-reversible Markov chains can be beneficial in many contexts. In…

Methodology · Statistics 2021-02-23 Chris Sherlock , Alexandre H. Thiery

Approximate inference in probability models is a fundamental task in machine learning. Approximate inference provides powerful tools to Bayesian reasoning, decision making, and Bayesian deep learning. The main goal is to estimate the…

Machine Learning · Computer Science 2020-03-10 Jun Han

Conventionally, the dynamic state estimation of variables in power networks is performed based on the forecasting-aided model of bus voltages. This approach is effective in the stiff grids at the transmission level, where the bus voltages…

Systems and Control · Electrical Eng. & Systems 2021-10-26 Bang L. H. Nguyen , Tuyen V. Vu , Thomas H. Ortmeyer , Tuan Ngo

We propose digitized counterdiabatic quantum sampling (DCQS), a hybrid quantum-classical algorithm for efficient sampling from energy-based models, such as low-temperature Boltzmann distributions. The method utilizes counterdiabatic…

Quantum computers are a highly promising tool for efficiently simulating quantum many-body systems. The preparation of their eigenstates is of particular interest and can be addressed, e.g., by quantum phase estimation algorithms. The…

Quantum Physics · Physics 2025-08-28 Xiaoyu Liu , Benjamin F. Schiffer , Jordi Tura

We propose a new multi-scale molecular dynamics simulation method which can achieve high accuracy and high sampling efficiency simultaneously without aforehand knowledge of the coarse grained (CG) potential and test it for a biomolecular…

Biological Physics · Physics 2009-08-05 Wenfei Li , Shoji Takada

The deep extension of the restricted Boltzmann machine (RBM), known as the deep Boltzmann machine (DBM), is an expressive family of machine learning models which can serve as compact representations of complex probability distributions.…

Machine Learning · Computer Science 2021-02-18 Haik Manukian , Massimiliano Di Ventra

Kalman filtering has been traditionally applied in three application areas of estimation, state estimation, parameter estimation (a.k.a. model updating), and dual estimation. However, Kalman filter is often not sufficient when experimenting…

Systems and Control · Electrical Eng. & Systems 2019-11-11 Johnny Condori , Amin Maghareh , Shirley Dyke
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