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We propose sequential multiple testing procedures which control the false discover rate (FDR) or the positive false discovery rate (pFDR) under arbitrary dependence between the data streams. This is accomplished by "optimizing" an upper…

Methodology · Statistics 2024-11-27 Michael Hankin , Jay Bartroff

Databases often contain corrupted, degraded, and noisy data with duplicate entries across and within each database. Such problems arise in citations, medical databases, genetics, human rights databases, and a variety of other applied…

Methodology · Statistics 2015-04-29 Rebecca C. Steorts

In modern multiple hypothesis testing, the availability of covariate information alongside the primary test statistics has motivated the development of more powerful and adaptive inference methods. However, most existing approaches rely on…

Methodology · Statistics 2025-11-20 Taehyoung Kim , Seohwa Hwang , Junyong Park

We study the problem of choosing algorithm hyper-parameters in unsupervised domain adaptation, i.e., with labeled data in a source domain and unlabeled data in a target domain, drawn from a different input distribution. We follow the…

Domain generalization (DG) seeks predictors which perform well on unseen test distributions by leveraging data drawn from multiple related training distributions or domains. To achieve this, DG is commonly formulated as an average- or…

Quasi-probability decompositions (QPDs) have proven essential in many quantum algorithms and protocols -- one replaces a ``difficult'' quantum circuit with an ensemble of ``easier'' circuit variants whose weighted outcomes reproduce any…

Quantum Physics · Physics 2026-02-13 Joshua W. Dai , Bálint Koczor

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a…

Methodology · Statistics 2023-09-22 Jake A. Soloff , Daniel Xiang , William Fithian

Multiple testing is a fundamental problem in high-dimensional statistical inference. Although many methods have been proposed to control false discoveries, it is still a challenging task when the tests are correlated to each other. To…

Statistics Theory · Mathematics 2022-07-06 Meng Mei , Yuan Jiang

In the FDR-controlling literature, mirror statistics offer a flexible alternative to $p$-value based procedures. When prior information is available, however, it is unclear how to incorporate mirror statistics in a principled way, and the…

Methodology · Statistics 2026-04-22 Yuanchuan Guo , Buyu Lin , Jun S. Liu

Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

Quantitative Methods · Quantitative Biology 2025-05-26 Huma Perveen , Julie Weeds

Selecting relevant features associated with a given response variable is an important issue in many scientific fields. Quantifying quality and uncertainty of a selection result via false discovery rate (FDR) control has been of recent…

Methodology · Statistics 2020-12-17 Chenguang Dai , Buyu Lin , Xin Xing , Jun S. Liu

Large language models (LLMs) are increasingly used as decision-support tools in data-constrained scientific workflows, where correctness and validity are critical. However, evaluation practices often emphasize stability or reproducibility…

Machine Learning · Computer Science 2026-03-18 Nazia Riasat

Reinforcement Learning with Verifiable Rewards (RLVR) has emerged as a powerful paradigm for enhancing the reasoning capabilities of LLMs. Existing research has predominantly concentrated on isolated reasoning domains such as mathematical…

Artificial Intelligence · Computer Science 2025-07-24 Yu Li , Zhuoshi Pan , Honglin Lin , Mengyuan Sun , Conghui He , Lijun Wu

While there have been considerable advancements in machine learning driven by extensive datasets, a significant disparity still persists in the availability of data across various sources and populations. This inequality across domains…

Machine Learning · Computer Science 2024-03-11 Jinha Park , Wonguk Cho , Taesup Kim

Efron's two-group model is widely used in large scale multiple testing. This model assumes that test statistics are mutually independent, however in realistic settings they are typically dependent, and taking the dependence into account can…

Methodology · Statistics 2022-12-20 Rajesh Karmakar , Ruth Heller , Saharon Rosset

In many scientific applications, hypotheses are generated and tested continuously in a stream. We develop a framework for improving online multiple testing procedures with false discovery rate (FDR) control under arbitrary dependence. Our…

Methodology · Statistics 2026-03-27 Ziyu Xu , Lasse Fischer , Aaditya Ramdas

Protein structure-based property prediction has emerged as a promising approach for various biological tasks, such as protein function prediction and sub-cellular location estimation. The existing methods highly rely on experimental protein…

Machine Learning · Computer Science 2023-10-20 Yufei Huang , Siyuan Li , Jin Su , Lirong Wu , Odin Zhang , Haitao Lin , Jingqi Qi , Zihan Liu , Zhangyang Gao , Yuyang Liu , Jiangbin Zheng , Stan. ZQ. Li

The need for more transparent face recognition (FR), along with other visual-based decision-making systems has recently attracted more attention in research, society, and industry. The reasons why two face images are matched or not matched…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Marco Huber , Naser Damer

Although achieving remarkable progress, it is very difficult to induce a supervised classifier without any labeled data. Unsupervised domain adaptation is able to overcome this challenge by transferring knowledge from a labeled source…

Machine Learning · Computer Science 2021-06-29 Yuntao Du , Ruiting Zhang , Xiaowen Zhang , Yirong Yao , Hengyang Lu , Chongjun Wang

Unsupervised domain adaptation aims to address the problem of classifying unlabeled samples from the target domain whilst labeled samples are only available from the source domain and the data distributions are different in these two…

Machine Learning · Computer Science 2019-11-20 Qian Wang , Toby P. Breckon
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