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Longitudinal tumour volume data from head-and-neck cancer patients show that tumours of comparable pre-treatment size and stage may respond very differently to the same radiotherapy fractionation protocol. Mathematical models are often…

Entity relationship classification remains a challenging task in information extraction, especially in scenarios with limited labeled data and complex relational structures. In this study, we conduct a comparative analysis of three distinct…

Computation and Language · Computer Science 2026-03-24 Maryam Berijanian , Kuldeep Singh , Amin Sehati

Mathematical oncology is a rapidly evolving interdisciplinary field that uses mathematical models to enhance our understanding of cancer dynamics, including tumor growth, metastasis, and treatment response. Tumor-immune interactions play a…

Quantitative Methods · Quantitative Biology 2025-11-05 Chenghang Li , Jinzhi Lei

In decision support systems, it is essential to get a candidate solution fast, even if it means resorting to an approximation. This constraint introduces a scalability requirement with regard to the kind of heuristics which can be used in…

Multiagent Systems · Computer Science 2014-05-22 D. Krzywicki , Ł. Faber , A. Byrski , M. Kisiel-Dorohinicki

Agent-based models (ABMs) are proliferating as decision-making tools across policy areas in transportation, economics, and epidemiology. In these models, a central object of interest is the discrete origin-destination matrix which captures…

Machine Learning · Computer Science 2025-05-12 Ioannis Zachos , Mark Girolami , Theodoros Damoulas

We introduce a stochastic principal-agent model. A principal and an agent interact in a stochastic environment, each privy to observations about the state not available to the other. The principal has the power of commitment, both to elicit…

Computer Science and Game Theory · Computer Science 2024-09-13 Jiarui Gan , Rupak Majumdar , Debmalya Mandal , Goran Radanovic

The growth of many solid tumors has been found to be driven by chemo- and radiotherapy-resistant cancer stem cells (CSCs). A suitable therapeutic avenue in these cases may involve the use of a differentiating agent (DA) to force the…

Tissues and Organs · Quantitative Biology 2023-03-09 Jerónimo Fotinós , Lucas Barberis , Carlos A. Condat

Bias exists in how we pick leaders, who we perceive as being influential, and who we interact with, not only in society, but in organizational contexts. Drawing from leadership emergence and social influence theories, we investigate…

Multiagent Systems · Computer Science 2023-04-06 Andria L. Smith , Simon Heuschkel , Ksenia Keplinger , Charley M. Wu

We present briefly the Nondeterministic Waiting Time algorithm. Our technique for the simulation of biochemical reaction networks has the ability to mimic the Gillespie Algorithm for some networks and solutions to ordinary differential…

Formal Languages and Automata Theory · Computer Science 2009-07-28 John Jack , Andrei Paun

As large language models (LLMs) continue to make significant strides, their better integration into agent-based simulations offers a transformational potential for understanding complex social systems. However, such integration is not…

Physics and Society · Physics 2024-05-14 Onder Gurcan

Risk management resulting from the actions and states of the different elements making up a operating room is a major concern during a surgical procedure. Agent-based simulation shows an interest through its interaction concepts,…

Artificial Intelligence · Computer Science 2020-07-23 Bruno Perez , Julien Henriet , Christophe Lang , Laurent Philippe

Cell proliferation and cell movement are fundamentally stochastic processes which lead to variability in the growth and spatial structure of cell populations in many biological settings, such as cell invasion, wound healing, and tumour…

Cell Behavior · Quantitative Biology 2026-04-23 John Carlo Dimaculangan , Cameron A. Smith , Christian A. Yates

Designing and evaluating personalized and proactive assistant agents remains challenging due to the time, cost, and ethical concerns associated with human-in-the-loop experimentation. Existing Human-Computer Interaction (HCI) methods often…

Human-Computer Interaction · Computer Science 2025-11-25 Ziyi Xuan , Yiwen Wu , Xuhai Xu , Vinod Namboodiri , Mooi Choo Chuah , Yu Yang

Motivated by a general principle governing regulation mechanisms in biological cells, we investigate a general interaction scheme between different populations of particles and specific particles, referred to as agents. Assuming that each…

Probability · Mathematics 2023-10-10 Vincent Fromion , Philippe Robert , Jana Zaherddine

Computer simulations offer a robust toolset for exploring complex systems across various disciplines. A particularly impactful approach within this realm is Agent-Based Modeling (ABM), which harnesses the interactions of individual agents…

Artificial Intelligence · Computer Science 2023-12-19 Zengqing Wu , Run Peng , Xu Han , Shuyuan Zheng , Yixin Zhang , Chuan Xiao

In this study, we present a stochastic simulation model designed to explicitly incorporate cell cycle length, overcoming limitations associated with classical compartmental models. Our approach employs a delay mechanism to represent the…

Populations and Evolution · Quantitative Biology 2025-04-01 Peter Boldog , Gergely Röst

Multi-agent systems often operate under feedback, adaptation, and non-stationarity, yet many simulation studies retain static decision rules and fixed control parameters. This paper introduces a general adaptive multi-agent learning…

Multiagent Systems · Computer Science 2025-11-26 Roberto Garrone

Online mental health communities (OMHCs) are an effective and accessible channel to give and receive social support for individuals with mental and emotional issues. However, a key challenge on these platforms is finding suitable partners…

Human-Computer Interaction · Computer Science 2023-03-21 Yuhan Liu , Anna Fang , Glen Moriarty , Robert Kraut , Haiyi Zhu

The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

Biomolecules · Quantitative Biology 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King

Multi-agent systems often require agents to collaborate with or compete against other agents with diverse goals, behaviors, or strategies. Agent modeling is essential when designing adaptive policies for intelligent machine agents in…

Multiagent Systems · Computer Science 2025-07-29 Wenhao Ma , Yu-Cheng Chang , Jie Yang , Yu-Kai Wang , Chin-Teng Lin