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Recurrent neural networks (RNNs) have been applied to a broad range of applications, including natural language processing, drug discovery, and video recognition. Their vulnerability to input perturbation is also known. Aligning with a view…

Machine Learning · Computer Science 2021-05-14 Wei Huang , Youcheng Sun , Xingyu Zhao , James Sharp , Wenjie Ruan , Jie Meng , Xiaowei Huang

Gene regulation is a dynamic process that underlies all aspects of human development, disease response, and other key biological processes. The reconstruction of temporal gene regulatory networks has conventionally relied on regression…

Quantitative Methods · Quantitative Biology 2024-10-04 Euxhen Hasanaj , Barnabás Póczos , Ziv Bar-Joseph

In our earlier work, we introduced the concept of Gene Regulatory Neural Network (GRNN), which utilizes natural neural network-like structures inherent in biological cells to perform computing tasks using chemical inputs. We define this…

Neural and Evolutionary Computing · Computer Science 2024-03-14 Samitha Somathilaka , Adrian Ratwatte , Sasitharan Balasubramaniam , Mehmet Can Vuran , Witawas Srisa-an , Pietro Liò

Risk prediction capitalizing on emerging human genome findings holds great promise for new prediction and prevention strategies. While the large amounts of genetic data generated from high-throughput technologies offer us a unique…

Methodology · Statistics 2021-01-29 Xiaoxi Shen , Xiaoran Tong , Qing Lu

Circuits of biological neurons, such as in the functional parts of the brain can be modeled as networks of coupled oscillators. Inspired by the ability of these systems to express a rich set of outputs while keeping (gradients of) state…

Machine Learning · Computer Science 2021-03-16 T. Konstantin Rusch , Siddhartha Mishra

Recurrent Neural Networks (RNNs), which are a powerful scheme for modeling temporal and sequential data need to capture long-term dependencies on datasets and represent them in hidden layers with a powerful model to capture more information…

Machine Learning · Computer Science 2017-06-08 Andros Tjandra , Sakriani Sakti , Ruli Manurung , Mirna Adriani , Satoshi Nakamura

Environmental hazards place certain individuals at disproportionately higher risks. As these hazards increasingly endanger human health, precise identification of the most vulnerable population subgroups is critical for public health.…

Machine Learning · Computer Science 2024-09-23 Jong Woo Nam , Eun Young Choi , Jennifer A. Ailshire , Yao-Yi Chiang

For years, we have been building models of gene regulatory networks, where recent advances in molecular biology shed some light on new structural and dynamical properties of such highly complex systems. In this work, we propose a novel…

Adaptation and Self-Organizing Systems · Physics 2009-09-30 Christian Darabos , Marco Tomassini , Mario Giacobini

Modern neuroimaging techniques, such as diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), enable us to model the human brain as a brain network or connectome. Capturing brain networks' structural information…

In this work, we propose a novel recurrent neural network (RNN) architecture. The proposed RNN, gated-feedback RNN (GF-RNN), extends the existing approach of stacking multiple recurrent layers by allowing and controlling signals flowing…

Neural and Evolutionary Computing · Computer Science 2015-06-18 Junyoung Chung , Caglar Gulcehre , Kyunghyun Cho , Yoshua Bengio

Genes are fundamental for analyzing biological systems and many recent works proposed to utilize gene expression for various biological tasks by deep learning models. Despite their promising performance, it is hard for deep neural networks…

Machine Learning · Computer Science 2023-04-12 Xinnan Dai , Caihua Shan , Jie Zheng , Xiaoxiao Li , Dongsheng Li

Recurrent Neural Network (RNN) and its variations such as Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), have become standard building blocks for learning online data of sequential nature in many research areas, including…

Computation and Language · Computer Science 2020-05-12 Enmao Diao , Jie Ding , Vahid Tarokh

Reconstruction of gene regulatory networks is the process of identifying gene dependency from gene expression profile through some computation techniques. In our human body, though all cells pose similar genetic material but the activation…

In a previous paper, we have shown that a recurrent neural network (RNN) can be used to detect cellular network radio signal degradations accurately. We unexpectedly found, though, that accuracy gains diminished as we added layers to the…

Machine Learning · Computer Science 2024-04-18 David Mulvey , Chuan Heng Foh , Muhammad Ali Imran , Rahim Tafazolli

Recurrent neural networks (RNNs) are brain-inspired models widely used in machine learning for analyzing sequential data. The present work is a contribution towards a deeper understanding of how RNNs process input signals using the response…

Machine Learning · Statistics 2021-02-15 Soon Hoe Lim

Gene regulatory networks (GRNs) play a central role in cellular decision-making. Understanding their structure and how it impacts their dynamics constitutes thus a fundamental biological question. GRNs are frequently modeled as Boolean…

Molecular Networks · Quantitative Biology 2024-01-19 Claus Kadelka , Taras-Michael Butrie , Evan Hilton , Jack Kinseth , Addison Schmidt , Haris Serdarevic

Inferring gene regulatory networks (GRNs) from single-cell RNA sequencing (scRNA-seq) data is a complex challenge that requires capturing the intricate relationships between genes and their regulatory interactions. In this study, we tackle…

Machine Learning · Computer Science 2024-07-26 Sindhura Kommu , Yizhi Wang , Yue Wang , Xuan Wang

Transformers have surpassed RNNs in popularity due to their superior abilities in parallel training and long-term dependency modeling. Recently, there has been a renewed interest in using linear RNNs for efficient sequence modeling. These…

Computation and Language · Computer Science 2023-11-09 Zhen Qin , Songlin Yang , Yiran Zhong

Data-driven approaches to automated machine condition monitoring are gaining popularity due to advancements made in sensing technologies and computing algorithms. This paper proposes the use of a deep learning model, based on Long…

Signal Processing · Electrical Eng. & Systems 2019-07-30 Jianlei Zhang , Binil Starly

In this paper, we introduce a novel architecture to connecting adaptive learning and neural networks into an arbitrary machine's control system paradigm. Two consecutive Recurrent Neural Networks (RNNs) are used together to accurately model…

Machine Learning · Computer Science 2020-02-26 Srikanth Chandar , Harsha Sunder