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Advanced radiotherapy approaches such as FLASH irradiation and spatially fractionated radiotherapy (SFRT) show potential to improve the therapeutic ratio, yet their biological mechanisms and optimal delivery parameters remain uncertain.…

We present MInDI-3D (Medical Inversion by Direct Iteration in 3D), the first 3D conditional diffusion-based model for real-world sparse-view Cone Beam Computed Tomography (CBCT) artefact removal, aiming to reduce imaging radiation exposure.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-10 Daniel Barco , Marc Stadelmann , Martin Oswald , Ivo Herzig , Lukas Lichtensteiger , Pascal Paysan , Igor Peterlik , Michal Walczak , Bjoern Menze , Frank-Peter Schilling

Computed Tomography (CT) using synchrotron radiation is a powerful technique that, compared to lab-CT techniques, boosts high spatial and temporal resolution while also providing access to a range of contrast-formation mechanisms. The…

Image and Video Processing · Electrical Eng. & Systems 2025-01-20 Jiayang Shi , Daniel M. Pelt , K. Joost Batenburg

Cone-beam computed tomography (CBCT) typically requires hundreds of X-ray projections, which raises concerns about radiation exposure. While sparse-view reconstruction reduces the exposure by using fewer projections, it struggles to achieve…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Meng-Xun Li , Jin-Gang Yu , Yuan Gao , Cui Huang , Gui-Song Xia

Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose accumulation. Approach: We evaluated DIR accuracy in 25…

We present an integral-based technique (IBT) algorithm to accelerate supernova (SN) radiative transfer calculations. The algorithm utilizes ``integral packets'', which are calculated by the path integral of the Monte-Carlo energy packets,…

High Energy Astrophysical Phenomena · Physics 2024-09-13 Xingzhuo Chen , Lifan Wang , Daniel Kasen

Proton computed tomography (pCT) is a novel medical imaging modality for mapping the distribution of proton relative stopping power (RSP) in medical objects of interest. Compared to conventional X-ray computed tomography, where range…

Computational corrections of defocus and aberrations in optical coherence tomography (OCT) offers a promising approach to realize high-resolution imaging with deep imaging depth, but without additional high hardware costs. However, these…

Optics · Physics 2025-10-28 Shuichi Makita , Naoki Fukutake , Lida Zhu , Yoshiaki Yasuno

Intraoperative Cone Beam Computed Tomography (CBCT) provides a reliable 3D anatomical context essential for interventional planning. However, its static nature fails to provide continuous monitoring of soft-tissue deformations induced by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Feng Li , Ziyuan Li , Zhongliang Jiang , Nassir Navab , Yuan Bi

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Introduction: This study uses KV CBCT based Synthetic CT (sCT) generated through Velocity workstation and compare the target and normal tissue doses with Adaptive plan CT doses. Methods: Thirty head and neck cancer patients undergoing…

This study aims to develop a digital twin (DT) framework to enhance adaptive proton stereotactic body radiation therapy (SBRT) for prostate cancer. Prostate SBRT has emerged as a leading option for external beam radiotherapy due to its…

Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…

Image and Video Processing · Electrical Eng. & Systems 2023-10-12 Wenjun Xia , Yongyi Shi , Chuang Niu , Wenxiang Cong , Ge Wang

Purpose: To verify dose delivery and quality assurance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Method: The Imaging and Radiation Oncology Core Houston (IROC-H) head and neck phantom with thermo- luminescent…

Beam angle optimization (BAO) largely determines the performance of fixed-field intensity modulated radiation therapy (IMRT), and it is usually considered as non-convex optimization and an NP hard problem. In this work, BAO is reformulated…

Medical Physics · Physics 2021-05-12 Junbo Peng , Ailin Wu , Lei Zhu

This paper introduces a novel method for reconstructing cone beam computed tomography (CBCT) images for arbitrary orbits using a differentiable shift-variant filtered backprojection (FBP) neural network. Traditional CBCT reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Chengze Ye , Linda-Sophie Schneider , Yipeng Sun , Mareike Thies , Siyuan Mei , Andreas Maier

Neutron computed tomography (nCT) is a 3D characterization technique used to image the internal morphology or chemical composition of samples in biology and materials sciences. A typical workflow involves placing the sample in the path of a…

Computed Tomography (CT) measures the attenuation coefficient of an object and converts the value assigned to each voxel into a CT number. In radiation therapy, CT number, which is directly proportional to the linear attenuation…

Medical Physics · Physics 2015-03-13 Dong Joo Rhee , Sung-woo Kim , Young Min Moon , Jung Ki Kim , Dong Hyeok Jeong

Various multi-modal imaging sensors are currently involved at different steps of an interventional therapeutic work-flow. Cone beam computed tomography (CBCT), computed tomography (CT) or Magnetic Resonance (MR) images thereby provides…

Image and Video Processing · Electrical Eng. & Systems 2020-11-25 Luc Lafitte , Rémi Giraud , Cornel Zachiu , Mario Ries , Olivier Sutter , Antoine Petit , Olivier Seror , Clair Poignard , Baudouin Denis de Senneville

Purpose: In this study, we present the creation of an anthropomorphic, head and neck, nuclear medicine phantom and its characterization for the validation of a Monte Carlo, SPECT image based, Iodine-131 RPT dosimetry workflow. Methods: 3D…