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Adaptive Radiotherapy (ART) is an emerging technique for treating cancer patients which facilitates higher delivery accuracy and has the potential to reduce toxicity. However, ART is also resource-intensive, requiring extra human and…
Particle therapy is an established method to treat deep-seated tumours using accelerator-produced ion beams. For treatment planning, the precise knowledge of the relative stopping power (RSP) within the patient is vital. Conversion errors…
The application of ionizing radiation for diagnostic imaging is common around the globe. However, the process of imaging, itself, remains to be a relatively hazardous operation. Therefore, it is preferable to use as low a dose of ionizing…
Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…
Contouring of the target volume and Organs-At-Risk (OARs) is a crucial step in radiotherapy treatment planning. In an adaptive radiotherapy setting, updated contours need to be generated based on daily imaging. In this work, we leverage…
Adaptive radiotherapy (ART), especially online ART, effectively accounts for positioning errors and anatomical changes. One key component of online ART is accurately and efficiently delineating organs at risk (OARs) and targets on online…
Cone-beam tomography enables rapid 3D acquisitions, making it a suitable imaging modality for dental imaging. However, as with all X-ray techniques, the main challenge is to reduce the dose while maintaining good image quality. Moreover,…
Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton therapy (IMPT). However, the efficient treatment delivery of…
Cone beam computed tomography (CBCT) is an emerging medical imaging technique to visualize the internal anatomical structures of patients. During a CBCT scan, several projection images of different angles or views are collectively utilized…
Pencil x-ray beam imaging provides superior spatial resolution than other imaging geometries like sheet beam and cone beam geometries due to the illumination of a line instead of an area or volume. However, the pencil beam geometry suffers…
Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung,…
Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…
Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…
Radiation transport simulations were used to analyse neutron imaging with the current-biased kinetic inductance detector (CB-KID). The PHITS Monte Carlo code was applied for simulating neutron, $^{4}$He, $^{7}$Li, photon and electron…
Purpose: The presence of respiratory motion during radiation treatment leads to degradation of the expected dose distribution, both for target coverage and healthy-tissue sparing, particularly for techniques like pencil-beam scanning proton…
Early identification of head and neck cancer (HNC) patients who would experience significant anatomical change during radiotherapy (RT) is important to optimize patient clinical benefit and treatment resources. This study aims to assess the…
Purpose: Deformable image registration (DIR) is critical in adaptive radiation therapy (ART) to account for anatomical changes. Conventional intensity-based DIR methods often fail when image intensities differ. This study evaluates a hybrid…
In adaptive radiotherapy, deformable image registration is often conducted between the planning CT and treatment CT (or cone beam CT) to generate a deformation vector field (DVF) for dose accumulation and contour propagation. The auto…
To shorten the door-to-puncture time for better treating patients with acute ischemic stroke, it is highly desired to obtain quantitative cerebral perfusion images using C-arm cone-beam computed tomography (CBCT) equipped in the…
Purpose: To characterize image quality, imaging dose, and dose calculation accuracy for an upright CT scanner with a six-degree-of-freedom patient positioning system. Methods: Imaging dose (CTDIvol) was measured at 120 kVp and 200 mAs.…