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How cells with diverse morphologies and cytoskeletal architectures modulate their mechanical behaviors to drive robust collective motion within tissues is poorly understood. During wound repair within epithelial monolayers in vitro, cells…

The transport and chemical reactions of solutes are modelled as a cellular automaton in which molecules of different species perform a random walk on a regular lattice and react according to a local probabilistic rule. The model describes…

comp-gas · Physics 2009-10-22 T. Karapiperis , B. Blankleider

The articulation process of dynamical networks is studied with a functional map, a minimal model for the dynamic change of relationships through iteration. The model is a dynamical system of a function $f$, not of variables, having a…

adap-org · Physics 2009-10-31 N. Kataoka , K. Kaneko

During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can…

Cell Behavior · Quantitative Biology 2020-06-24 Carsten Beta , Nir S. Gov , Arik Yochelis

Understanding the structures of biological macromolecules is highly important as they are closely associated with cellular functionalities. Comprehending the precise organization actin filaments is crucial because they form the dynamic…

Image and Video Processing · Electrical Eng. & Systems 2024-03-27 Salim Sazzed

In this paper, we develop and analyze a minimal model for a 2D network of cross-linked actin filaments and myosin motors, representing the cortical cytoskeleton of eukaryotic cells. We implement coarse-grained representations of force…

Subcellular Processes · Quantitative Biology 2016-12-23 William M. McFadden , Patrick M. McCall , Edwin M. Munro

The cell cortex is a thin layer beneath the plasma membrane that gives animal cells mechanical resistance and drives most of their shape changes, from migration, division to multicellular morphogenesis. It is mainly composed of actin…

Biological Physics · Physics 2022-05-04 Hudson Borja da Rocha , Jérémy Bleyer , Hervé Turlier

Cell crawling requires the generation of intracellular forces by the cytoskeleton and their transmission to an extracellular substrate through specific adhesion molecules. Crawling cells show many features of excitable systems, such as…

Biological Physics · Physics 2020-06-02 Pierre Sens

We consider hexagonal cellular automata with immediate cell neighbourhood and three cell-states. Every cell calculates its next state depending on the integral representation of states in its neighbourhood, i.e. how many neighbours are in…

Artificial Intelligence · Computer Science 2010-11-23 Andrew Adamatzky , Larry Bull , Pierre Collet , Emmanuel Sapin

The emergence of complex behaviors in cellular automata is an area that has been widely developed in recent years with the intention to generate and analyze automata that produce space-moving patterns or gliders that interact in a periodic…

A motile cell, when stimulated, shows a dramatic increase in the activity of its membrane, manifested by the appearance of dynamic membrane structures such as lamellipodia, filopodia and membrane ruffles. The external stimulus turns on…

Soft Condensed Matter · Physics 2009-11-11 Nir Gov , Ajay Gopinathan

Cell motility and tissue morphogenesis depend crucially on the dynamic remodelling of actomyosin networks. An actomyosin network consists of an actin polymer network connected by crosslinker proteins and motor protein myosins that generate…

Soft Condensed Matter · Physics 2016-05-25 Chiu Fan Lee , Gunnar Pruessner

A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide…

Biomolecules · Quantitative Biology 2007-08-18 Ping Xie , Shuo-Xing Dou , Peng-Ye Wang

Branched actin networks at the leading edge of a crawling cell evolve via protein-regulated processes such as polymerization, depolymerization, capping, branching, and severing. A formulation of these processes is presented and analyzed to…

Soft Condensed Matter · Physics 2009-11-13 Ajay Gopinathan , Kun-Chun Lee , J. M. Schwarz , Andrea J. Liu

Cellular actin structures are continuously turned over while keeping similar sizes. Since they all compete for a shared pool of actin monomers, the question arises how they can coexist in these dynamic steady states. Recently, the…

Subcellular Processes · Quantitative Biology 2026-04-27 Valentin Wössner , Falko Ziebert , Ulrich S. Schwarz

The composite cytoskeleton, comprising interacting networks of semiflexible actin and rigid microtubules, actively generates forces and restructures using motor proteins such as myosins to enable key mechanical processes including cell…

We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions. The motor proteins consist of polymeric tails tethered to the plane and modeled as…

Statistical Mechanics · Physics 2015-03-19 Shiladitya Banerjee , M. Cristina Marchetti , Kristian Müller-Nedebock

Cells in a fungal hyphae are separated by internal walls (septa). The septa have tiny pores that allow cytoplasm flowing between cells. Cells can close their septa blocking the flow if they are injured, preventing fluid loss from the rest…

Cellular Automata and Lattice Gases · Physics 2023-07-13 Carlos S. Sepúlveda , Eric Goles , Martín Ríos-Wilson , Andrew Adamatzky

Gravitational clustering of a random distribution of point masses is dominated by the effective short-range interactions due to large-scale isotropy. We introduce a one-dimensional cellular automaton to reproduce this effect in the most…

Condensed Matter · Physics 2009-11-07 Roya Mohayaee , Luciano Pietronero

We propose and analyse an active hydrodynamic theory that characterises the effects of the scaffold protein anillin. Anillin is found at major sites of cortical activity, such as adherens junctions and the cytokinetic furrow, where the…

Subcellular Processes · Quantitative Biology 2024-02-13 Denni Currin-Ross , Sami C. Al-Izzi , Ivar Noordstra , Alpha S. Yap , Richard G. Morris
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