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In real-world practice, medical images acquired in different phases possess complementary information, {\em e.g.}, radiologists often refer to both arterial and venous scans in order to make the diagnosis. However, in medical image…

Computer Vision and Pattern Recognition · Computer Science 2019-09-13 Huangjie Zheng , Lingxi Xie , Tianwei Ni , Ya Zhang , Yan-Feng Wang , Qi Tian , Elliot K. Fishman , Alan L. Yuille

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi

High-speed optical imaging of dynamic neuronal activity is essential yet challenging in neuroscience. While calcium imaging has been firmly established as a workhorse technique for monitoring neuronal activity, its limited temporal…

We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown {\it in vitro}. We infer connectivity between two…

Neurons and Cognition · Quantitative Biology 2007-05-23 Luis M. A. Bettencourt , Greg J. Stephens , Michael I. Ham , Guenter W. Gross

This paper considers the problem of brain disease classification based on connectome data. A connectome is a network representation of a human brain. The typical connectome classification problem is very challenging because of the small…

Machine Learning · Statistics 2020-01-24 Nikita Mokrov , Maxim Panov , Boris A. Gutman , Joshua I. Faskowitz , Neda Jahanshad , Paul M. Thompson

Background: Current neuronal monitoring techniques, such as calcium imaging and multi-electrode arrays, enable recordings of spiking activity from hundreds of neurons simultaneously. Of primary importance in systems neuroscience is the…

Neurons and Cognition · Quantitative Biology 2014-11-11 Yazan N. Billeh , Michael T. Schaub , Costas A. Anastassiou , Mauricio Barahona , Christof Koch

Coronary artery calcium (CAC) is biomarker of advanced subclinical coronary artery disease and predicts myocardial infarction and death prior to age 60 years. The slice-wise manual delineation has been regarded as the gold standard of…

Computer Vision and Pattern Recognition · Computer Science 2018-11-13 Yuankai Huo , James G. Terry , Jiachen Wang , Vishwesh Nath , Camilo Bermudez , Shunxing Bao , Prasanna Parvathaneni , J. Jeffery Carr , Bennett A. Landman

Calcium imaging is an essential tool to study the activity of neuronal populations. However, the high level of background fluorescence in images hinders the accurate identification of neurons and the extraction of neuronal activities. While…

Image and Video Processing · Electrical Eng. & Systems 2021-08-05 Seungjae Han , Eun-Seo Cho , Inkyu Park , Kijung Shin , Young-Gyu Yoon

Researchers continue exploring neurons' intricate patterns of activity in the cerebral visual cortex in response to visual stimuli. The way neurons communicate and optimize their interactions with each other under different experimental…

Neurons and Cognition · Quantitative Biology 2024-02-09 Lauren Miako Beede , Giuseppe Vinci

In this study we adopt predictive modelling to identify simultaneously commonalities and differences in multi-modal brain networks acquired within subjects. Typically, predictive modelling of functional connectomes from structural…

Neurons and Cognition · Quantitative Biology 2019-11-06 Fani Deligianni , Jonathan D. Clayden , Guang-Zhong Yang

Non-invasive measurements of the human brain using magnetic resonance imaging (MRI) have significantly improved our understanding the brain's network organization by enabling measurement of anatomical connections between brain regions…

Applications · Statistics 2025-12-10 Keshav Motwani , Ali Shojaie , Ariel Rokem , Eardi Lila

The connectome is a wiring diagram mapping all the neural connections in the brain. At the cellular level, it provides a map of the neurons and synapses within a part or all of the brain of an organism. In recent years, significant advances…

Neurons and Cognition · Quantitative Biology 2022-06-01 Adrián Hernández , José M. Amigó

Recent studies proposed the use of Total Correlation to describe functional connectivity among brain regions as a multivariate alternative to conventional pair-wise measures such as correlation or mutual information. In this work we build…

Neurons and Cognition · Quantitative Biology 2022-11-28 Qiang Li , Greg Ver Steeg , Shujian Yu , Jesus Malo

Identification of different neuronal cell types is critical for understanding their contribution to brain functions. Yet, automated and reliable classification of neurons remains a challenge, primarily because of their biological…

Neural and Evolutionary Computing · Computer Science 2020-09-29 Eirini Troullinou , Grigorios Tsagkatakis , Spyridon Chavlis , Gergely Turi , Wen-Ke Li , Attila Losonczy , Panagiotis Tsakalides , Panayiota Poirazi

Inferring network topology from smooth signals is a significant problem in data science and engineering. A common challenge in real-world scenarios is the availability of only partially observed nodes. While some studies have considered…

Machine Learning · Computer Science 2025-07-08 Chuansen Peng , Hanning Tang , Zhiguo Wang , Xiaojing Shen

There has been an explosion of interest in functional Magnetic Resonance Imaging (MRI) during the past two decades. Naturally, this has been accompanied by many major advances in the understanding of the human connectome. These advances…

Machine Learning · Statistics 2016-10-31 Ricardo Pio Monti , Romy Lorenz , Christoforos Anagnostopoulos , Robert Leech , Giovanni Montana

Calcium imaging allows for the parallel measurement of large neuronal populations in a spatially resolved and minimally invasive manner, and has become a gold-standard for neuronal functionality. While deep generative models have been…

Neurons and Cognition · Quantitative Biology 2025-10-02 Berta Ros , Mireia Olives-Verger , Caterina Fuses , Josep M Canals , Jordi Soriano , Jordi Abante

Closed-loop neuroscience experimentation, where recorded neural activity is used to modify the experiment on-the-fly, is critical for deducing causal connections and optimizing experimental time. A critical step in creating a closed-loop…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Iuliia Dmitrieva , Sergey Babkin , Adam S. Charles

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Calcium imaging is a critical tool for measuring the activity of large neural populations. Much effort has been devoted to developing "pre-processing" tools for calcium video data, addressing the important issues of e.g., motion correction,…

Neurons and Cognition · Quantitative Biology 2020-06-09 Xue-Xin Wei , Ding Zhou , Andres Grosmark , Zaki Ajabi , Fraser Sparks , Pengcheng Zhou , Mark Brandon , Attila Losonczy , Liam Paninski
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