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A molecule traveling in a realistic propagation environment can experience stochastic interactions with other molecules and the environment boundary. The statistical behavior of some isolated phenomena, such as dilute unbounded molecular…

Chemical Physics · Physics 2015-05-20 Adam Noel , Karen C. Cheung , Robert Schober

Multiplicity fluctuations of intermediate-mass fragments are studied with the percolation model. It is shown that super-Poissonian fluctuations occur near the percolation transition and that this behavior is associated with the…

Nuclear Theory · Physics 2009-10-31 Tarek Gharib , Wolfgang Bauer , Scott Pratt

Biomolecular condensates are small droplets forming spontaneously in biological cells via phase separation. They play a role in many cellular processes, but it is unclear how cells control them. Cellular regulation often relies on…

Soft Condensed Matter · Physics 2024-03-15 Jan Kirschbaum , David Zwicker

Condensation of fluctuations is an interesting phenomenon conceptually distinct from condensation on average. One stricking feature is that, contrary to what happens on average, condensation of fluctuations may occurr even in the absence of…

Statistical Mechanics · Physics 2014-07-31 Marco Zannetti , Federico Corberi , Giuseppe Gonnella

We show how one can measure the signal from slow jumps of a single molecule between metastable positions using a setup where the molecule is fixed to one lead, and one of the coupling strengths is controlled externally. Such a measurement…

Mesoscale and Nanoscale Physics · Physics 2013-04-04 Tero T. Heikkila , Wolfgang Belzig

Molecular dynamics simulations have revealed a dramatic increase, with increasing temperature, of the amplitude of electrostatic fluctuations caused by water at the active site of metalloprotein plastocyanin. The increased breadth of…

Biological Physics · Physics 2009-11-13 David N. LeBard , Dmitry V. Matyushov

We investigate a model protein interaction network whose links represent interactions between individual proteins. This network evolves by the functional duplication of proteins, supplemented by random link addition to account for…

Statistical Mechanics · Physics 2009-11-07 J. Kim , P. L. Krapivsky , B. Kahng , S. Redner

In thermodynamic equilibrium, the fluctuation-dissipation theorem links thermal fluctuations and dissipation. Biological systems, however, are driven out of equilibrium by internal processes that produce additional, active fluctuations.…

Soft Condensed Matter · Physics 2026-01-29 Ashot Matevosyan , Frank Jülicher , Ricard Alert

Living organisms are non-equilibrium, fluctuating, dynamic systems containing multi-step biological signaling cascades (BSC) with the ability to transduce changes in the concentration of extracellular molecules such as cytokines into…

Molecular Networks · Quantitative Biology 2015-12-09 Tatsuaki Tsuruyama

We give rigorous analytical results on the temporal behavior of two-point correlation functions --also known as dynamical response functions or Green's functions-- in closed many-body quantum systems. We show that in a large class of…

Quantum Physics · Physics 2020-03-20 Álvaro M. Alhambra , Jonathon Riddell , Luis Pedro García-Pintos

Understanding the relationship between spontaneous stochastic fluctuations and the topology of the underlying gene regulatory network is of fundamental importance for the study of single-cell stochastic gene expression. Here by solving the…

Molecular Networks · Quantitative Biology 2017-10-25 Chen Jia , Peng Xie , Min Chen , Michael Q. Zhang

Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be…

Subcellular Processes · Quantitative Biology 2017-04-12 Gabriele Micali , Gerardo Aquino , David M. Richards , Robert G. Endres

In many chemical reactions, reaction rate fluctuation is inevitable. Reaction rates are different whenever chemical reaction occurs due to their dependence on the number of reaction events or the product number. As such, understanding the…

Molecular Networks · Quantitative Biology 2024-06-19 Seong Jun Park

In order to compare theoretical calculations of thermal fluctuations of conserved quantities, such as charge susceptibilities or the specific heat, to experimentally measured correlations and fluctuations in heavy ion collisions, one must…

Nuclear Theory · Physics 2017-05-31 Scott Pratt , Clint Young

Cells sense environmental signals and transmit information intracellularly through changes in the abundance of molecular components. Such molecular abundances can be measured in single cells and exhibit significant heterogeneity in clonal…

Quantitative Methods · Quantitative Biology 2024-09-27 Raymond Fan , Andreas Hilfinger

"\textit{The noise is the signal}"[R. Landauer, Nature \textbf{392}, 658 (1998)] emphasizes the rich information content encoded in fluctuations. This paper assesses the dynamical role of fluctuations of a quantum system driven far from…

Quantum Physics · Physics 2015-03-10 Yi-Jen Chen , Stefan Pabst , Zheng Li , Oriol Vendrell , Robin Santra

We measure the fluctuations of the position of a Brownian particle confined by an optical trap in an aging gelatin droplet after a fast quench. Its linear response to an external perturbation is also measured. We compute the spontaneous…

Statistical Mechanics · Physics 2012-03-05 Juan Ruben Gomez-Solano , Artyom Petrosyan , Sergio Ciliberto

Active matter systems under confinement display persistent surface motion and a strong boundary affinity. However, despite extensive studies of their positional dynamics, much less attention has been given to the corresponding orientational…

Soft Condensed Matter · Physics 2026-05-21 Elsa Baby , Manoj Gopalakrishnan , Vishwas V. Vasisht

Many chemical reactions in biological cells occur at very low concentrations of constituent molecules. Thus, transcriptional gene-regulation is often controlled by poorly expressed transcription-factors, such as E.coli lac repressor with…

Quantitative Methods · Quantitative Biology 2016-09-27 O. Pulkkinen , R. Metzler

Many molecular junctions display stochastic telegraphic switching between two distinct current values, which is therefore an important source of fluctuations in nanoscale quantum transport. We investigate electronic fluctuations arising via…

Mesoscale and Nanoscale Physics · Physics 2019-12-25 Samuel L. Rudge , Daniel S. Kosov