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This study investigates the dynamics of non-spatial specializations in hippocampal place cells during exposure to novel environments. Hippocampal place cells, known for their role in spatial mapping, exhibit multi-modal responses to sensory…

Animal behavior and neural recordings show that the brain is able to measure both the intensity of an odor and the timing of odor encounters. However, whether intensity or timing of odor detections is more informative for olfactory-driven…

Quantitative Methods · Quantitative Biology 2021-06-17 Nicola Rigolli , Nicodemo Magnoli , Lorenzo Rosasco , Agnese Seminara

We present a neural algorithm for the rapid online learning and identification of odorant samples under noise, based on the architecture of the mammalian olfactory bulb and implemented on the Intel Loihi neuromorphic system. As with…

Neural and Evolutionary Computing · Computer Science 2020-05-26 Nabil Imam , Thomas A. Cleland

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

Chemical Physics · Physics 2026-05-18 Peter Fichtelmann , Julia Westermayr

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

Neurons and Cognition · Quantitative Biology 2023-10-13 Jack A. Cook , Thomas A. Cleland

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. The current artificial sensors developed for odor detection struggle with complex mixtures while non-invasive recordings lack…

Machine Learning · Computer Science 2025-08-14 Matin Hassanloo , Ali Zareh , Mehmet Kemal Özdemir

Living systems continually respond to signals from the surrounding environment. Survival requires that their responses adapt quickly and robustly to the changes in the environment. One particularly challenging example is olfactory…

Neurons and Cognition · Quantitative Biology 2024-10-08 Kiri Choi , Will Rosenbluth , Isabella R. Graf , Nirag Kadakia , Thierry Emonet

We explore a suite of generative modelling techniques to efficiently navigate and explore the complex landscapes of odor and the broader chemical space. Unlike traditional approaches, we not only generate molecules but also predict the odor…

Machine Learning · Computer Science 2025-02-03 Mrityunjay Sharma , Sarabeshwar Balaji , Pinaki Saha , Ritesh Kumar

The olfactory system is constantly solving pattern-recognition problems by the creation of a large space to codify odour representations and optimizing their distribution within it. A model of the Olfactory Bulb was developed by Z. Li and…

Adaptation and Self-Organizing Systems · Physics 2019-05-16 Alexandra Pinto

The olfactory system of male moths is exquisitely sensitive to pheromones emitted by females and transported in the environment by atmospheric turbulence. Moths respond to minute amounts of pheromones and their behavior is sensitive to the…

Quantitative Methods · Quantitative Biology 2014-11-14 Antonio Celani , Emmanuel Villermaux , Massimo Vergassola

A mechanism is proposed for increasing selectivity of olfactory bulb projection neurons as compared to the olfactory receptor neurons, which could operate under low odor concentration, when the lateral inhibition mechanism becomes…

Neurons and Cognition · Quantitative Biology 2021-11-09 Alexander Vidybida

Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional…

Neurons and Cognition · Quantitative Biology 2012-12-27 Anneke Meyer , Giovanni Galizia , Martin P. Nawrot

We present a model for olfactory coding based on spatial representation of glomerular responses. In this model distinct odorants activate specific subsets of glomeruli, dependent upon the odorant's chemical identity and concentration. The…

Neurons and Cognition · Quantitative Biology 2007-05-23 A. Koulakov , A. Gelperin , D. Rinberg

Olfactory search in turbulent environments is a sensorimotor challenge solved with remarkable efficiency by many animals, yet replicating this ability in artificial systems remains difficult because detections are intermittent and wind…

Olfactory perception plays a critical role in both human and organismal interactions, yet understanding of its underlying mechanisms and influencing factors remain insufficient. Molecular structures influence odor perception through…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Jian Wang

Early olfactory pathway responses to the presentation of an odor exhibit remarkably similar dynamical behavior across phyla from insects to mammals, and frequently involve transitions among quiescence, collective network oscillations, and…

Neurons and Cognition · Quantitative Biology 2020-09-29 Pamela B Pyzza , Katherine A Newhall , Douglas Zhou , Gregor Kovacic , David Cai

Odor source localization is a fundamental challenge in molecular communication, environmental monitoring, disaster response, industrial safety, and robotics. In this study, we investigate three major approaches: Bayesian filtering, machine…

Signal Processing · Electrical Eng. & Systems 2025-02-12 Ayse Sila Okcu , Ozgur B. Akan

In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We propose a novel strategy for encoding intensity-invariant stimuli identity that is based on…

Neurons and Cognition · Quantitative Biology 2016-09-09 Daniel Kepple , Hamza Giaffar , Dmitry Rinberg , Alexei Koulakov

It has been discovered before (arXiv:2306.07676) that for the selectivity gain due to fluctuations in the process of primary odor reception by olfactory receptor neuron (ORN) there exists an optimal concentration of odors at which increased…

Neurons and Cognition · Quantitative Biology 2025-04-15 A. K. Vidybida

Insects identify and evaluate behaviorally relevant odorants in complex natural scenes where odor concentrations and mixture composition can change rapidly. In the honeybee, a combinatorial code of activated and inactivated projection…

Biological Physics · Physics 2011-01-06 Martin Paul Nawrot , Sabine Krofczik , Farzad Farkhooi , Randolf Menzel