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Related papers: On a diffuse interface model of tumor growth

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We consider a diffuse interface model describing a ternary system constituted by a conductive diblock copolymer and a homopolymer acting as solvent. The resulting dynamics is modeled by two Cahn--Hilliard--Oono equations for the copolymer…

Analysis of PDEs · Mathematics 2024-11-07 Helmut Abels , Andrea Di Primio , Harald Garcke

A phase field model for tumour growth is introduced that is based on a Brinkman law for convective velocity fields. The model couples a convective Cahn-Hilliard equation for the evolution of the tumour to a reaction-diffusion-advection…

Analysis of PDEs · Mathematics 2021-09-07 Matthias Ebenbeck , Harald Garcke , Robert Nürnberg

Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…

Analysis of PDEs · Mathematics 2015-06-12 Benoît Perthame , Fernando Quirós , Juan Luis Vázquez

The comprehension of tumor growth is a intriguing subject for scientists. New researches has been constantly required to better understand the complexity of this phenomenon. In this paper, we pursue a physical description that account for…

Biological Physics · Physics 2017-05-16 Fabiano L. Ribeiro , Renato Vieira dos Santos , Angélica S. Mata

We consider a Hele-Shaw model that describes tumor growth subject to nutrient supply. The model is derived by taking the incompressible limit of porous medium type equations, and the boundary instability of this model was recently studied…

Analysis of PDEs · Mathematics 2025-05-13 Yu Feng , Qingyou He , Jian-Guo Liu , Zhennan Zhou

In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

This paper develops an abstract theory for subdifferential operators to give existence and uniqueness of solutions to the initial-boundary problem (P) for the nonlinear diffusion equation in an unbounded domain $\Omega\subset\mathbb{R}^N$…

Analysis of PDEs · Mathematics 2018-05-09 Takeshi Fukao , Shunsuke Kurima , Tomomi Yokota

We investigate the Cahn-Hilliard equation with nonlinear diffusion and non-degenerate mobility modeling phase separation phenomena in complex systems (e.g., crystals and polymers). Previous results in the literature on this model relied on…

Analysis of PDEs · Mathematics 2025-10-10 Monica Conti , Stefania Gatti , Andrea Giorgini , Giulio Schimperna

In this letter, we derive the sharp-interface limit of the Cahn-Hilliard-Biot equations using formal matched asymptotic expansions. We find that in each sub-domain, the quasi-static Biot equations are obtained with domain-specific material…

Analysis of PDEs · Mathematics 2024-12-06 Erlend Storvik , Carina Bringedal

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

We present a phase-space analysis of a mathematical model of tumor growth with an immune responses. We consider mathematical analysis of the model equations with multipoint initial condition regarding to dissipativity, boundedness of…

Dynamical Systems · Mathematics 2019-02-28 Veli Shakhmurov , Rishad Shahmurov

The purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen-Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models, and prove convergence…

Analysis of PDEs · Mathematics 2022-12-23 Tim Laux , Kerrek Stinson , Clemens Ullrich

In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which…

Analysis of PDEs · Mathematics 2021-06-23 Marvin Fritz , Prashant K. Jha , Tobias Köppl , J. Tinsley Oden , Barbara Wohlmuth

In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…

Biological Physics · Physics 2023-02-07 Maxim V. Polyakov , Valeria V. Ten

Dynamic wetting poses a well-known challenge in classical sharp-interface formulation as the no-slip wall condition leads to a contact line singularity that is typically regularized with a Navier boundary condition, often requiring…

Fluid Dynamics · Physics 2025-11-13 Tomas Fullana , Stéphane Zaleski , Gustav Amberg

We consider a diffuse interface model for phase separation of an isothermal incompressible binary fluid in a Brinkman porous medium. The coupled system consists of a convective Cahn-Hilliard equation for the phase field $\phi$, i.e., the…

Analysis of PDEs · Mathematics 2014-08-15 Stefano Bosia , Monica Conti , Maurizio Grasselli

The diffuse interface model of Cahn-Hilliard-van der Waals is often used to study various aspects of multi-phase flows such as droplets coalescence and contact line dynamics. The original model of Cahn-Hilliard-van der Waals uses an…

Fluid Dynamics · Physics 2014-08-29 Lionel Hirschberg , Avraham Hirschberg

We propose a new Cahn-Hilliard phase field model coupled to incompressible viscoelasticity at large strains, obtained from a diffuse interface mixture model and formulated in the Eulerian configuration. A new kind of diffusive…

Analysis of PDEs · Mathematics 2023-01-23 Abramo Agosti , Pierluigi Colli , Harald Garcke , Elisabetta Rocca

A well-known diffuse interface model for incompressible isothermal mixtures of two immiscible fluids consists of the Navier-Stokes system coupled with a convective Cahn-Hilliard equation. In some recent contributions the standard…

Analysis of PDEs · Mathematics 2013-01-14 Sergio Frigeri , Maurizio Grasselli , Pavel Krejčí

In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate…

Analysis of PDEs · Mathematics 2021-06-22 Jian-Guo Liu , Xiangsheng Xu